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UID:20260727T094900EDT-0235OtBuSK@132.216.98.100
DTSTAMP:20260727T134900Z
DESCRIPTION:3655 Promenade Sir William Osler – Meakins – Rm 521   ALL ARE W
 ELCOME!\n\nSYNOPSIS: Well-designed randomized controlled trials (RCTs) rep
 resent the gold standard for establishing the efficacy of new cancer thera
 pies because they can generate internally valid results. However\, barrier
 s to trial enrollment can lead to underrepresentation of particular patien
 t subgroups (e.g.\, older adults\, women\, racial/ethnic minorities) and l
 imit the external validity of trial findings. In contrast\, observational 
 data sources and epidemiologic methods can be used to estimate the effecti
 veness of cancer treatments in more generalizable populations treated in r
 outine care settings. Yet\, these studies are subject to unmeasured confou
 nding by indication and frailty\, which may ultimately threaten internal v
 alidity. This talk will provide an overview of various epidemiologic appro
 aches employed to assess cancer therapy effectiveness in real world popula
 tions and highlight a novel\, hybrid approach that draws upon both RCT and
  observational data sources.\n\nAs a motivating clinical example\, the tal
 k will focus on evaluating the comparative effectiveness of alternative ad
 juvant chemotherapies for the treatment of stage III colon cancer. OBJECTI
 VES: At the end of this seminar\, participants will be able to: 1) define 
 internal and external validity and discuss the relevance of these concepts
  to the interpretation of findings from RCTs and observational studies of 
 cancer therapies 2) describe the strengths and limitations of alternative 
 epidemiologic approaches for evaluating the comparative effectiveness of c
 ancer therapies using observational data sources 3) explain at a conceptua
 l level how RCT and observational data can be combined to effectively tran
 sport RCTs findings to target populations of patients in routine care \n
DTSTART:20170116T210000Z
DTEND:20170116T220000Z
LOCATION:3655 promenade Sir William Osler
SUMMARY:Alternative approaches for evaluating the comparative effectiveness
  of cancer therapies using real world data
URL:https://www.mcgill.ca/epi-biostat-occh/channels/event/alternative-appro
 aches-evaluating-comparative-effectiveness-cancer-therapies-using-real-wor
 ld-data-265031
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