GCI Paper Highlight - MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway

An unbiased kinase screen reveals that Ras-driven cancer cells can bypass senescence by activating the Hippo pathway via MOB3A.

David Dankort’s lab’s latest paper in @MCR_AACR identifies the Hippo pathway inhibitor MOB3A as a novel suppressor of RAS and BRAF oncogene-induced senescence. Re-engagement of the Hippo pathway by MOB3A targeting could prove effective in the context of Ras-driven tumours.

Read the paper here.


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