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UID:20260601T063013EDT-8603OJC9vH@132.216.98.100
DTSTAMP:20260601T103013Z
DESCRIPTION:PhD Oral Defence of Najmeh Nikpour\, Parasitology\n\nOne of the
  most intriguing features of Trypanosoma brucei\, a unicellular protozoan 
 parasite\, is its unique way of energy production in different life cycle 
 stages. In the mammalian host\, trypanosomes generate energy by glycolysis
  in glycosomes whereas in the insect vector they generate energy by oxidat
 ive phosphorylation in mitochondria. In mitochondria\, mRNAs undergo a uni
 que post-transcriptional editing process by guide RNA-dependent insertion 
 and deletion of uridine nucleotides that requires a multi-protein complex\
 , the editosome. The edited mRNAs translate into the essential protein sub
 units of the respiratory chain. Interestingly\, RNA editing is differentia
 lly regulated between the mammalian and insect life cycle stages of the pa
 rasite\, resulting in differential mechanisms of ATP generation. However\,
  it is unknown how the developmental regulation of editing occurs. My Ph.D
 . project tested the hypothesis that differential editing may reflect the 
 differential function and/or composition of the components of the editosom
 e and its associated complexes in the different life cycle stages of the p
 arasite.\n\nEveryone in the McGill community is welcome to attend a PhD or
 al defence. Please join us in celebrating the accomplishments of our PhD c
 andidates.\n\n \n
DTSTART:20181112T181500Z
DTEND:20181112T181500Z
LOCATION:P-117\, Parasitology Building\, CA\, QC\, St Anne de Bellevue\, H9
 X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defence: The essential role of RBP7910 with Z-DNA domains 
 in U-indel editing
URL:https://www.mcgill.ca/macdonald/channels/event/phd-oral-defence-essenti
 al-role-rbp7910-z-dna-domains-u-indel-editing-290586
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