maryam.tabrizian [at] mcgill.ca (Email)
Tel. (514) 398-8129
Website, Biomaterials Research Group
Professor Tabrizian received her PhD in Physical Sciences from Univ. P. et M. Curie and École de Physicochimie de Paris (France) in 1990. Her postdoctoral fellowship was conducted in the Center for Sciences and Engineering of Macromolecules at Laval University (90-92). She joined the Department of Biomedical Engineering and Faculty of Dentistry at McGill University in December 2000. She is FRSQ chercheure-Nationale awardee and the founder of the FQNRT Centre for Biorecognition and Biosensors (CBB) that she directed from 2002 to 2011. She became the Guggenheim fellow in 2010 and International Fellow of the Biomaterials Science & Engineering 2011 for her contribution to the field of biomedical sciences and engineering.
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The development of novel interface for improved interaction of biomaterials with biological environment is the overall objective of our research. We aim at building a deeper understanding of cell-biomaterial interactions in order improve our ability to predict and control the host response to new material. This is carried out through design, fabrication and characterization of multifunctional and bioactive surfaces as well as developing methodologies and protocols for creating these new biointerfaces. Our motivation rises from our belief that the future of biomedical devices will exploit materials surfaces that are designed on the basis of engineering principles to mimic the way that nature does it. As such, our laboratory masters a broad expertise in surface modification techniques, namely chemical, molecular assembly and biological methods to cope with the highly divergent requirements for surface properties in biomedical applications. Our target applications are mainly focused on regenerative medicine, nanomedicine and Lab-on-a-Chip platforms.
Examples of our ongoing research activities:
- Cell-cell and cell-biomaterial interactions.
- Layer-by-Layer self-assembly as bioactive interface on artificial and biological nanoparticulate templates for imaging, molecular therapy and tissue engineering.
- 3D and 2D biocompatible hydrogels and sponges for molecular therapy and tissue engineering.
- Surface molecular engineering and nanopatterning for biorecognition systems
- Microfluidic platform and Lab-on-a-Chip devices for genomic, proteomic, cell sorting and cell culturing.
- Non-invasive and real-time assessment of cell and tissue growth in microenvironment
Publications Last 5 Years (Trainee, *Corresponding Author)
T. Fatanat Didar, K. Li, M. Tabrizian*, T. Veres* (2013), “High throughput multilayer microfluidic particle separation platform using embedded thermoplastic-based micro-pumping”, Lab Chip 2013 May 3. [Epub ahead of print]
T. Fatanat Didar, K. Li, T. Veres*, M. Tabrizian* (2013), “Separation of rare oligodendrocyte progenitor cells from brain using a high-throughput multilayer thermoplastic-based microfluidic device”, Biomaterials. 2013 Apr 26. doi:pii: S0142-9612(13)00458-4 [Epub ahead of print]
K. Heileman, J. Daoud, Maryam Tabrizian* (2013), “Dielectric spectroscopy as a viable biosensing tool for cell and tissue characterization and analysis”, Biosensors and Bioelectronics. [Epub ahead of print]
L. H. Chan-Chan, C. Tkaczyk, R. F. Vargas-Coronado, J. M. Cervantes-Uc, M. Tabrizian, J. V. Cauich-Rodriguez (2013), “Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders”, J Mater Sci Mater Med. 2013 Apr 25. [Epub ahead of print].
M. Mekhail, J. Daoud, G. Almazan, M. Tabrizian* (2013), “Rapid, Guanosine 5'-Diphosphate-Induced, Gelation of Chitosan Sponges as Novel Injectable Scaffolds for Soft Tissue Engineering and Drug Delivery Applications”, Adv Healthc Mater. 2013 Apr 4. doi: 10.1002/adhm.201200371. [Epub ahead of print]
C. Holmes, M. Tabrizian, P. O. Bagnaninchi* (2013), “Motility imaging via optical coherence phase microscopy enables label-free monitoring of tissue growth and viability in 3D tissue engineering scaffolds", J Tissue Eng and Regenerative Medicine, 2013 Feb 12. doi: 10.1002/term.1687 [Epub ahead of print] .
C. Holmes, M. Tabrizian* (2013), “Substrate-Mediated Gene Delivery from Glycol-Chitosan/Hyaluronic Acid Polyelectrolyte Multilayer Films”, ACS Appl Mater Interfaces, 13;5(3):524-3.
N. Duceppe, M. Tabrizian* (2013), “Design and Development of Light-sensitive Chitosan-based Nanocarriers for Gene Delivery”, Advances in Science and Technology 86:75-80.
T. Fatanat Didar, M.Tabrizian* (2012), “Generating multiplex gradients of biomolecules for controlling cellular adhesion in parallel microfluidic channels”, Lab Chip. 12(21):4363-71.
A. Foudeh, T Fatanat Didar, T. Veres, M. Tabrizian* (2012), “Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics”, Lab Chip. 12(18):3249-66.
J. Daoud, K. Asami, L. Rosenberg, M. Tabrizian* (2012), “Dielectric Spectroscopy for Non-Invasive Monitoring of Epithelial Cell Differentiation Within Three Dimensional Scaffolds”, Phys Med Biol. 57(16):5097-112.
S. Saha S, C. Tomaro-Duchesneau, M. Tabrizian, S. Prakash* (2012), “Probiotics as oral health biotherapeutics. Expert Opin Biol Ther”. Jun 13. [Epub ahead of print]
L. Chan-Chan, R. Vargas-Coronado, U. J. Cervantes, J. Cauich-Rodríguez, R. Rath, E. Phelps E, A. García, J. S. Del Barrio, J. Parra , Y. Merhi, M. Tabrizian (2012), “Platelet adhesion and human umbilical vein endothelial cell cytocompatibility of biodegradable segmented polyurethanes prepared with 4,4'-methylenebis (cyclohexyl isocyanate), poly(caprolactone) diol and butanediol or dithioerythritol as chain extender”, J Biomater Appl. 2012 Jun 7. [Epub ahead of print]
M. Mekhail; G. Almazan, M. Tabrizian* (2012), “Oligodendrocyte-protection and remyelination post-spinal cord injuries: A Review”, Progress in Neurobiology, 96(3):322-339.
K. Bowey, J. F. Tanguay, M. Tabrizian* (2012), “Liposome technology for cardiovascular disease treatment and diagnosis”, Expert Opin Drug Deliv. 9(2):249-65.
C. Holmes, Tabrizian M* (2011), “Enhanced MC3T3 preosteoblast viability and adhesion on polyelectrolyte multilayer films composed of glycol-modified chitosan and hyaluronic acid”. J Biomed Mater Res A. 2011 Nov 29. [Epub ahead of print]
T. Fatanat Didar, A. M. Foudeh, M. Tabrizian* (2011), “Patterning Multiplex Protein Microarrays in a Single Microfluidic Channel”, Anal Chem 84(2):1012-8.
P. O. Bagnaninchi*, C. Holmes, N. Drummond, J. Daoud, M. Tabrizian (2011), “Two-dimensional and three-dimensional viability measurements of adult stem cells with optical coherence phase microscopy”, J Biomedical Optics, 16(8), ID- 086003.
L. Malic, M. G. Sandros, M. Tabrizian* (2011) “Designed Biointerface Using Near Infra-Red Quantum Dots for Ultrasensitive Surface Plasmon Resonance Imaging Biosensors”, Anal Chem 83(13):5222-9.
F. Azari, M. G. Sandros, M. Tabrizian* (2011), “Self-Assembled Multifunctional Nanoplexes for Gene Inhibitory Therapy”, Nanomedicine, 6(4):669-80.
J. Fatisson, S. Mansouri, D. Yacoubi, Y. Merhi, M. Tabrizian (2011), “Modeling Time Dependency Dissipation Factor Versus Frequency for Determination of Surface-Induced Platelet Activation». Journal of Royal Society Interface, 8(60):988-97.
S. Mansouri, Y. Merhi, F. M. Winnik, M. Tabrizian* (2011), “Layer-by-Layer assembled nanocoating strategy on red blood cells for immunocammouflage: A step towards the production of universal blood”, Biomacromolecules, 12(3):585-592.
J. Daoud, M. Petropavlovskaia, J. Patapas, C. Degrandpré, R. DiRaddo, L. Rosenberg, M. Tabrizian* (2011), “Long-Term In Vitro Human Pancreatic Islet Culture Using Three Dimensional Microfabricated Scaffolds”, Biomaterials, 32(6):1536-42.
L. Malic, T. Veres, T, M. Tabrizian* (2011), “Nanostructured digital microfluidics for enhanced surface plasmon resonance imaging”, Biosens Bioelectron. 26:2053-59.
J. Daoud, L. Rosenberg, M. Tabrizian* (2011), “Pancreatic Islet Culture and Preservation Strategies: Advances, Challenges, and Future Outlook”, Cell Transplantation, 19:1523-1535.
Critical Review: T. Fatanat-Didar, M. Tabrizian* (2010), “Adhesion based detection, sorting and enrichment of cells in microfluidic Lab-on-Chip devices”, Lab on a Chip, 10(22):3043-53.
Invited Review: N. Duceppe, M. Tabrizian* (2010), “Advances in using chitosan-based nanoparticles for in vitro andin vivo drug and gene delivery”, Expert Opin Drug Deliv 7(10), 1191-1207.
L. B. Khzam, A. Hachem, D. Yacoub, J-F. Theoret, G. Hassan, M. Tabrizian, W. Mourad, Y. Merhi* (2010), “Differential Responses of early and late endothelial progenitor cells to SCD40L”, Can J Cardiology, 26:141D-141D.
C. Tkaczyk, O. L. Huk, F. Mwale, J. Antoniou, D. J. Zukor, A. Petit, M. Tabrizian*,(2010), “Effect of chromium and cobalt ions on the expression of antioxidant enzymes in human U937 macrophage-like cells”, J. Biomed. Mat. Res A. 94(2):419-25.
C. Tkaczyk, O. L. Huk, F. Mwale, J. Antoniou, D. J. Zukor, A. Petit, M. Tabrizian*,(2010), “Investigation of the binding of Cr(III) complexes to bovine and human serum proteins: A Proteomic Approach ”, J Biomed Mater Res A. 94(1):214-22.
Z. S. Haidar, R. C. Hamdy, M. Tabrizian* (2010), “Biocompatibility and safety of a hybrid core-shell nanoparticulate OP-1 delivery system intramuscularly administered in rats”. Biomaterials 31(10):2746-54.
J. Daoud, M. Petropavlovskaia, L. Rosenberg, M. Tabrizian* (2010), “The effect of extracellular matrix components on the preservation of human islet function in vitro”, Biomaterials, 31(7):1676-82.
Z. Haidar, M. Tabrizian, R. Hamdy* (2010), "A hybrid rhOP-1 delivery system enhances new bone regeneration and consolidation in a rabbit model of distraction osteogenesis", Growth Factors, 28(1):44-55.
L. Malic,D. Brassard, T. Veres, M. Tabrizian* (2010), “Detection of biochemical assays in digital microfluidic LOC devices”, Lab on a Chip, 10(4):418-31.
S. Mansouri, J. Fatisson, Z. M. Miao Y. Merhi, F. M. Winnik, M. Tabrizian* (2009), “Silencing Red Blood Cell Recognition toward Anti-A Antibody by Means of Polyelectrolyte Layer-by-Layer Assembly in a Two-Dimensional Model System”, Langmuir, 25(24):14071-78.
D. Yacoub, A. Hachem, J-F. Theoret, G. Hassan, M. Tabrizian, W. Mourad, Y. Merhi* (2009), “Endothelial Progenitor Cells Bind and Inhibit Platelet Function and Thrombus Formation”, Circulation, 120(22):2230-9.
B. Khadro, BD Leca-Bouvier, F. Lagarde, L.J. Blum, C. Martelet, L. Marcotte, M. Tabrizian, N. Jaffrezic-Renault* (2009), “Chemiluminescence of Luminol for the Determination of Cobalt(II) Adsorbed on a Chitosan Membrane”, Sensor Letters 7(5): 833-38.
S. Faghihi, F. Azari, J. A. Szpunar, H. Vali, M. Tabrizian* (2009), “Titanium crystal orientation as a tool for the improved and regulated cell attachment”, J Biomed Mater Res A 91(3):656-62.
Z. S. Haidar, F. Azari, R. C. Hamdy, M. Tabrizian* (2009), “Modulated release of OP-1 and enhanced pre-osteoblast differentiation using a core-shell nanoparticulate system”, J Biomed Mater Res A 91(3):919-28.
L. Malic,B. Cui, M. Tabrizian,T. Veres*(2009) “imprinted Plastic Substrates for Enhanced Surface Plasmon Resonance Imaging Detection”, Optics Express, 17(22):20386-92.
(Invited Review) Z. Haidar, R. Hamdy, M. Tabrizian* (2009) “Recombinant BMP Delivery for Bone Regeneration and Repair- Part B: Delivery Systems for BMPs in Orthopaedic and Craniofacial Tissue Engineering”, Biotechnol Lett. 31(12):1825-35.
(Invited Review) Z. Haidar, R. Hamdy, M. Tabrizian* (2009) “Recombinant BMP Delivery for Bone Rege-eration and Repair, Part A: Current Challenges in BMP Delivery”, Biotechnol Lett. 31(12):1817-24.
M. Behrendt, M. G. Sandros, R. A. McKinney, K. McDonald, J. Kriz, E. Przybytkowski, M. Tabrizian, D. Maysinger* (2009), “Imaging and organelle distribution of fluorescent InGaP/ZnS nanoparticles in glial cells”, Nanomedicine, 4(7):747-61.
A. L. Hillberg, C. Holmes, M. Tabrizian* (2009) “Effect of Genipin Cross-linking on the Cellular Adhesion Properties of Layer-by-Layer Assembled Polyelectrolyte Films”, Biomaterials 30(27):4463-70.
X. D. Hoa, M. Tabrizian, A. G. Kirk* (2009), “Rigorous Coupled-Wave Analysis of Surface Plasmon Enhancement from Patterned Immobilization on Nano-Gratings”, Journal of Sensors, Vol. 2009, Article ID 713641, 7 pages.
X. D. Hoa, A.G. Kirk and M. Tabrizian* (2009), “Enhanced SPR Response from Patterned Immobilization of Surface Bioreceptors on Nano-gratings” Biosensors & Bioelectronics, 24(10):3043–48.
L. Malic, T. Veres, M. Tabrizian*, (2009), “Biochip functionalization using electrowetting-on-dielectric digital microfluidics for surface plasmon resonance imaging detection of DNA hybridization”, Biosens Bioelectron, 24(7):2218-24.
N. Duceppe, M. Tabrizian* (2009), “Factors influencing the transfection efficiency of ultra low molecular weight chitosan/hyaluronic acid nanoparticles”, Biomaterials, 30(13):2625-31.
(Invited Review) S. Mansouri, Y. Merhi, F. M. Winnik, M. Tabrizian* (2009), “Modulating the release kinetics through the control of the permeability of the layer-by-layer assembly: a review”, Exp Opinion on Drug Delivery, 6(6): 585-97.
G. Sydow-Plum, Z. S. Haidar, Y. Merhi, M. Tabrizian* (2008), “Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies”, Materials, 1 25-43.
L. Malic, T. Veres, M. Tabrizian* (2009), “Two-dimensional droplet-based surface plasmon resonance imaging using electrowetting-on-dielectric microfluidics”, Lab Chip, 9(3):473-5.
C. Tkaczyk, O. L. Huk, F. Mwale, J. Antoniou, D. J. Zukor, A. Petit, M. Tabrizian* (2009), “The molecular structure of complexes formed by chromium or cobalt ions in simulated physiological fluids”, Biomaterials, 30(4):460-7.
A. Dorris, K. Douglas, M. Tabrizian, C. Barett*, (2008) “Control of DNA incorporation into nanoparticles with poly-L-lysine multilayers”, The Canadian Journal of Chemistry, 86(12):1085-94.
X. D. Hoa, M. Martin, A. Jimenez, J. Beauvais, P. Charette, A. Kirk, M. Tabrizian* (2008), “Fabrication and Characterization of Patterned Immobilization of Quantum dots on Metallic Nano-gratings”, Biosensors and Bioelectronics, 24(4):976-81.
B. Thierry*, F. M. Winnik, Y. Merhi, H. Griesser, M. Tabrizian (2008), “Biomimetic Hemocompatible Coatings through Immobilization of Hyaluronan Derivatives on Metal Surfaces”, Langmuir, 24(20):11834-41.
G. Sydow-Plum, M. Tabrizian*(2008), “Review of stent coating strategies: clinical Insights”, Materials Science and Technology, 24(9): 1127-43.
(Invited Review) M. G. Sandros, C. B. Sarraf, M. Tabrizian* (2008), “Prodrugs in Cardiovascular Therapy, Molecules, 14:13(5):1156-78.
S. Faghihi, H. Vali, M. Tabrizian*(2008), “Effects of crystal size and orientation of substrates on cell adhesion: Implication for medical implants”, International Journal of Modern Physics B, 22(18-19): 3069-3081.
D. Brassard, L. Malic, F. Normandin, M. Tabrizian, T. Veres* (2008), “Water-oil core-shell droplets for electrowetting-based digital microfluidic devices”. Lab Chip, 8(8):1342-9.
M. Mandu-Hrit, E. Seifert, M. Kotsiopriftis, D. Lauzier, T. Haque, C. Rohlicek, M. Tabrizian, R. C. Hamdy* (2008), “OP-1 injection increases VEGF expression but not angiogenesis in a rabbit model of distraction osteogenesis", Growth Factors; 26(3):143-51.
M. Herrmann, T. Veres, M. Tabrizian* (2008), “Quantification of Low-Picomolar Concentrations of TNF-a in Serum Using the Dual-Network, Microfluidic ELISA Platform”, Anal Chem, 80(13):5160-7.
F. Azari, H. Vali, J-L. Guerquin-Kern, T-D Wu, A. Croisy, S. K. Sears, M. Tabrizian*, M. D. McKee* (2008), “Intracellular precipitation of hydroxyapatite mineral and implications for pathologic calcification”, J Struct Biol, 162:468–479.
A. L. Hillberg, M. Tabrizian* (2008), “Biomolecule imprinting: Developments in mimicking dynamic natural recognition systems”, ITBM-RBM 29:89–104.
L. Marcotte, M. Tabrizian* (2008), “Sensing surfaces: Challenges in studying the cell adhesion process and the cell adhesion forces on biomaterials”, ITBM-RBM 29:77–88.
K. Douglas, C. Piccirillo, M. Tabrizian* (2008), “Cell-Line Dependent Internalization Pathways and Intracellular Trafficking Determine Transfection Efficiency of Nanoparticle Vectors”, European Journal of Pharmaceutics, 68:676-687.
F. Burel*, L. Poussard, M. Tabrizian*, Y. Merhi, C. Bunel (2008), “The Influence of isocyanurate content on the bioperformance of hydrocarbon-based polyurethanes” JBS-Polymer edition, 19(4):525-40.
J. Fatisson, Y. Merhi, M. Tabrizian* (2008), “Quantifying blood platelet morphological changes by dissipation factor monitoring in multilayer shell”, Langmuir, 24(7):3294-9.
Z. S. Haidar, R. C. Hamdy, M. Tabrizian* (2008), “Core-shell hybrid nanoparticles through layer-by-layer assembly of alginate and chitosan on liposomes for protein delivery: Characterization and release kinetics”, Biomaterials, 29(9):1207-15.