Lisbet Haglund

 

Lisbet Haglund

 

Title:

Associate Professor of Surgery, McGill University

Associate Director, Experimental Surgery, McGill University

 

Area of Research: Orthopedic Surgery

Contact Information:

lisbet.haglund [at] orl.mcgill.ca (Email)  lisbet.haglund [at] orl.mcgill.ca

 

 

Recent Publications:

 

Tillgren V, Önnerfjord P, Haglund L and Heinegård D. The tyrosine sulfate rich domains of the LRR-proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin binding proteins including bioactive factors. J. Biol. Chem. 2009 Oct 16;284(42):28543-28553.
 
Haglund L, Bernier SM, Önnerfjord P and Recklies AD. Proteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage. Matrix Biol, 2008 Mar;27(2):107-118.
 
Haglund L, Ouellet J, and Roughley P. Variation in chondroadherin abundance and fragmentation in the human scoliotic disc. Spine (2009). Jun 15;34(14):1513-1518.

Interests:

  • Dedicated to basic spinal research focusing on:
    1) Evaluating the potential for disc repair in early to moderate stages of disc degeneration. The overall goal is to show that it is possible to restore the integrity of the degenerated disc matrix with biological means.
    2) To identify novel markers of early disc degeneration (other than those generated in the intervertebral disc as a consequence of ageing).
    3) Characterization of changes in protein composition of the extra cellular matrix from scoliotic discs compared to normal control discs. This study will increase the understanding of composition and function of the extracellular matrix and provide a link between biochemical composition and biomechanical properties in normal and pathophysiological conditions.
    The projects utilize a variety of techniques in protein biochemistry, and cell biology.