McGill.CA / Harrington Lab

Publications

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Journal Articles:

  1. Harrington, M.J. and Fratzl, P. (2020) Natural load-bearing protein materials. Progress in Materials Science. doi.org/10.1016/j.pmatsci.2020.100767.
  2. Song, G., Delroisse, J., Schoenaers, D., Horbelt, N., Kim, H. B., Nguyen, T. C., Leclère, P., Hwang, D. S., Harrington, M. J. and Flammang, P. (2020) Structure and composition of the tunic in the sea squirt Halocynthia roretzi: a complex cellulosic composite biomaterial. Acta Biomaterialia. 111, 290-301.
  3. Priemel, T. Palia, R., Babych, M., Thibodeaux, C., Bourgault, S. and Harrington, M. J. (2020) Compartmentalized processing of catechols during mussel byssus fabrication determines the destiny of DOPA. Proceedings of the National Academy of Science. 117, 7613-7621.
  4. Jehle, F., Macias-Sanchez, E., Sviben, S., Fratzl, P., Bertinetti, L. and Harrington, M. J. (2020) Biofabrication of functional meso-structured metallo-protein composites using co-existing condensed liquid phases. Nature Communications. 11, 862.
  5. Cerullo, A., Lai, T. Y., Allam, B., Baer, A., Barnes, W. J. P., Barrientos, Z., Deheyn, D. D., Fudge, D. S., Gould, J., Harrington, M. J., Holford, M., Hung, C.S., Jain, G., Mayer, G., Medina, M., Monge-Nájera, J., Napolitano, T., Espinosa, E. P., Schmidt, S., Thompson, E. M. and Braunschweig, A. B. (2020) Comparative animal mucomics: Inspiration for functional materials from ubiquitous and understudied biopolymers. ACS Biomaterials Science and Engineering. DOI: 10.1021/acsbiomaterials.0c00713.
  6. Pasche, D., Horbelt, N., Marin, F., Motreuil, S., Fratzl, P. and Harrington, M. J. (2019) Self-healing silk from the sea: Role of helical hierarchical structure in Pinna nobilis byssus mechanics. Soft Matter. 10.1039/C9SM01830A.
  7. Renner-Rao, M., Clark, M., and Harrington, M. J. (2019) Fiber formation from liquid crystalline collagen vesicles isolated from mussels. Langmuir. 10.1021/acs.langmuir.9b01932.
  8. Horbelt, N., Eder, M., Bertinetti, L., Fratzl, P. and Harrington, M. J. (2019) Unraveling the self-assembly process of stiff cellulosic fibers from mistletoe berries. Biomacromolecules. 10.1021/acs.biomac.9b00648.
  9. Baer, A., Oliveira, I.S., Schmidt, S., Harrington, M.J., and Mayer, G. (2019) Einblicke in den “Sekundenkleber” der Stummelfüßer. Biologie in unserer Zeit. 49, 418-425.
  10. Baer, A., Horbelt, N., Nijemeisland, M., Garcia, S.J., Fratzl, P., Schmidt, S., Mayer, G. and Harrington, M.J. (2019) Shear-induced beta-crystallite unfolding in condensed phase nanodroplets promotes fiber formation in a biological adhesive. ACS Nano 13, 4992-5001.
  11. Baer, A., Schmidt, S., Mayer, G. and Harrington, M.J. (2019) Fibers on the fly: Multiscale mechanisms of fiber formation in the capture slime of velvet worms. Integrative and Comparative Biology. 10.1093/icb/icz048.
  12. Tunn, I., Harrington, M. J., Blank, K. G. (2019) Bio-inspired histidine-Zn2+ coordination for tuning the mechanical properties of self-healing coiled coil-crosslinked hydrogels. Biomimetics 4, 25
  13. Zechel, S., Hager, M. D., Priemel, T. and Harrington, M. J. (2019) Healing through histidine: Bio-inspired pathways to self-healing polymers via imidazole-metal coordination. Biomimetics. 4, 20
  14. Tunn, I., de Léon, A.S., Blank, K.B. and Harrington, M.J. (2018) Tuning coiled coil stability with histidine-metal coordination. Nanoscale. DOI: 10.1039/C8NR07259K.
  15. Trapaidze, A., D’Antuono, M., Fratzl, P., Harrington, M.J. (2018) Exploring mussel byssus fabrication with peptide-polymer hybrids: Role of pH and metal coordination in self-assembly and mechanics of histidine-rich domains. European Polymer Journal. 109, 229-236.
  16. Baer, A., Hänsch, S., Mayer, G., Harrington, M.J. and Schmidt, S. (2018) Reversible supramolecular assembly of velvet worm adhesive fibers via electrostatic interactions of charged phosphoproteins. Biomacromolecules 19, 4034–4043.
  17. Harrington, M.J., Jehle, F. and Priemel, T. (2018) Mussel byssus structure-function and fabrication as inspiration for biotechnological production of advanced materials. Biotechnology Journal 13, 1800133.
  18. Pasche, D., Horbelt, N., Marin, F., Montreuil, S., Macias-Sanchez, E., Falini, G., Hwang, D.S., Fratzl, P. and Harrington, M.J. (2018) A new twist on sea silk: The peculiar protein ultrastructure of fan shell and pearl oyster byssus. Soft Matter DOI:10.1039/c8sm00821c.
  19. Jehle, F., Fratzl, P., Harrington, M.J. (2018) Metal-tunable self-assembly of hierarchical structure in mussel-inspired peptide films. ACS Nano. 12, 2160-2168.
  20. Montroni, D., Valle, F., Rapino, S., Fermani, S., Calvaresi, M., Harrington, M.J., Falini, G. (2018) Functional biocompatible matrices from mussel byssus waste. ACS Biomaterials Science and Engineering. 4, 57-65..
  21. Baer, A., Schmidt, S., Haensch, S., Eder, M., Mayer, G. and Harrington, M.J. (2017) Mechanoresponsive lipid-protein nanoglobules facilitate reversible fibre formation in velvet worm slime. Nature Communications 8, 974.
  22. Diba, M., Camargo, W., Brindisi, M., Farbod, K., Schmidt, S., Harrington, M.J., Draghi, L., Boccaccini, A., Jansen, J.A., van den Beucken, J.J.P. and Leeuwenburgh, S.C.G. (2017) Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects. Advanced Functional Materials 1703438.
  23. Fu J., Guerette, P.A., Pavesi, A., Horbelt, N., Lim, C.T., Harrington, M.J., and Miserez, A. (2017) Artificial hagfish protein fibers with ultra-high and tunable stiffness. Nanoscale 9, 12908-12915.
  24. Montroni, D., Piccinetti, C., Fermani, S., Calvaresi, M., Harrington, M.J. and Falini, G. (2017) Exploitation of mussel byssus mariculture waste as a water remediation material. RSC Advances 7, 36605-36611.
  25. Priemel, T., Degtyar, E., Dean, M.N., Harrington, M.J. (2017) Rapid self-assembly of complex biomolecular architectures during mussel byssus bio-fabrication. Nature Communications. 8, 14539.
  26. Enke, M., Jehle, F., Bode, S., Vitz, J., Harrington, M.J., Hager, M.D., Schubert, U.S. (2017) Histidine-zinc interactions investigated by isothermal titration calorimetry (ITC) and their application in self-healing polymers. Macromolecular Chemistry and Physics 1600458.
  27. Reinecke, A., Brezesinski, G., Harrington, M.J. (2017) pH-responsive self-organization of metal-binding protein motifs from biomolecular junctions in mussel byssus. Advanced Materials Interfaces. 4, 1600416.
  28. Reinecke, A., Bertinetti, L., Fratzl, P., Harrington, M.J. (2016) Cooperative behavior of a sacrificial bond network and elastic framework in providing self-healing capacity in mussel byssal threads. Journal of Structural Biology. 196, 329-339.
  29. Farbod, K., Diba, M., Zinkevich, T., Schmidt, S., Harrington, M.J., Kentgens, Leeuwenburgh, S.C.G. (2016) Gelatin Nanoparticles with Enhanced Affinity for Calcium Phosphate. Macromolecular Biosciences 16, 717-729.
  30. Harrington, M.J., Speck, O., Speck, T., Wagner, S., Weinkamer, W. (2016) Biological archetypes for self-healing materials. Advances in Polymer Science.273, 307-344.
  31. Schmitt, C.N.Z., Politi, Y., Reinecke, A., Harrington, M.J. (2015) The role of sacrificial protein-metal bond exchange in mussel byssal thread self-healing. Biomacromolecules 16, 2852-2861.
  32. Schmitt, C.N.Z., Winter, A., Bertinetti, L., Masic, A., Strauch, P., Harrington, M.J. (2015) Mechanical homeostasis of a DOPA-enriched biological coating from mussels in response to metal variation. Journal of the Royal Society Interface 12, 20150466.
  33. Degtyar, E., Mlynarczyk, B., Fratzl, P. and Harrington, M.J. (2015) Recombinant engineering of reversible cross-links into a resilient biopolymer. Polymer 69, 255-263.
  34. Enke, M., Bode, S., Vitz, J., Schacher, F.H., Harrington, M.J., Hager, M.D. and Schubert U.S. (2015) Self-healing response in supramolecular polymers based on reversible zinc-histidine interactions. Polymer 69, 274-282.
  35. Das, S., Miller, D.R., Kaufman, Y., Martinez-Rodriguez, N.R., Pallaoro, A., Harrington, M.J., Gylys, M., Israelachvili, J.N. and Waite, J.H. (2015) Tough coating proteins: subtle sequence variation modulates cohesion. Biomacromolecules 16, 1002–1008.
  36. Degtyar, E., Harrington, M.J., Politi, Y., Fratzl, P. (2014) Mechanical role of metal ions in biogenic protein-based materials. Angewandte Chemie 53, 12026-12044.
  37. Nabavi, S., Harrington, M.J., Fratzl, P. and Hartmann, M.A. (2014) Influence of sacrificial bonds on the mechanical behavior of polymer chains. Bioinspired, Biomimetic and Nanobiomaterials 3, 139-145.
  38. Schmidt, S., Reinecke, A., Wojcik, F., Pussak, D., Hartmann, L., Harrington, M.J. (2014) Metal-mediated molecular self-healing in histidine-rich mussel peptides. Biomacromolecules 15, 1644-1652.
  39. Poulsen, N., Kröger, N., Harrington, M. J., Brunner, E., Paasch, S. and Buhmann, M. (2014) Isolation and Biochemical Characterization of Underwater Adhesives from Diatoms. Biofouling 30, 513-523.
  40. Zedler, L., Hager, M.D., Schubert, U.S., Harrington, M. J., Schmitt, M., Popp, J. and Dietzek, B. (2014) Monitoring the chemistry of self-healing – current state and perspectives of the application of vibrational spectroscopy. Materials Today 17, 57-69.
  41. Guerette, P.A., Tay, G., Hoon, S., Loke, J.J., Hermawan, A.F., Harrington, M.J., Schmitt, C.N.Z., Masic, A., Gupta, H.S., Tan, K.S., Schwaighofer, A., Nowak, C., and Miserez, A. (2014) Integrative and comparative analysis of alpha-helical marine snail egg case - template for biomimetic elastomers. Biomaterials Science Journal DOI: 10.1039/c3bm60264h.
  42. Nabavi, S., Harrington, M.J., Paris, O., Fratzl, P. and Hartmann, M.A. (2014) The role of topology and thermal backbone fluctuations on sacrificial bond efficacy. New Journal of Physics 16, 013003.
  43. Holten-Andersen, N., Jaishankar, A., Harrington, M.J., Fullenkamp, D., DiMarco, V.,He, L., McKinley, G., Messersmith, P. B. and Lee, K. Y. C. (2014) Metal-coordination: Using one of nature’s tricks to control soft material mechanics. Journal of Materials Chemistry B 2, 2467-2472.
  44. Fischer, F.D., Harrington, M. J. and Fratzl P. (2013) Thermodynamic modeling of a phase transformation in protein filaments with mechanical function. New Journal of Physics 15, 065004.
  45. Krauss, S., Metzger, T.H., Fratzl, P. and Harrington, M.J. (2013) Self-repair of a biological fiber guided by an ordered elastic framework. Biomacromolecules 14, 1520-1528.
  46. Hwang, D.S., Harrington, M.J., Lu, Q., Masic, A., Zeng, H. and Waite, J.H. (2012) Mussel foot protein-1 (mcfp-1) interaction with titania surfaces. Journal of Materials Chemistry 22, 15530-15533.
  47. Harrington, M. J., Wasko, S.S., Masic, A., Gupta, H.S., Fischer, F.D. and Fratzl, P. (2012) Pseudoelastic behavior of a natural elastomeric proteinaceous material is achieved via reversible changes in backbone conformation. Journal of the Royal Society Interface 9, 2911-2922.
  48. Osorio-Madrazo, A., Eder, M., Rueggeberg, M., Pandey, J.K., Harrington, M.J., Nishiyama, Y., Putaux, J., Rochas, C., and Burgert, I. (2012) Re-orientation of cellulose nanowhiskers in agarose hydrogels under tensile loading.  Biomacromolecules 13, 850-856.
  49. Harrington, M.J., Razghandi, K., Ditsch, F., Guiducci, L., Rueggeberg, M., Dunlop, J.W.C., Fratzl, P., Neinhuis, C. and Burgert, I. (2011) Origami-like unfolding of hydro-actuated ice plant seed capsules. Nature Communications 2, 337.
  50. Holten-Andersen, N., Harrington, M.J., Birkedal, H., Lee, B.P., Messersmith, P.B., Lee, K.Y.C. and Waite, J.H. (2011) Mussel-inspired metal-ligand cross-links yield polymer gels with near covalent elastic moduli and self-healing properties. Proceedings of the National Academy of Science 108, 2651-2655.
  51. Hwang D.S., Zeng H., Masic A., Harrington M.J., Israelachvili, J.N. and Waite, J.H. (2010) Protein- and metal-dependent interactions of a prominent protein in mussel adhesive plaques. Journal of Biological Chemistry 285, 25850–25858.
  52. Harrington, M. J., Masic, A., Holten-Andersen, N., Waite, J. H., and Fratzl, P. (2010) Iron-clad fibers: a metal-based biological strategy for hard flexible coatings. Science 328, 216-220.
  53. Harrington, M. J., Gupta, H.S., Fratzl, P. and Waite, J. H. (2009) Collagen insulated from tensile damage by domains that unfold reversibly: In situ X-ray investigation of mechanical yield and damage repair in the mussel byssus. Journal of Structural Biology 167, 47-54.
  54. Harrington, M. J. and Waite, J. H. (2009). How nature modulates a fiber’s mechanical properties: Mechanically distinct fibers drawn from natural mesogenic block co-polymer variants. Advanced Materials 21, 440-444.
  55. Harrington, M. J. and Waite, J. H. (2008). pH-Dependent locking of giant mesogens in fibers drawn from mussel byssal collagens. Biomacromolecules 9, 1480-1486.
  56. Harrington, M. J. and Waite, J. H. (2007). Holdfast heroics: comparing the molecular and mechanical properties of Mytilus californianus byssal threads. Journal of Experimental Biology 210, 4307-4318.

Book Chapters:

  1. Reinecke, A. and Harrington, M.J. (2016). The role of metal ions in the mussel byssus. In: Saleuddin S.M. and Mukai, S.T., Eds. Physiology of Molluscs. Apple Academic Press.
  2. Harrington, M.J. and Waite, J.H. (2008). Short-order tendons: liquid crystal mesophases, metal-complexation and protein gradients in the externalized collagens of mussel byssal threads. In: Scheibel T,Ed. Fibrous Proteins. Austin:Landes Bioscience, 30-45.
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