Medical Student's Guide to the ICU - from the Society of Critical Care Medicine
Recently published studies of importance
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
Hébert P. C., Wells G., Blajchman M. A., Marshall J., Martin C., Pagliarello G., Tweeddale M., Schweitzer I., Yetisir E., The Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group
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N Engl J Med 1999; 340:409-417, Feb 11, 1999. Original Articles
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
The Acute Respiratory Distress Syndrome Network
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N Engl J Med 2000; 342:1301-1308, May 4, 2000. Original Articles
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
Bernard G. R., Vincent J.-L., Laterre P.-F., LaRosa S. P., Dhainaut J.-F., Lopez-Rodriguez A., Steingrub J. S., Garber G. E., Helterbrand J. D., Ely E. W., Fisher C. J., The Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group
[ Abstract ] [ Full Text ]
N Engl J Med 2001; 344:699-709, Mar 8, 2001. Original Articles
Intensive Insulin Therapy in Critically Ill Patients
Van den Berghe G., Wouters P., Weekers F., Verwaest C., Bruyninckx F., Schetz M., Vlasselaers D., Ferdinande P., Lauwers P., Bouillon R.
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N Engl J Med 2001; 345:1359-1367, Nov 8, 2001. Original Articles
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., Peterson E., Tomlanovich M., the Early Goal-Directed Therapy Collaborative Group
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N Engl J Med 2001; 345:1368-1377, Nov 8, 2001. Original Articles
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
Bernard S. A., Gray T. W., Buist M. D., Jones B. M., Silvester W., Gutteridge G., Smith K.
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N Engl J Med 2002; 346:557-563, Feb 21, 2002. Original Articles
Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock
Djillali Annane, MD, PhD; Véronique Sébille, PhD; Claire Charpentier, MD; Pierre-Edouard Bollaert, MD, PhD; Bruno François, MD; Jean-Michel Korach, MD; Gilles Capellier, MD, PhD; Yves Cohen, MD, PhD; Elie Azoulay, MD; Gilles Troché, MD; Philippe Chaumet-Riffaut, MD; Eric Bellissant, MD, PhD; JAMA. 2002;288:862-8
[ Abstract ] [ Full Text ] [ PDF (151K) ]
Physician Staffing Patterns and Clinical Outcomes in Critically Ill Patients: A Systematic Review
Peter J. Pronovost, MD, PhD; Derek C. Angus, MB, ChB, MPH; Todd Dorman, MD; Karen A. Robinson, MSc; Tony T. Dremsizov, MBA; Tammy L. Young
JAMA November 6, 2002; 288: 2151-2162
[ Abstract ] [ Full Text ] [ PDF (170K) ]
A Randomized, Controlled Trial of the Use of Pulmonary-Artery Catheters in High-Risk Surgical Patients
Sandham J. D., Hull R. D., Brant R. F., Knox L., Pineo G. F., Doig C. J., Laporta D. P., Viner S., Passerini L., Devitt H., Kirby A., Jacka M., the Canadian Critical Care Clinical Trials Group
N Engl J Med 2003; 348:5-14, Jan 2, 2003.
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Respiratory including ARDS and weaning
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
The Acute Respiratory Distress Syndrome Network
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N Engl J Med 2000; 342:1301-1308, May 4, 2000. Original Articles
Pulmonary Dead-Space Fraction as a Risk Factor for Death in the Acute Respiratory Distress Syndrome
Nuckton T. J., Alonso J. A., Kallet R. H., Daniel B. M., Pittet J.-F., Eisner M. D., Matthay M. A.
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N Engl J Med 2002; 346:1281-1286, Apr 25, 2002. Original Articles
Medical Progress: The Acute Respiratory Distress Syndrome
Ware L. B., Matthay M. A.
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N Engl J Med 2000; 342:1334-1349, May 4, 2000. Review Articles
Effect of Prone Positioning on the Survival of Patients with Acute Respiratory Failure
Gattinoni L., Tognoni G., Pesenti A., Taccone P., Mascheroni D., Labarta V., Malacrida R., Di Giulio P., Fumagalli R., Pelosi P., Brazzi L., Latini R., the Prone–Supine Study Group
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N Engl J Med 2001; 345:568-573, Aug 23, 2001. Original Articles
Effect of prolonged methylprednisolone therapy in unresolving ARDS: A randomized controlled trial.Meduri, Headley et al;JAMA 1998;280(2):159-165Click here for Medline link
Medical Progress: Advances in Mechanical Ventilation
Tobin M. J.
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N Engl J Med 2001; 344:1986-1996, Jun 28, 2001. Review Articles
A Comparison of Four Methods of Weaning Patients from Mechanical Ventilation
Esteban A., Frutos F., Tobin M. J., Alía I., Solsona J. F., Valverdu V., Fernández R., de la Cal M. A., Benito S., Tomás R., Carriedo D., Macías S., Blanco J., The Spanish Lung Failure Collaborative Group
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N Engl J Med 1995; 332:345-350, Feb 9, 1995. Original Articles
Cardiovascular
The effectiveness of right heart catheterization in the initial care of critically ill patients Connors AF,Speroff T, Dawson NV, Thomas C, Harrell FE, Wagner D, Desbiens N, Goldman L, Wu AW, Califf RM,Fulkerson WJ Jr, Vidalillet H, Broste S, Bellamy P, Lynn J, Knaus WA , JAMA 1996;276:889-897
High-dose epinephrine in adult cardiac arrest
Stiell I. G., Hebert P. C., Weitzman B. N., Wells G. A., Raman S., Stark R. M., Higginson L. A., Ahuja J., Dickinson G. E.
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N Engl J Med 1992; 327:1045-1050, Oct 8, 1992. Original Articles
Mechanisms of Disease: The Pathogenesis of Vasodilatory Shock
Landry D. W., Oliver J. A.
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N Engl J Med 2001; 345:588-595, Aug 23, 2001. Review Articles
Renal
Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Claudio Ronco, Rinaldo Bellomo, Peter Homel, Alessandra Brendolan, Maurizio Dan, Pasquale Piccinni, Giuseppe La Greca. LancetVolume 356 Issue 9223 Page 26
Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group*. Lancet 2000 Volume 356 Issue 9248 Page 2139-43.
Hyponatremia
Adrogué H. J., Madias N. E.
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N Engl J Med 2000; 342:1581-1589, May 25, 2000. Review Articles
Hypernatremia
Adrogué H. J., Madias N. E.
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N Engl J Med 2000; 342:1493-1499, May 18, 2000. Review Articles
Sepsis
Current Concepts: Treating Patients with Severe Sepsis
Wheeler A. P., Bernard G. R.
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N Engl J Med 1999; 340:207-214, Jan 21, 1999. Review Articles
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
Bernard G. R., Vincent J.-L., Laterre P.-F., LaRosa S. P., Dhainaut J.-F., Lopez-Rodriguez A., Steingrub J. S., Garber G. E., Helterbrand J. D., Ely E. W., Fisher C. J., The Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group
[ Abstract ] [ Full Text ]
N Engl J Med 2001; 344:699-709, Mar 8, 2001. Original Articles
Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock
Djillali Annane, MD, PhD; Véronique Sébille, PhD; Claire Charpentier, MD; Pierre-Edouard Bollaert, MD, PhD; Bruno François, MD; Jean-Michel Korach, MD; Gilles Capellier, MD, PhD; Yves Cohen, MD, PhD; Elie Azoulay, MD; Gilles Troché, MD; Philippe Chaumet-Riffaut, MD; Eric Bellissant, MD, PhD; JAMA. 2002;288:862-8
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., Peterson E., Tomlanovich M., the Early Goal-Directed Therapy Collaborative Group
[ Abstract ] [ Full Text ]
N Engl J Med 2001; 345:1368-1377, Nov 8, 2001. Original Articles
Intensive Insulin Therapy in Critically Ill Patients
Van den Berghe G., Wouters P., Weekers F., Verwaest C., Bruyninckx F., Schetz M., Vlasselaers D., Ferdinande P., Lauwers P., Bouillon R.
[ Abstract ] [ Full Text ]
N Engl J Med 2001; 345:1359-1367, Nov 8, 2001. Original Articles
Stress Ulcer Prophylaxis
A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation
Cook D., Guyatt G., Marshall J., Leasa D., Fuller H., Hall R., Peters S., Rutledge F., Griffith L., McLellan A., Wood G., Kirby A., Tweeddale M., Pagliarello J., Johnston R., The Canadian Critical Care Trials Group
[ Abstract ] [ Full Text ]
N Engl J Med 1998; 338:791-797, Mar 19, 1998. Original Articles
Risk Factors for Gastrointestinal Bleeding in Critically Ill Patients
Cook D. J., Fuller H. D., Guyatt G. H., Marshall J. C., Leasa D., Hall R., Winton T. L., Rutledge F., Todd T., Roy P., Lacroix J., Griffith L., Willan A., The Canadian Critical Care Trials Group
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N Engl J Med 1994; 330:377-381, Feb 10, 1994. Original Articles