Dr. Jacques Archambault

Academic title(s): 

Professor - Department of Microbiology and Immunology
Associate Member - Department of Medicine, Division of Experimental Medicine

Contact Information
Address: 

Lyman Duff Medical Building
3775 University Street,
Montreal, Qc, H3A 2B4

Phone: 
(514) 398-3485
Email address: 
jacques.archambault2 [at] mcgill.ca
Current research: 

My laboratory is interested in the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), two families of small DNA tumor viruses that are widespread in the human population and cause significant diseases. While oncogenic HPV types are the cause of most anogenital and oropharyngeal cancers, reactivation of HPyVs in immunosuppressed individuals can lead to different pathologies including viral-induced nephropathy in kidney transplant patients (BKPyV), progressive multifocal encephalopathy in multiple sclerosis patients under immunosuppressive drug therapy (JCPyV), and Merkel cell carcinoma (MCPyV), a rare but very aggressive type of skin cancer, to name a few. My laboratory has a particular interest in elucidating the mechanism used by these viruses to replicate their circular double-stranded DNA genome as episomes in the nucleus of infected cells. Functional genomics, proteomics and chemical biology approaches are used to identify cellular pathways targeted by these viruses. Another important aspect of our research is the development of high-throughput assays for the screening of small molecule inhibitors of viral replication as potential drug leads for the treatment of HPV and HPyV associated diseases

Projects: 
  1. Single-cell analysis of papillomavirus and polyomavirus DNA replication
  2. Identification of host factors needed for papillomavirus and polyomavirus genome replication
Selected publications: 
Research areas: 
Cancer
Infectious Diseases