Felix Mathew

Name: Felix Mathew

Most recent degree: MSc. Medical Radiation Physics - McGill

Level at MPU: PhD

Email: felix.mathew [at] mail.mcgill.ca

Supervisor(s): Dr. John Kildea

Research interests:  Neutron Induced Carcinogenic Effects

Research summary

A recent study by Behjati et al. (2016), demonstrated that radiotherapy-associated tumours have mutational signatures in their genomes that are distinct from radiation-naive tumours. These results were limited to low-LET radiation and cannot be easily reproduced in a lab setting. We hypothesize that the mutational signatures of ionizing radiation can be determined from human cells exposed to radiation in vitro using single-cell whole-genome sequencing. Since high-LET radiation is more citoxic and capable of inducing clustured and complex DNA damages that are difficult for the cells to repair, we expect high-LET has a mutational signature different from low-LET. So the objective of this thesis research is to characterize the high-LET genomic mutational signature from neutron (high-LET) irradiated cells through single-cell sequencing techniques.

Key publications

Mathew, F., Al Makdessi, G., Montgomery, L., Evans, M., & Kildea, J. (2020). The impact of treatment parameter variation on secondary neutron spectra in high-energy electron beam radiotherapy. Physica Medica, 80, 125-133

Mathew, F., Chilian, C., Montgomery, L., & Kildea, J. (2020). Development of a passive gold-foil Nested Neutron Spectrometer to validate the active current-mode He-3 measurements in a high neutron fluence rate radiotherapy environment. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 985, 164662.

Montgomery, L., Landry, A., Al Makdessi, G., Mathew, F., & Kildea, J. (2020). A novel MLEM stopping criterion for unfolding neutron fluence spectra in radiation therapy. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 957, 163400.

Awards

CIRMS Junior Investigator Award (2020)

McGill - Graduate Excellence Award (2017)

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