McGill Alert / Alerte de McGill

Updated: Thu, 07/18/2024 - 18:12

Gradual reopening continues on downtown campus. See Campus Public Safety website for details.

La réouverture graduelle du campus du centre-ville se poursuit. Complément d'information : Direction de la protection et de la prévention.

Laetitia Laurent

Academic training

Jan-Aug 2017 | Post-doctoral fellow in Epigenetic and Reproduction, INRS-IAF (Laval, QC) and BCCHR (Vancouver, BC). Study of the effects of prenatal maternal stress on placental DNA methylation

2012- 2016 | Post-doctoral fellow in Toxicology and Reproduction, INRS-IAF (Laval, QC). Study of the effects of selective serotonin reuptake inhibitor on placental and fetal development

2007-2011 | PhD student in Neuroscience, IGF, University of Montpellier (Montpellier, France). Implication of the constitutive activity of the serotonin 4 receptor in feeding disorders and drug addiction

2005-2007 | MSc in Biology and Health. Professional training as Clinical Research Assistant



* Denotes equal contribution

1. Jean A., Laurent L., Delaunay S., Doly S., Dusticier N., Linden D. R., Neve R., Maroteaux L., Nieoullon A. and Compan V. Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia Following Stress, Cell Reports 21, 901–909, October 24, 2017. doi: 10.1016/j.celrep.2017.10.003

2. Laurent L.*, Deroy K.*, St-Pierre J., Côté F., Sanderson, J. T. and Vaillancourt C. Both peripheral and neuronal tryptophan hydroxylase synthetize serotonin in trophoblast cells. Biochimie, 2017 Jul 21. doi: 10.1016/j.biochi.2017.07.008

3. Hudon-Thibeault A., Laurent L., Sanderson, J. T. and Vaillancourt C. Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit. Mol Cell Endo, 2016 Nov 24. doi: 10.1016/j.mce.2016.11.021

4. Sagrillo-Fagundes L.*, Clabault H.*, Laurent L.*, Hudon-Thibeault A., Assunção Salustiano E., Fortier M., Bienvenue-Pariseault J., Wong Yen P., Sanderson, J. T. and Vaillancourt C. Human primary trophoblast cell culture model to study the protective effects of melatonin against hypoxia/reoxygenation-induced placental disruption. JoVE journal, 2016 Jul 30. doi :10.3791/54228

5. Laurent L.*, Huang C.*, Ernest SR., Berard A., Vaillancourt C. and Hales BF. In utero exposure to venlafaxine, a serotonin-norepinephrine reuptake inhibitor, increases cardiac anomalies and alters placental and heart serotonin signaling in the rat. Birth Defects Res A Clin Mol Teratol, 2016 Jul 7. doi: 10.1002/bdra.23537

6. Dallagi A., Girouard J., Hamelin-Morrissette J., Dadzie R., Laurent L., Vaillancourt C., Lafond J. and Reyes-Moreno C. The activating effect of IFNγ on monocytes/macrophages is regulated by the LIF trophoblast-IL10 axis through Stat1 inhibition and Stat3 activation. Cell Mol Immunol. 2014 Jul 14. doi: 10.1038/cmi.2014.50.

7. Jean A.*, Laurent L.*, Bockaert J., Charnay Y., Dusticier N., Nieoullon A., Barrot M., Neve R. and Compan V. The nucleus accumbens 5-HTR4-CART pathway ties anorexia to hyperactivity. Translational Psychiatry 2, e203; doi: 10.1038/tp.2012.131


8. St-Pierre J.*, Laurent L.*, King S. and Vaillancourt C. Effects of prenatal maternal stress on serotonin and fetal development. Trophoblast Research doi: 10.1016/j.placenta.2015.11.013

9. Compan V., Laurent L., Jean A., Macary C., Bockaert J. and Dumuis A. Serotonin signalling in eating disorders. WIREs Membr Transp Signal May 09 2012. doi: 10.1002/wmts.45

Book chapters

10. Clabault H.*, Laurent L.*, Sanderson, J. T. and Vaillancourt C. Isolation and purification of villous cytotrophoblast cells from term human placenta, Pre-Eclampsia: Methods and Protocols book, Methods in Molecular Biology, vol. 1710, 2017. doi: 10.1007\978-1-4939-7498-6

11. Sagrillo-Fagundes L., Laurent L., and Vaillancourt C. In vitro induction of hypoxia/reoxygenation on placental cells: A suitable model for understanding placental diseases, Pre-Eclampsia: Methods and Protocols book, Methods in Molecular Biology, vol. 1710, 2017. doi: 10.1007/978-1-4939-7498-6

12. Laurent L., Jean A., Manrique C., Najimi M., Chigr F. and Compan V. Anorexia and drugs of abuse abnormally suppress appetite, the result of a shared molecular signal foul-up. Animal model of eating disorders book (ed. N. Avena), vol. 74, Nov 01 2012, doi: 10.1007/978-1-62703-104-2_19, Springer Science and Business Media LLC, Humana Press.

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