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UID:20261029T154706EDT-53496VLHAh@132.216.98.100
DTSTAMP:20261029T194706Z
DESCRIPTION:PhD Oral Defense of Vanessa Dufour\, Institute of Parasitology.
 \nFlatworms of the genus Schistosoma are wide-spread and clinically signif
 icant parasites of humans in the tropics and sub-tropics. Schistosomes exh
 ibit a two-host life cycle\, colonize the circulatory system of their defi
 nitive host and are dioecious (sexually dimorphic). In evolutionary terms\
 , they are representatives of the earliest metazoans to have evolved separ
 ate sexes\, and to possess anatomically distinct central and peripheral ne
 rvous systems. Schistosome infections are currently controlled by a single
  drug\, praziquantel (PZQ)\, but the emergence of schistosome strains resi
 stant to PZQ is a growing concern.  A deeper understanding of the basic bi
 ology of schistosomes is the first step towards target-based drug discover
 y\, an appealing approach to identify new lead candidates for schistosomia
 sis control.\nThe work presented in this thesis focuses on L-glutamate (L-
 glu) neuronal signaling in S. mansoni. L-glu is an important neurotransmit
 ter in essentially all vertebrate and invertebrate phyla\, but its functio
 nal roles in S. mansoni are poorly understood. Here\, we further contribut
 e to knowledge in this field by providing the first molecular evidence for
  the contribution of an inhibitory\, glutamate-gate Cl‑ channel (GluCl)-me
 diated component to glutamatergic neurotransmission in S. mansoni\, an unp
 recedented finding in parasitic flatworms.
DTSTART:20140306T141500Z
DTEND:20140306T141500Z
LOCATION:MS2-022\, Macdonald-Stewart Building\, CA\, QC\, St Anne de Bellev
 ue\, H9X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defense: Molecular characterization of novel glutamate-gat
 ed chloride subunits from Schistosoma mansoni
URL:https://www.mcgill.ca/macdonald/channels/event/phd-oral-defense-molecul
 ar-characterization-novel-glutamate-gated-chloride-subunits-schistosoma-23
 3268
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