Name: Judy Wang, MSc
Level at MPU: PhD
Email: xiaoya.wang [at] mail.mcgill.ca
Supervisor(s): Dr. Jan Seuntjens
Research interests: Microdosimetry, Nanodosimetry
In the study of dosimetry, Monte Carlo (MC) simulations of absorbed dose are correlated with biological endpoints to establish a relationship between physically measured quantities and biological damage. The simulations generally assume a uniform material such as water, and the simulated region is divided into 'voxels' many orders of magnitude larger than a cell for scoring purposes. Such an approach cannot lead to an understanding of biological damage from a fundamental, bottom-up point of view.
In recent years, as the need for a microscopic theory of radiation damage became increasingly important, the focus has shifted onto studying the physical and chemical processes of DNA damage by ionizing radiation. To do so, track structure MC codes recording every interaction a particle undergoes have been developed and extended to lower energies, where particle ranges are comparable to the size of DNA. However, most track structure codes only model interactions in water, and a complete set of cross sections for DNA does not yet exist.
As a first goal, we propose to modify ELSEPA, a package for the calculation of elastic scattering cross sections of electrons by atoms and ions, to be suitable for large molecules such as DNA. We also plan to perform inelastic cross section calculations, before implementing our scattering processes in the open source code Geant4-DNA. These new physical processes will contribute to a more complete understanding of biological damage at microscopic levels.
FRQNT doctoral research scholarship (Jan 2014 - Dec 2016)
Chalk Rowles fellowship (2012 - 2013)