I was born in Buenos Aires, Argentina, and moved to Canada in 2004. In Vancouver, BC, I pursued my undergraduate studies in Biological Sciences at Simon Fraser University (SFU). At SFU, I obtained my first research experience under the supervision of Dr. Gordon Rintoul and developed a great interest in the field of neurophysiology while studying mitochondrial dynamics in neurons and astrocytes in the context of stroke. Later, I moved East to Montreal and joined Dr. Przemyslaw Sapieha ’s new laboratory at Maisonneuve-Rosemont Hospital to pursue graduate studies (M.Sc.) at the Department of Biochemistry and Molecular Medicine in the Université de Montréal. In Dr. Sapieha’s lab, I studied the interaction of neurons, vessels and the immune system in the pathophysiology of diabetic retinopathy and other retinal pathologies.
Following my master’s training, I worked at the Lady Davis Institute for Medical Research (Jewish General Hospital) in Dr. R. Aloyz ’s lab (Oncology, McGill), where we investigated the metabolic profile and rewiring of primary B-lymphocytes in chronic lymphocytic leukemia (CLL). By understanding CLL B-cell bioenergetics, we sought to co-opt their metabolic features to resensitize B-cells to already approved drugs via combination therapy with metabolism targeting drugs.
Through the study of the pathophysiology of stroke, several diabetic complications and leukemia, I became deeply interested in the epidemiological and clinical implications of these and other non-communicable chronic diseases.
As part of my doctoral training in Epidemiology at McGill University, I am currently applying and combining my experience in fundamental and translational research with genetic epidemiology in order to elucidate genetic determinants of several chronic diseases.
Doctoral (Ph.D.) Student (Sep 2015 – Present)
Dept. of Epidemiology, Biostatistics and Occupational Health - McGill University, Montreal, Canada
Master of Science (M.Sc.) (Sep 2010 - Aug2013)
Dept. of Biochemistry and Molecular Medicine - University of Montreal (UdeM), Montreal, Canada
Dean of the Faculty of Medicine, Honours List
Bachelor of Science, Honours in Biology (Neurophysiology) (Sep 2004 - Apr 2009)
Dept. of Biological Sciences - Simon Fraser University, Vancouver, BC, Canada
Baccalaureate Specialized in Biological and Health Sciences (Mar 1998 - Dec 2003)
Colegio Nacional de Buenos Aires (University of Buenos Aires), Buenos Aires, Argentina
Miloudi, K., Binet, F., Wilson, A., Cerani, A., Oubaha, M., Menard, C., ... & Sapieha, P. (2016). Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. The Journal of clinical investigation, 126(8), 3006-3022.
Dejda, A., Mawambo, G., Cerani, A., Miloudi, K., Shao, Z., Daudelin, J. F., ... & Sapieha, P. (2014). Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk. The Journal of clinical investigation, 124(11), 4807-4822. doi: 10.1172/JCI76492
Miloudi, K., Dejda, A., Binet, F., Lapalme, E., Cerani, A., & Sapieha, P. (2014). Assessment of vascular regeneration in the CNS using the mouse retina. JoVE (Journal of Visualized Experiments), (88), e51351-e51351. doi: 10.3791/51351
Cerani, A., Tetreault, N., Menard, C., Lapalme, E., Patel, C., Sitaras, N., ... & Sapieha, P. (2013). Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell metabolism, 18(4), 505-518. doi: 10.1016/j.cmet.2013.09.003 Featured Article
Binet, F., Mawambo, G., Sitaras, N., Tetreault, N., Lapalme, E., Favret, S., ... & Juan, A. M. (2013). Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Cell metabolism, 17(3), 353-371. doi: 10.1016/j.cmet.2013.02.003