Mervyn Gornitsky

mgornits [at] jgh.mcgill.ca (Email)

Dr. Mervyn Gornitsky

Professor Emeritus
Faculty of Dentistry
McGill University

Director of Research
Department of Dentistry
SMBD – Jewish General Hospital
3755 Côte Sainte-Catherine, A.017|
Montréal, Québec H3T 1E2

Phone: 514-340-7911

My current primary research themes are the discovery of salivary biomarkers in Parkinson’s disease and other neurological conditions, as well as evaluating the biomarkers and treatment of painful temporomandibular disorders and sleep apnea. My research venue is within the dental department of the Sir Mortimer B. Davis-Jewish General Hospital. Due to the large number of in-house consultations and out patients, we have a large group of cohorts from which to recruit for our various clinical studies.

In the past, my team has reported on epidemiologic studies associated with facial pain and bruxism, periodontal diseases in HIV positive and AIDS patients, xerostomia in patients undergoing radiotherapy for head and neck cancer, as well as the effects of oxidative stress on saliva. I am actively involved in the dissemination of findings from a nationwide, multi-site study on oral health status in systemic sclerosis, to patient groups and clinicians. Furthermore, in collaboration with Dr. Hyman Schipper, I developed the LDI/JGH Databank for Saliva Specimens. It currently contains approximately 4000 samples for the study of salivary biomarkers, and is located at the Lady Davis Institute (Jewish General Hospital). Our previous studies on salivary oxidative stress biomarkers assessed oxidative damage to lipids, proteins and DNA, in addition to total oxidative capacity, in various diseases, including periodontitis, scleroderma, diabetes, Alzheimer disease, and breast cancer. More information on the saliva databank can be found at http://www.ladydavis.ca/en/salivadatabase.

 

PUBLICATIONS

Song W, Kothari V, Velly A, Cressati M, Liberman A, Gornitsky M, Schipper HM. “Evaluation of Salivary Heme Oxygenase-1 as a Potential Biomarker of Early Parkinson’s Disease.” Movement Disorders. Accepted December 22, 2017

Baron M, Hudson M, Dagenais M, Macdonald D, Gyger G, El Sayegh T, Pope J, Fontaine A, Masetto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Fritzler M, Wang M, Gornitsky M. “Relationship Between Disease Characteristics and Oral Radiologic Findings in Systemic Sclerosis: Results From a Canadian Oral Health Study.” Arthritis Care & Research. 2016 May:68(5):673-680.

Gornitsky M, Velly AM, Mohit S, Almajed M, Su H, Panasci L, Schipper HM. “Altered Levels of Salivary 8-oxo-7-hydrodeoxyguanosine in Breast Cancer.” JDR Clinical & Translational Research. 2016 April;1:171-177. doi: 10.1177/2380084416642197.

Wang J, Schipper HM, Velly AM, Mohit S, Gornitsky M. “Salivary Biomarkers of Oxidative Stress: a Critical Review”. Free Radical Biology and Medicine 2015; 85:95–104 (Corresponding author)

Dagenais M, MacDonald D, Baron M, Hudson M, Tatibouet S, Steele R, Gravel S, Mohit S, El Sayegh T, Pope J, Fontaine A, Masseto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M.  “The Canadian Systemic Sclerosis Oral Health Study IV: Oral radiographic manifestations in systemic sclerosis compared with the general population” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2015 Aug: 120(2):104-11. (Corresponding author)

Baron M, Hudson M, Tatibouet S, Steele R, Lo E, Gravel S, Gyger G, El Sayegh T, Pope J, Fontaine A, Masseto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M. “The Canadian Systemic Sclerosis Oral Health Study III: Relationship Between Disease Characteristics and Oro-facial Manifestations in Systemic Sclerosis" Arthritis Care & Research, May 2015: 67(5):681-90.

Baron M, Hudson M, Tatibouet S, Steele R, Lo E, Gravel S, Gyger G, El Sayegh T, Pope J, Fontaine A, Masseto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M. “The Canadian systemic sclerosis oral health study II: The Relationship Between Oral and Global Health-Related Quality of Life in Systemic Sclerosis”. Rheumatology. April 2015: 54(4): 692-6

Baron M, Hudson M, Tatibouet S, Steele R, Lo E, Gravel S, Gyger G, El Sayegh T, Pope J, Fontaine A, Masseto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M. “The Canadian systemic sclerosis oral health study: orofacial manifestations and oral health-related quality of life in systemic sclerosis compared with the general population”. Rheumatology. August 2014; 53:1386-1394. (Corresponding author)

Taghzouti N,  Xiong X, Gornitsky M, Chandad F, Voyer R, Gagnon G, Leduc L, Xu H, Tulandi T, Wei B, Sénécal J, Velly AM, Salah MH, Fraser WD. “Periodontal disease is not associated with preeclampsia in Canadian pregnant women”. Journal of Periodontology. 2012 Jul; 83(7): 871

Su H, Velly AM, Salah MH, Benarroch M, Trifiro M, Schipper HM, and Gornitsky M. “Altered Redox Homeostasis in Human Diabetes Saliva”. Journal of Oral Pathology and Medicine. 2012 Mar;41(3):235-241.

Su H, Baron M, Benarroch M, Velly AM, Gravel S, Schipper HM, Gornitsky M. “Altered salivary redox homeostasis in patients with systemic sclerosis.” Journal of Rheumatology. Sep; 37(9):1858-63. 2010.

Baron M, Bernier P, Côté LF, Delegge MH, Falovitch G, Friedman G, Gornitsky M, Hoffer  J, Hudson M, Khanna D, Paterson WG, Schafer D, Toskes PP, Wykes L “Screening and therapy for malnutrition and related gastro-intestinal disorders in systemic sclerosis: recommendations of a North American expert panel.” Clinical & Experimental Rheumatology. 2010 Mar-Apr; 28(2 Suppl 58):S42-6.

Su H, Gornitsky M, Velly AM, Yu H, Benarroch M, Schipper HM. “Salivary DNA, lipid, and protein oxidation in non-smokers with periodontal disease.” Free Radical Biology & Medicine. 2009 Apr 1;46(7):914-21.

Su H, Gornitsky M, Geng G, Velly AM, Chertkow H, Schipper HM. ”Diurnal variations in salivary protein carbonyl levels in normal and cognitively impaired human subjects.”  AGE Vol. 30, No. 1.  1-9, Mar. 2008