PhD in Clinical and Translational Research (CTR)

PhD Degree in Clinical and Translational Research (formerly Experimental Medicine)

The overall objective of this program is to train students in the in-depth analysis of fundamental, translational and/or clinical research. Students perform studies at diverse levels, from molecular, cellular, and tissue to whole animal, human, and population in order to elucidate mechanisms behind human diseases, leading to drug discovery. Students are trained to become research leaders in both academic and industrial settings.

Applicants for the PhD in Clinical and Translational Research must normally hold an M.Sc. degree. The one exception is the possibility of direct entry offered to candidates having demonstrated academic excellence, i.e., a CGPA of 3.7 or more out of a possible 4.0 throughout their undergraduate studies.

For additional information, please refer to the timeline for the Ph.D. Program from admission to final thesis submission: PDF icon Ph.D. Timeline

Program Requirements

*For students who began the PhD program prior to Fall 2026, please see program requirements for the PhD in Experimental Medicine*

A PhD Degree in Division of Clinical and Translational Research requires the student to:

  • If entering with Master’s degree, complete 12 course credits at the 500+ level, which includes EXMD 634, one methods-based course, and 2 electives.
  • If entering with a BSc or MD or having been fast-tracked, complete 18 course credits, which includes EXMD 634, one methods-based course, and 4 electives.
  • Hold annual thesis committee meetings
  • Successfully complete the oral comprehensive exam
  • Submit a thesis based on their research that is passed by either an internal and external examiner.

Time and Fee Requirements

  • The PhD Program at McGill University requires a minimum residence of four full-time terms if admitted at the PhD 2 level, and 6 full-time terms if admitted at the PhD 1 level. 
  • PhD students are required to pay a minimum of 6 full-time terms (if admitted as PhD 2) and 8 full-time terms (if admitted to PhD 1). If degree requirements are met prior to completion of the residency year (PhD 3), fees for outstanding residency terms will be charged in the final term of registration.
  • Please refer to PhD Program Progression | Graduate and Postdoctoral Studies - McGill University
  • For further information on Tuition & Fees, please refer to the following link

Course Requirements (12-18 credits)

Required Courses

EXMD 634. Quantitative Research Methods.

Credits: 3
Offered by: Medicine (Graduate Studies)
Terms offered: Fall 2026
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Description

Topics covered include: 1) An overview of common research designs based on examples from research currently undertaken in the Division of Experimental Medicine; 2) Types of data arising from these designs; 3) Basic methods for data analysis; and 4) Application of these methods to student research projects.
  • Restriction: Must be registered for graduate or postdoctoral studies in the Faculty of Medicine or the Faculty of Science.

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EXMD 701. Comprehensive Oral Examination.

Credits: 0
Offered by: Medicine (Graduate Studies)
Terms offered: Fall 2026, Winter 2027
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Description

An examination that must be passed by all doctoral candidates in order to continue in the doctoral program.

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3 credits

0 credits

Complementary Course

Choose 3 credits from the following

EXMD 510. Bioanalytical Separation Methods.

Credits: 3
Offered by: Medicine (Faculty of Science)
Terms offered: Fall 2026
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Description

The student will be taught the capabilities and limitations of modern separation methods (gas and high-performance liquid chromatography, capillary electrophoresis, hyphenated techniques). Application of these techniques to solve analytical problems relevant to biomedical research will be emphasized, with special attention being paid to the processing of biological samples.
  • Fall

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EXMD 521. Computational Methods Single-Cell Analytics.

Credits: 3
Offered by: Medicine (Faculty of Medicine & Hlth Sci)
Terms offered: Fall 2026
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Description

Computational methods (particularly machine learning methods) for various single-cell data analysis, modelling, and visualization tasks that could drive novel biomedical discoveries, focusing on “real-world” biomedical applications.
  • Prerequisites: MATH 203, MATH 223, MATH 323, one course in computer programming and additional background in Calculus and Probability is required (e.g., MATH 222, MATH 204), or permission of the instructor.
  • Restrictions: Not open to students who have taken or are taking BMDE 521.

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EXMD 600. Principles of Clinical Research.

Credits: 3
Offered by: Medicine (Graduate Studies)
Terms offered: Fall 2026
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Description

Foundations for conducting clinical research including the principles underlying clinical studies, an overview of key methods in clinical research and the critical interpretation of peer-reviewed literature.
  • There are no set prerequisites, but it is expected that the student will have some background in mathematics; understanding functions and basic algebra is essential.

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EXMD 602. Techniques in Molecular Genetics.

Credits: 3
Offered by: Medicine (Graduate Studies)
Terms offered: Winter 2027
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Description

Precise description of available methods in molecular genetics, and rationales for choosing particular techniques to answer questions posed in research proposals for targeting genes in the mammalian genome. Emphasis placed on analysis of regulation of gene expression and mapping, strategies for gene cloning. Course divided between lectures and student seminars.
  • Offered in conjunction with the Department of Experimental Medicine.
  • Prerequisite (Graduate): Admission by permission of instructor.

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EXMD 604. Recent Advances in Cellular and Molecular Biology 1.

Credits: 3
Offered by: Medicine (Graduate Studies)
Terms offered: Fall 2026
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Description

Recent aspects of cell and molecular biology, including cellular organelle structure and function, molecular genetics, gene expression regulation, DNA replication and protein trafficking.
  • Restriction: Not open to students who have taken EXMD 604D1/D2.
  • Offered in conjunction with the Université de Montréal: given Thursdays 16:00-18:00 at the Institut de Recherches Cliniques de Montréal, 110 Pine West.
  • The course is bilingual with abstracts in the other language supplied; more than half the lectures are in French.

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EXMD 605. Recent Advances in Cellular and Molecular Biology 2.

Credits: 3
Offered by: Medicine (Graduate Studies)
Terms offered: Winter 2027
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Description

Recent aspects of cell and molecular biology, includin signal transduction, cell growth and development, and immunology.
  • Restriction: Not open to students who have taken EXMD 604D1/D2.
  • Offered in conjunction with the Université de Montréal: given Thursdays 16:00-18:00 at the Institut de recherches cliniques de Montréal, 110 Pine West.
  • The course is mostly in English, but some lectures may be in French.

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EXMD 609. Cellular Methods in Medical Research.

Credits: 3
Offered by: Medicine (Graduate Studies)
Terms offered: Fall 2026
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Description

Different cellular methods used in biomedical research, including spectroscopic, microscopic and immunological techniques as well as statistics. Lectures, some demonstrations by faculty as well as short seminars given by the students.

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EXMD 610. Molecular Methods in Medical Research.

Credits: 3
Offered by: Medicine (Graduate Studies)
Terms offered: Winter 2027
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Description

Different molecular methods used in biomedical research, including chromatography, purification and analysis of proteins and nucleic acids, various techniques in molecular biology, transgenic technology, and stem cells. Lectures, some demonstrations, and short seminars given by the students.

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EXMD 616. Molecular and Cell Biology Topics.

Credits: 3
Offered by: Medicine (Graduate Studies)
Terms offered: Fall 2026
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Description

Structured and instructor-directed student presentations and discussions of recent advances in molecular and cellular biology. The course will reinforce the students' knowledge of currently major areas of investigation, with a focus on human disease and medical applications. Important recent publications will extend material from textbook and review articles.

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3 credits

Elective Courses

The remaining 6-12 credits should be selected in consultation with the primary supervisor. Courses may be taken outside the department at the 500 level or higher in medical and allied sciences. A list of courses offered by the Division can be found here. 6-12 credits

Total

For graduate students, the minimum acceptable grade in required courses is B- (65%). Total: 12-18 credits

Thesis Requirements

  • A thesis for the doctoral degree must constitute original scholarship and must be a distinct contribution to knowledge. It must show familiarity with previous work in the field and must demonstrate ability to plan and carry out research, organize results, and defend the approach and conclusions in a scholarly manner. The research presented must meet current standards of the discipline; as well, the thesis must clearly demonstrate how the research advances knowledge in the field. Finally, the thesis must be written in compliance with norms for academic and scholarly expression and for publication in the public domain.
  • The PhD Thesis should follow the guidelines and requirements outlined on the Graduate and Postdoctoral Studies website.
  • Thesis Submission Deadlines

For additional information, please refer to the timeline for the Ph.D. Program from admission to final thesis submission: PDF icon Ph.D. Timeline

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