4 o' Clock Forum: Understanding the molecular oxygen paradox

Thursday, November 30, 2023 16:00to17:00
Raymond Building R3-048, 21111 Lakeshore Road, St Anne de Bellevue, QC, H9X 3V9, CA

Progress in Understanding the Molecular Oxygen Paradox: Defining how mitochondria generate hydrogen peroxide for cell signaling and the redox regulatory mechanisms used to control its production

Join us at this 4 o'Clock Forum to hear from Professor Ryan Joshua Mailloux, Director of McGill's School of Human Nutrition discuss how cells make and regulate hydrogen peroxide to communicate with each other.

About the speaker

Ryan MaillouxProfessor Mailloux has established himself as a prominent mitochondrial bioenergeticist and redox biologist. His current research focuses on defining the major sources of mitochondrial hydrogen peroxide (mH2O2), its role in eliciting signals that are beneficial to cells, and how reversible redox modifications that are sensitive to antioxidant defense status, like glutathionylation and nitrosylation, modulate rates of mH2O2 generation. He has successfully shown enzymes like alpha-ketoglutarate dehydrogenase (KGDH) and pyruvate dehydrogenase (PDH) serve as vital mH2O2 sources for the maintenance of optimal liver health and that defects in the redox regulation of both enzymes can cause hepatic, cardiac, and metabolic diseases.

He has published 90 articles, has an h-index of 41, and his work has been cited over 5,200 times (SCOPUS) and is an executive member of the Canadian Oxidative Stress Consortium.

About the 4 o'Clock Forum Seminar Series

McGill's Faculty of Agricultural and Environmental Sciences has tremendous expertise and opportunities for innovations in research on agriculture, the environment, health, food, nutrition, pests and parasites, including from a biotechnology perspective. However, there are limited opportunities for faculty, postdoctoral fellows and graduate students to share their common interests in these areas.

In order to bring together the Macdonald Science Community, we have initiated a monthly seminar series—"4 O'clock Forum"—where faculty members and postdoctoral fellows are invited to present their work. Through these seminars on the Macdonald campus, researchers and graduate students will have regular opportunities to be exposed to scientific advancements related to their own fields of research as well as other scientific areas. Graduate and undergraduate students can benefit from these academic opportunities, all of which are aimed at stimulating critical discussions about contemporary research and issues in the agriculture and environment, to foster increased interactions among the Macdonald faculty, and to highlight our ability to deliver outstanding scientific contributions.

Please jaswinder.singh [at] mcgill.ca (contact Professor Jaswinder Singh) with any questions.

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