Dr. Dilson Rassier

Professor/Dean - Faculty of Education, Canada Research Chair, Tier 1, in Muscle Biophysics
Dr. Dilson Rassier
Contact Information

475 Pine Avenue West
Montreal, Quebec H2W 1S4


514-398-4400 Ext 0558
Email address: 
dilson.rassier [at] mcgill.ca
Kinesiology and Physical Education
Muscle Physiology and Biophysics Lab
Areas of expertise: 

Muscle physiology and biophysics.


B.P.E.(Fed. de Pelotas), M.Sc.(UFRGS), Ph.D.(Calg.)

Selected publications: 
  1. Shalabi N, Cornachione A, Leite FS, Vengallatore S, Rassier DE Residual force enhancement is regulated by titin in skeletal and cardiac myofibrils. The Journal of Physiology 2016 December 27. doi: 10.1113/JP272983.
  2. Rassier DE Reply to "Letter to the editor: Comments on Cornacchione et al. (2016): "The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms". American Journal of Physiology - Cell Physiology 2016 Jul 1; 311(1):C160-1. doi: 10.1152/ajpcell.00159.2016.
  3. Rassier DE, Minozzo FC Length-dependent Ca2+ activation in skeletal muscle fibers from mammalians. American Journal of Physiology - Cell Physiology 2016 Aug 1;311(2):C201-11. doi: 10.1152/ajpcell.00046.2016. Epub 2016 May 25.
  4. Leite FS, Kashina A, Rassier DE Posttranslational Arginilation Regulates Striated Muscle Function. Exercise and Sport Sciences Reviews 2016 Jul; 44(3):98-103. doi: 10.1249/JES.0000000000000079.
  5. Rassier, DE Reply to "Letter to the editor: Titin-actin interaction: the report of its death was an exaggeration".  American Journal of Physiology - Cell Physiology 2016 April 1; 310 (7):C 623. doi: 10.1152/ajpcell.00365.2015.
  6. Hussain SN, Cornachione AS, Guichon C, Al Khunaizi A, Leite FS, Petrof BJ, Mofarrahi M, Moroz N, de Varennes B, Goldberg P, Rassier DE. Prolonged controlled mechanical ventilation in humans triggers myofibrillar contractile dysfunction and myofilament protein loss in the diaphragm. Thorax 2016 May; 71(5):436-45. doi:10.1136/thoraxjnl-2015-207559. Epub 2016 Mar 31.
  7. Cheng AJ, Yamada T, Rassier DE, Andersson DC, Westerblad H, Lanner JT Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery. The Journal of Physiology 2016; doi:10.1113/JP270650.
  8. Rassier D E Two Kinases to Soften the Heart. Biophysical Journal 2016; Jan 19; 110 (2): 289-91. doi:10.1016/j.bpj.2015.12.007.
  9. Power GA, Minozzo FC, Spendiff S, Filion M E, Konokhova Y, Purves-Smith MF, Pion C, Aubertin-Leheudre M, Morais JA, Herzog W, Hepple R T, Taivassalo T, Rassier DE Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older masters athletes. American Journal of Physiology - Cell Physiology 2016 Feb 15;310(4):C318-27.doi:10.1152/ajpcell.00289.2015.Epub 2015 Dec 2.
  10. Leite FS, Minozzo FC, Kalganov A, Cornachione AS, Cheng Y S, Leu NA, Han X, Saripalli C, Yates JR 3rd, Grazier H, Kashina AS, Rassier DE Reduced passive force in scheletal muscles lacking protein arginylation. American Journal of Physiology - Cell Physiology 2016 Jan 15; 310(2):C127-35.doi:10.1152/ajpcell.00269.2015.Epub 2015 Oct 28.
  11. Cornachione, AS, Leite FS, Bagni, MA, Rassier, DE The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms. American Journal of Physiology - Cell Physiology 2016 Jan 1; 310(1):C19-26.doi; 10.1152/ajpcell.00156.2015. Epub 2015 Sep 24.
  12. Minozzo FC, Altman A, Rassier DE MgADP activation contributes to force enhancement during fast stretch of isolated skeletal myofibrils. Biochemical and Biophysical Research Communications 2015; Aug 19; 463(4):1129-34. Epub 2015 Jun 19.
  13. Trecarten N, Minozzo FC, Leite FS, Rassier D E Residual force depression in single sarcomeres is abolished by MgADP-induced activation. Scientific Reports. 2015; 3;5:10555. Epub 2015 Jun 3.
  14. Altman D, Minozzo F C, Rassier D E Thixotropy and rheopexy of muscle fibers probed using sinusoidal oscillations. PLoS One 2015; 16;10(4):e0121726. Epub 2015 Apr 16.
  15. Philippou A, Minozzo FC, Spinazzola JM, Smith LR, Lei H, Rassier DE, Barton ER Masticatory muscles of mouse do not undergo atrophy in space. The FASEB Journal. 2015; Jul 20; 29(7):2769-79.Epub 2015 Mar 20.
  16. Rassier DE, Leite FS, Nocella M, Cornachione AS, Colombini B, Bagni MA Non-crossbridge forces in activated striated muscles: a titin dependent mechanism of regulation? Journal of Muscle Research and Cell Motility. 36(1):37-45, 2015. [Epub ahead of print], Nov 25, 2014.
  17. Månsson A, Rassier DE, Tsiavaliaris G Poorly understood aspects of striated muscle contraction. BioMed Research International, 2014.
  18. Cornachione AS, Leite FS, Wang J, Leu NA, Kalganov A, Volgin D, Han X, Xu T, Cheng YS, Yates JR 3rd, Rassier DE, Kashina A Arginylation of Myosin heavy chain regulates skeletal muscle strength. Cell Reports. 24:8(2):470-476. 2014.
  19. Yamada T, Fedotovskaya O, Cheng AJ, Cornachione AS, Minozzo FC, Aulin C, Friden C, Turesson C, Andersson DC, Glenmark B, Lundberg IE, Rassier DE, Westerblad H, Lanner JT Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness. Annals of Rheumatic Diseases, Oct;74(10):1907-14. 2015. doi: 10.1136/annrheumdis-2013-205007. Epub 2014 May 22.
  20. Minozzo FC, Baroni B, Correa JA, Vaz MA, Rassier DE Force produced after stretch in sarcomeres and half-sarcomeres isolated from skeletal muscles. Scientific Reports, 3:2320, 2013.
  21. Minozzo FC, Rassier DE The effects of Ca2+ and MgADP on force development during and after muscle length changes. PLoS ONE, 8(7):e68866, 2013. 
  22. Ribeiro PAB, Ribeiro JP, Minozzo FC, Pavlov I, Leu NA, Kurosaka S, Kashina A, Rassier DE Contractility of myofibrils from the heart and diaphragm muscles measured with atomic force cantilevers: Effects of heart-specific deletion of arginyl-tRNA-protein transferase. International Journal of Cardiology 168(4):3564-3571, 2013. 
  23. Kalganov A, Shalabi N, Zitouni N, Kachmar LH, Lauzon AM, Rassier DE Forces measured with micro-fabricated cantilevers during actomyosin interactions produced by filaments containing different myosin isoforms and loop 1 structure. Biochimica et Biophysica Acta. 1830(3):2710-2719, 2013.
  24. Baroni BM, Rodrigues R, Franke RA, Geremia JM, Rassier DE, Vaz MA Time course of neuromuscular adaptations to knee extensor eccentric training. International Journal of Sports Medicine. Oct;34(10):904-11, 2013. doi: 10.1055/s-0032-1333263. Epub 2013 Mar 22.
  25. Bates G, Sigurdardottir S, Kachmar L, Zitouni NB, Benedetti A, Petrof BJ, Rassier DE, Lauzon AM Molecular, cellular, and muscle strip mechanics of the mdx mouse diaphragm. American Journal of Physiology - Cell Physiology. 304(9):C873-C880, 2013.
  26. Baroni BM, Rodrigues R, Franke RA, Geremia JM, Rassier DE, Vaz MA Time Course of Neuromuscular Adaptations to Knee Extensor Eccentric Training. International Journal of Sports Medicine. Mar 22. [Epub ahead of print], 2013.
  27. Rassier DE Residual force enhancement in skeletal muscles: one sarcomere after the other. Journal of Muscle Research and Cell Motility. 33(3-4):155-165, 2012.
  28. Kurosaka S, Leu NA, Pavlov I, Han X, Ribeiro PA, Xu T, Bunte R, Saha S, Wang J, Cornachione A, Mai W, Yates JR 3rd, Rassier DE, Kashina A Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 53(3):333-341, 2012.
  29. Rassier DE The mechanisms of the residual force enhancement after stretch of skeletal muscle: non-uniformity in half-sarcomeres and stiffness of titin. Proceedings of the Royal Society of London B, 279(1739):2705-2713, 2012.
  30. Minozzo FC, Hilbert L, Rassier DE Pre-power-stroke cross-bridges contribute to force transients during imposed shortening in isolated muscle fibers. PLoS One, 7(1):e29356, 2012.
  31. Cornachione A, Rassier DE A non-cross-bridge, static tension is present in permeabilized skeletal muscle fibers after active force inhibition or actin extraction. American Journal of Physiology – Cell Physiology, 302(3):C566-C574, 2012.
  32. Rassier DE, Pavlov I Force produced by isolated sarcomeres and half-sarcomeres after an imposed stretch. American Journal of Physiology – Cell Physiology, 302(1):C240-C248, 2012.
  33. Labuda A, Brastaviceanu T, Pavlov I, Paul W, Rassier DE Optical detection system for probing cantilever deflections parallel to a sample surface. Review Scientific Instruments, 82(1):013701, 2011.
  34. MacIntosh BR, Glumpak JJ, MacNaughton MB, Rassier DE Pattern of summation with fatigue and inhibition of calcium release in rat muscle. Muscle & Nerve, 44(3), 410–417, 2011.
  35. AP Safronov, M Shakhnovich, A Kalganov IA, Kamalov TF, Shklyar FA, Blyakhman G H Pollack DC electric fields produce periodic bending of polyelectrolyte gels. Polymer, 52:2430-2436, 2011.
  36. Kalganov A, Novinger R, Rassier DE. A technique for simultaneous measurement of force and overlap between single muscle filaments of myosin and actin. Biochemical and Biophysical Research Communications, 403(3-4):351-356, 2010.
  37. Minozzo F, Rassier DE Effects of blebbistatin and Ca2+ concentration on the force produced during stretch of skeletal muscle fibers. American Journal of Physiology – Cell Physiology, 299(5):C1127-1135, 2010.
  38. Pun C, Syed A, Rassier DE History-dependent properties of skeletal muscle myofibrils contracting along the ascending limb of the force-length relationship. Proceedings of the Royal Society of London B, 277:475-484, 2010.
  39. Pavlov I, Novinger R, Rassier DE Sarcomere dynamics in skeletal muscle myofibrils during isometric contractions. Journal of Biomechanics, 42(16):2808-2812, 2009.
  40. Pavlov I, Novinger R, Rassier DE The mechanical behavior of individual sarcomeres and half-sarcomeres isolated from skeletal muscles. American Journal of Physiology – Cell Physiology, 297(5): C1211-C1219, 2009.
  41. Rassier DE Molecular basis of force development by skeletal muscle during and after stretch. Molecular and Cellular Biomechanics, 6(4): 229-242, 2009.
  42. Rassier DE Pre-power-stroke cross-bridges contribute to force during stretch of skeletal muscle myofibrils. Proceedings of the Royal Society of London B, 275: 2577–2586, 2008.
  43. MacIntosh BR, Smith MJ, Rassier DE Staircase but not posttetanic potentiation in rat muscle after spinal cord hemisection. Muscle & Nerve, 38(5):1455-65, 2008.
  44. Joumaa V, Rassier DE, Leonard T, Herzog W The origin of passive force enhancement in skeletal muscle. American Journal of Physiology – Cell Physiology, 294(1):C74-C78. 2008.
  45. MacIntosh BR, Jones D, Devrome AN, Rassier DE Prediction of summation in incompletely fused tetanic contractions of rat muscle. Journal of Biomechanics, 40(5): 1066-1072, 2007.
  46. Joumaa V, Rassier DE, Leonard T, Herzog W Passive force enhancement in single myofibrils. Pflügers Archiv - European Journal of Physiology, 455(2): 367-371, 2007.
  47. Bullimore SR, Leonard TR, Rassier DE, Herzog W History-dependence of isometric muscle force: Effect of prior stretch or shortening amplitude. Journal of Biomechanics, 40(7): 1518-1524, 2007.
  48. Frasson VB, Rassier DE, Herzog W, Vaz MA Dorsiflexor and plantarflexor torque-angle and torque-velocity relationships of classical ballet dancers and volleyball players. Br Journal of Biomechanics, 8(14):31-37, 2007.
  49. Herzog W, Lee EJ, Rassier DE Residual force enhancement in skeletal muscle. Journal of Physiology (London), 574(3): 635-42, 2006.
Research areas: 
Exercise Physiology
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