John Antoniou

John Antoniou

Titles: 

Research Director, Division of Orthopaedic Surgery, Department of Surgery, McGill University

Professor, Division of Orthopaedic Surgery, Department of Surgery, McGill University

Professor, Experimental Surgery, Graduate and Post Doctoral Studies, McGill University

Staff, Orthopaedic Surgeon, SMBD - Jewish General Hospital, Montreal

Contact Information:

malevisatos [at] jgh.mcgill.ca

Website: http://www.shoulderhipknee.com

Tel: 514-340-8222 x 24615

Twitter: @JohnAntoniou3

Recent Publications:

Publications indexed on PubMed

 

Clinical Interests:

Hip and Knee Reconstruction

Research Interests:

Outcome of total hip arthroplasty

Diagnostic tool for intervertebral disc degeneration

Tissue engineering of the intervertebral disc

Area of Research:

  • Tissue engineering of the intervertebral disc
  • Quantitative magnetic resonance imaging as a diagnostic tool of intervertebral disc degeneration
  • Periprosthetic osteolysis in total hip arthroplasty

Summary of Work:

Low back pain is a disorder afflicting the elderly population and in which, intervertebral disc degeneration plays a major role. Thus, my first research goal consists in engineering a replacement nucleus pulposus tissue using a hudrogel with differentiated adult mesenchymal stem cells. Furthermore, we believe that detecting and quantifying non-invasively the matrix and biomechanical changes in disc degeneration is key to treating this disease at its early stage. We believe that quantitative Magnetic Resonance Imaging is such a tool. Finally, my third main research interest is the study of periprosthetic osteolysis and wear debris in hip bearings. Joint replacement surgery is the most effective therapy to treat the pain and disability of patients with osteoarthritis. Metal-on-metal articulations are attractive but generate wear particles. We are thus analyzing the oxidative stress and metal ions in blood of patients with metal-on-metal hip bearings to better understand the clinical relevance of raised blood metal ions in patients with these bearings.

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