More from Vedat Verter's Recent Research

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Designing Risk‐Adjusted Therapy for Patients with Hypertension

Authors: Manaf Zargoush, Mehmet Gumus, Vedat Verter, Stella S. Daskalopoulou

Publication: Production and Operations Management, Forthcoming


Limited guidance is available for providing patient‐specific care to hypertensive patients, although this chronic condition is the leading risk factor for cardiovascular diseases. To address this issue, we develop an analytical model that takes into account the most relevant risk factors including age, sex, blood pressure, diabetes status, smoking habits, and blood cholesterol. Using the Markov Decision Process framework, we develop a model to maximize expected quality‐adjusted life years, as well as characterize the optimal sequence and combination of antihypertensive medications. Assuming the physician uses the standard medication dose for each drug, and the patient fully adheres to the prescribed treatment regimen, we prove that optimal treatment policies exhibit a threshold structure. Our findings indicate that our recommended thresholds vary by age and other patient characteristics, for example (1) the optimal thresholds for all medication prescription are nonincreasing in age, and (2) the medications need to be prescribed at lower thresholds for males who smoke than for males who have diabetes. The improvements in quality‐adjusted life years associated with our model compare favorably with those obtained by following the British Hypertension Society's guideline, and the gains increase with the severity of risk factors. For instance, in both genders (although at different rates), diabetic patients gain more than non‐diabetic patients. Our sensitivity analysis results indicate that the optimal thresholds decrease if the medications have lower side‐effects and vice versa.


Published: 8 Aug 2018

Patient-centric design of long-term care networks

Authors: Paul Intrevado,  Vedat Verter and Lucie Tremblay

Publication: Health Care Management Science, Forthcoming


Published: 8 Jun 2018

Designing Risk-Adjusted Therapy for Patients with Hypertension

Authors: Manaf Zargoush, Mehmet Gumus, Vedat Verter, Stella Daskalopoulou

Journal Name: Production and Operations Management, Forthcoming


Hypertension has not been well studied by operations researchers from a clinical decision support perspective. Moreover, little personalized (i.e. patient-centric) guidance is available regarding the number and combination of antihypertensive medications. To fill this gap, we develop a Markov Decision Process (MDP) to characterize the optimal sequence (and combination) of antihypertensive medications under the standard medication dose. Our model is patient-centric as it takes into account a set of relevant patient characteristics such as age, gender, blood pressure level, smoking habits, diabetes status, and cholesterol level. Based on a set of intuitive assumptions, we prove that our model yields a series of structured optimal policies. Having calibrated our model based on real data and medical literature, we analyze these optimal policies and discuss their insights to the real practice. We also compare the benefits, in terms of quality adjusted life expectancy, QALE, obtained from our results with those obtained from British Hypertension Society (BHS) guideline.


Published: 20 Mar 2018

Did Europe Move in the Right Direction on E-Waste Legislation?

Authors: Shumail Mazahir, Vedat Verter, Tamer Boyaci and Luk van Wassenhove

Publication: Production and Operations Management, Forthcoming


This paper presents an analytical framework of the product take back legislation in the context of product reuse. We characterize existing and proposed forms of E-waste legislation and compare their environmental and economic performance. Using stylized models, we analyze an OEM’s decision about new and remanufactured product quantity in response to the legislative mechanism. We focus on the 2012 waste electrical and electronic equipment directive in Europe, where the policy-makers intended to create additional incentives for the product reuse. Through a comparison to the original 2002 version of the directive, we find that these incentives translate into improved environmental outcomes only for a limited set of products. We also study a proposed policy that advocates a separate target for the product reuse. Our analysis reveals that from an environmental standpoint, the recast version is always dominated either by the original policy or by the one that advocates a separate target for the product reuse. We show that the benefits of a separate reuse target scheme can be fully replicated with the aid of fiscal levers. Our main message is that there cannot be a single best environmental policy that is suitable for all products. Therefore, the consideration of product attributes is essential in identification of the most appropriate policy tool. This can be done either by the implementation of different policies on each product category or by implementation of product based target levels.


Published: 19 Mar 2018

Hospital capacity management based on the queueing theory

Authors: Otavio Bittencourt, Vedat Verter, Morty Yalovsky

Publication: International Journal of Productivity and Performance


Published: 23 Feb 2018

An integrated framework for inventory management and transportation of refined petroleum products: Pipeline or marine?

Authors: Atiq W. Siddiqui, Manish R. Verma and Vedat Verter

Publication: Applied Mathematical Modelling, Vol. 55, 2018


Published: 9 Jan 2018

Designing distribution systems with reverse flows

Authors: Ayse Cilaci Tombus¸ Necati Aras, Vedat Verter

Publication: Journal of Remanufacturing, Vol. 7, No. 2-3, December 2017


Published: 23 Oct 2017

Integrated fleet mix and routing decision for hazmat transportation: A developing country perspective

Authors: Anand Kumar, Debjit Roy, Vedat Verter and Dheeraj Sharma

Publication: European Journal of Operational Research, Vol 264, No. 1, January 2018


Published: 10 Aug 2017

Managing Patient Admissions in a Neurology Ward

Authors: Saied Samiedaluie, Beste Kucukyazici, Vedat Verter, Dan Zhang

Publication: Operations Journal


Published: 3 Jul 2017

Restructuring the resident training system for improving the equity of access to primary care

Authors: Anna Graber-Naidich, Michael W. Cartera, Vedat Verter

Publication: European Journal of Operational Research, Volume 258, Issue 3, 1 May 2017, Pages 1143–1155


Published: 20 Apr 2017

Evaluating the role of simulation in healthcare innovation: recommendations of the Simnovate Medical Technologies Domain Group

Authors: Madani, A., Gallix, B., Pugh, C.M.,  Azagury, D., Bradley, P., Fowler, D., Hannaford, B., Macdonald, S...

Published: 31 Mar 2017

Facility Location and Capacity Acquisition under Carbon Tax and Emissions Limits: To Centralize or To Decentralize?

Authors: Turken, N.,  Carrillo, J., Verter, V.

Publication: International Journal of Production Economics


Published: 22 Mar 2017

Congratulations to Professor Vedat Verter on receiving a CIHR/SSHRC Healthy and Productive Work Partnership Development Grant

Congratulations to Professor Vedat Verter (Co-investigator) on receiving a CIHR/SSHRC Healthy and Productive Work Partnership Development Grant for, Strengths-Based Nursing Management and Leadership Training with Innovative Story-sharing. This program is very competitive; of the 20 grants awarded, McGill University was granted one.

Published: 16 Sep 2016

Impact of train makeup on hazmat risk in a transport corridor

Authors: Cheng, J., Verma, M., Verter, V.

Publication: Journal of Transportation Safety and Security

Published: 5 Aug 2016

Designing personalized treatment: An application to anticoagulation therapy

Authors: Ibrahim, R., Kucukyazici, B., Verter, V., Gendreau, M., Blostein, M.

Published: 25 May 2016