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UID:20260920T130834EDT-5825deBRux@132.216.98.100
DTSTAMP:20260920T170834Z
DESCRIPTION: \n\nPhD Oral Defense of Thangadurai Mani\, Institute of Parasi
 tology\n\nDirofilaria immitis is a filarial nematode that causes dirofilar
 iasis or heartworm in dogs\, cats\, wild canids and occasionally humans. E
 ffective control and prevention of this veterinary helminth\, as well as o
 ther helminths\, has been primarily by the administration of anthelmintics
  and it is still the most effective strategy to overcome parasitosis in th
 e veterinary field. One particular class of anthelmintics is the macrocycl
 ic lactones (MLs) and this drug class includes the avermectins and milbemy
 cins. MLs\, also referred as endectocides because of their remarkable effi
 cacy against ectoparasites and endoparasites\, are fermentation products o
 f different organisms.  For heartworm\, MLs are the only class of drugs us
 ed as preventives for more than 26 years. The continuous use of the MLs ha
 s led to drug resistance in many parasitic nematodes\, and in D. immitis\,
  ML resistance has very recently been confirmed. In heartworm\, although n
 o gene has been definitely implicated in ML resistance so far\, preliminar
 y evidence shows that the presence of two polymorphic loci on D. immitis P
 -glycoprotein-14 (Dim-Pgp-14) correlated with loss of efficacy of ML anthe
 lmintics\, suggesting that this Pgp may be involved in ML resistance. ABC 
 transporters such as Pgps modulate drug concentration at the target site a
 nd therefore can contribute to multidrug resistance. In many parasitic nem
 atodes\, this protein family has shown a consistent link with ML resistanc
 e. The first goal of this project was to characterize interaction of MLs\,
  namely ivermectin (IVM)\, selamectin (SEL)\, moxidectin (MOX) and milbemy
 cin oxime (MBO) with the expressed nematode transporter and to possibly un
 derstand the mechanism of ML resistance in D. immitis.\n\nEveryone in the 
 McGill community is welcome to attend a PhD oral defense. Please join us i
 n celebrating the accomplishments of our PhD candidates.\n\n \n\n \n
DTSTART:20160303T140000Z
DTEND:20160303T140000Z
LOCATION:MS2-022 (Fcaulty Lounge)\, Macdonald-Stewart Building\, CA\, QC\, 
 St Anne de Bellevue\, H9X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defense: Macrocyclic lactone interactions with a P-glycopr
 otein and polymorphism in ABC transporter and ion channel genes in Dirofil
 aria immitis
URL:https://www.mcgill.ca/macdonald/channels/event/phd-oral-defense-macrocy
 clic-lactone-interactions-p-glycoprotein-and-polymorphism-abc-transporter-
 258192
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