Available Projects with Supervisors

 

Dr. Sampath Kumar Loganathan

M.Sc./Ph.D. student positions available in McGill University (PDF download)

Loganathan lab at the Cancer Research Program, Research Institute of McGill University Health Centre is currently looking for motivated and enthusiastic graduate students to start in September 2021 or January 2022. The position will be funded for 5 years but the trainees will be expected to apply for external studentships.

The project involves developing head and neck cancer (HNSCC) mouse models to study oncological mechanisms, CRISPR-Cas9 screening in mouse models of HNSCC, genome profiling techniques etc.
For more information, https://science.sciencemag.org/content/367/6483/1264

Students can enter the graduate program currently through 1) Department of Otolaryngology, Head and Neck Surgery or 2) Experimental Surgery or in future through 3) Division of Experimental Medicine. Interested student should apply directly to sampath.loganathan [at] mcgill.ca by sending their CV, a cover letter explaining why they are interested in the lab and names of 3 references.

Sampath Kumar Loganathan Ph.D.
Assistant Professor Department of Otolaryngology,
Head and Neck Surgery Junior Scientist,
Cancer Research Program,
Research Institute of McGill University Health Centre Associate Member,
Department of Experimental Surgery Co-Director,
Head and Neck Cancer Research Laboratory McGill University
Email: sampath.loganathan [at] mcgill.ca
Lab website: loganathan.lab.mcgill.ca

 


Dr. Derek Rosensweig is presently recruiting for a student to start in January 2021

Project Description: Anterior cruciate ligament (ACL) injuries are common, leading to reduced mobility where surgical reconstruction is standard care. However, reconstructive surgery is costly and is linked to early onset osteoarthritis associated with irregular healing, loss of mechanical function or abnormal knee biomechanics. There is therefore a clinical need for improved repair strategies to enhance patient outcomes. The overall goal of this proposal is to combine adipose-derived stromal/stem cells (ASCs) with mechanically competent scaffolds for ligament repair applications. ASCs are attractive due to their multipotency, yet not much evidence exists for ligament repair. Two types of scaffolds will be prepared: Flexible thermoplastic 3D printed scaffolds coated with cell-seeded hydrogels (scaffold A) and bioprinted aligned scaffolds consisting of cell-seeded chitosan/alginate bioink (scaffold B). ASC viability and ligament matrix deposition will be assessed in vitro and compared to primary ACL cell controls (Obj1). Both scaffold types will be matured in a bioreactor under physiological mechanical strain and viability, mechanical properties and ligament matrix deposition will be assessed (Obj2). Finally, matured scaffolds will be implanted subcutaneously in a rat model and biocompatibility, immune reactivity and potential tissue generation will be determined (Obj3). These data may suggest novel roles for ASCs in tissue engineering ACL substitutes.

Expectation for the student:  To work on culturing adipose MSCs in chitosan bioink, bioprint in aligned constructs and test viability and matrix deposition as compared to those with primary ACL fibroblasts.

20 hours per week/ Non-thesis student should have some cell culture experience and understand techniques like PCR, western blot, immuno-fluorescence and fluorescence microscopy.

 


Dr. Rahul Gawri is presently recruiting students for the 2020-2021 academic year:

Gawri lab research program focuses on osteoimmunology and the role of immunocompetent cells specially mast cells in fracture healing and elucidating effective mechanisms to recruit these cells to the fracture site to facilitate accelerated healing. The laboratory is situated in the Montreal General Hospital.

The project will involve animal handling, cell cultures, qPCR, mitochondrial DNA analysis, immunoblotting. ELISA. The prospective student will have ample opportunities for personal and professional advancements and chance to work with a multidisciplinary collaborative team.

Please contact

Dr. Rahul Gawri rahul.gawri [at] mail.mcgill.ca
Or
Dr. Paul Martineau paul.martineau [at] mcgill.ca

 


Dr. Jason Harley

Projects with funding: Harassment in Surgical and Medical Education (funding available)

Topics willing to supervise: Emotions in surgical education, emotion regulation and coping with stress/burnout in surgical education, self- and co-regulated learning in surgical education, educational applications of VR/AR/MR in surgery, educational applications of AI in surgery, diversity and social issues in surgical training.

 


Dr. Lysanne Campeau’s lab is presently recruiting students for the 2020-2021 academic year:

Dr Campeau’s research program aims to uncover the pathophysiologic mechanisms of voiding dysfunction associated with diabetes and metabolic syndrome and develop innovative therapeutic targets by evaluating different potential receptors and pathways involved in the pathology. Our laboratory is located at the Lady Davis Research for Medical Research Institute. The team is composed of a research assistant and 2 to 3 full-time students, and 2 to 3 students in summer. Techniques used ranges from animal surgery and physiological recording (metabolic chambers, organ baths) to molecular biology (qPCR, MicroRNAs, plasmids) and more conventional protocols (immunoblotting, confocal microscopy, ELISA and enzymatic kits). Students have to handle animals (mice and rats) and culture cells (urothelial and smooth muscles, mostly).

Please contact Dr Campeau at lysanne.campeau.mcgill.ca
Or
Philippe Cammisotto at philippe.cammisotto.1 [at] ulaval.ca

 


Dr. Ivan Litvinov’s lab is presenting recruiting students for the 2020-2021 academic year:

Ectopic reactivation of normally silenced germ cell programs contributes to genomic instability, carcinogenesis and cancer progression in skin Cutaneous T-Cell Lymphomas (CTCL). CTCL are non-Hodgkin Lymphomas and are the most common lymphomas of the skin. Despite recent advances in research, these lymphomas are very difficult to diagnose/treat. It takes on average ~6 years to diagnose CTCL because it mimics other common skin rashes such as eczema and psoriasis. Also, the median survival in advanced stages is only 2-4 years. Our goal is to improve diagnosis/prognosis and treatment of CTCL. To achieve this, we must improve the molecular understanding of how CTCL arises as well as to discover novel diagnostic/prognostic markers and genes that we can target for treatment.

Recent evidence indicates that a number of programs that are usually only present in germline tissues (i.e., testis and ovaries) are abnormally re-expressed in cancers and, specifically, in CTCL. We are proposing to study how reactivation of these genes (e.g., LINE-1 retrotransposition, cancer testis/meiosis regulatory genes) arises in CTCL leading to increased genomic instability in cancer cells. We will systematically assess the expression patterns of these genes in online databases, in freshly-obtained from patients and immortalized CTCL cells. We will study the mechanism of action for these genes, how they promote genomic instability (increased tendency of developing mutations and alterations in the genome), how they can be regulated and used as novel diagnostic/prognostic markers. We will also study how they can be targeted by new and existing treatments.

At the end of this project we hope to be able to produce a reliable set of markers that can help shorten the time to diagnosis and help distinguish CTCL from eczemas, psoriasis and other benign skin rashes. Also, we hope to identify prognostic markers that will help identify patients that are at risk of disease progression requiring aggressive therapy. Finally, through this work we will learn how select important genes and retrotransposon reactivation could be targeted in patients in order to treat their disease.

For further information, please contact:

Dr. Ivan V. Litvinov, MD, Ph.D., FRCPC
Assistant Professor, Director of Research
RQS, Chercheur Boursier
Division of Dermatology,
McGill University Health Centre
President-Elect, Skin Research Group of Canada
https://www.skinresearchgroup.org


 

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