Liam Carroll

Name: Liam Carroll

Level at MPU: MSc.

Email: liam.carroll [at] mail.mcgill.ca

Supervisor(s): Dr. Shirin Enger

Research interests: Dynamic PET, Device Development, nuclear medicine

 

Research summary


Positron Emission Tomography (PET) is a nuclear medicine imaging technique that tracks the location of radio-labelled molecules through the human body. This technique has a wide range of applications from disease detection to pharmacokinetic analysis of new drugs. PET data can be viewed statically (s single integrated image) or dynamically (following the time-activity curve of the tissue of interested). Dynamic scans are more interesting due to the additional kinetic information they provide but require an additional input in the form of the time activity curve in the patient's arteries called the arterial input function (AIF). The AIF is traditionally acquired using invasive arterial blood sampling, an invasive and expensive procedure, which limits dynamic PET to academic PET centers. This project aims to develop and optimize a non-invasive positron detector to measure the arterial input function (AIF) in dynamic positron emission tomography (PET) imaging. This would allow dynamic PET scans to be acquired in any clinic where static PET is normally performed. We are using fast plastic scintillators coupled to optical fiber and SiPMTs to detect positrons leaving the radial/ulnar arteries. This project is currently in a prototype phase.
 

 

Key publications

  1. Carroll L, Croteau E, Kertzscher G, Sarrhini O, Turgeon V, Lecomte R, Enger SA. Cross-validation of a non-invasive positron detector to measure the arterial input function for pharmacokinetic modelling in dynamic positron emission tomography. Physica Medica. 75:92-99. 2020 (link).
  2. Turgeon V, Kertzscher G, Carroll L, Hopewell R, Massarweh G, Enger SA. Characterization of scintillating fibers for use as positron detector in positron emission tomography. Physica Medica. 65:114-120. 2019 (link).

 

Awards

CSACS summer student program (2014)

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