Symposium 2005

Fifth Annual Quebec Parasitology Symposium, June 13-14, 2005 McGill University Health Centre Montreal General Hospital Site


The Osler Amphitheatre, Room A6-105

Monday June 13, 2005


8:00 – 8:45 Registration, Livingston Hall Lounge,
Room L6-500
Coffee and Refreshments available
9:00 – 9:15 Welcome: Mary Stevenson - Centre for the Study of Host Resistance
Terry Spithill – Institute of Parasitology

Molecular Biology and Biochemistry
Chair: Martin Olivier

19:15 AM – 12:30 PM

9:15 – 10:15 Malcolm J. Gardner (The Institute for Genomic Research)
Genome sequence of Theileria parva, a bovine pathogen causing a lymphoproliferative disease
10:15 – 10:30 Barbara Papadopoulou, F. McNicoll, M. Müller, A. Rochette (Centre de Recherche en Infectiologie de l'Université Laval)
Mechanisms of Translational Control in the Intracellular Stage of Leishmania
10:30 – 10:45 François McNicoll, J. Drummelsmith, M. Müller, M. Ouellette, B. Papadopoulou (Centre de Recherche en Infectiologie de l'Université Laval)
Proteomic Analysis of Stage-Specific Gene Expression in Leishmania infantum

10:45 – 11:15

Coffee , Livingston Hall Lounge,
Room L6-500

11:15 – 11:30 Pat Madrid and Armando Jardim ( Institute of Parasitology, McGill)
Molecular mapping of L. donovani PEX14 with the glycosomal membrane
11:30 – 11:45 Sabrina A. Smith and Armando Jardim (Institute of Parasitology, McGill)
Identification of a GMP Reductase in Leishmania donovani
11:45 – 12:00 Robert Lodge and Albert Descoteaux (INRS-Institut Armand- Frappier)
L. donovani amastigotes interfere with proper NADPH oxidase assembly at the phagosome membrane.
12:00 – 12:15 Mara L. Leimanis and Elias Georges (Institute of Parasitology, McGill)
Detection and Characterization of ABCG2 (BCRP/MXR/ABCP) as a Homodimer in Human Erythrocytes

12:30 – 2:00

Lunch, Livingston Hall Lounge,
Room L6-500
Poster Setup and Viewing

Drug Resistance and Chemotherapy
Chair: Scott Bohle

12:30 – 2:00 PM

2:00 – 2:30 Albert M. Berghuis (Dept of Biochemistry, McGill)
Resisting Resistance: Structural biology of aminoglycoside antibiotic resistance enzymes
2:30 – 2:45 Anne E.Schwab1, A.J.Schwab2., T.S. Churcher3, M.-G. Basanez3 and R.K.Prichard (1Institute of Parasitology, McGill; 2 McGill University Medical Clinic, McGill University Health Centre; 3Infectious Disease Epidemiology, Imperial College, London)
Analysis of the population genetics of concurrent selection with albendazole and ivermectin on the possible development of albendazole resistance
2:45 – 3:00 Jean Fotie and Scott D. Bohle (Dept. of Chemistry, McGill)
Medicinal plants as potential source of new antimalarial agents.
3:00 – 3:15 Cesar Miranda-Verástegui1,2,3, A. LIanos-Cuentas3, I. Arévalo1,2, A. Ghosh1., Theresa Gyorkos, B. Ward1,2 and G. Matlashewski1 (1Dept. of Microbiology and Immunology, McGill, and 2McGill Centre for Tropical Diseases, McGill University Health Center, and 3Instituto de Medicina Tropical Alexander von Humbolt, Universidad Peruana Cayetano Heredia)
Overview of the McGill, Cayetano Drugs for Neglected Diseases Program, Progress and Future

3:15 – 3:45

Coffee, Livingston Hall Lounge,
Room L6-500

Field Studies and Novel Diagnostics
Chair: Greg Matlashewski

3:45 – 5:15 PM

3:45 – 4:15 Gyorkos, Theresa and Renee Larocque (Dept Epidemiol Biostats, McGill; Div Clin Epidemiol, RI-MUHC (MGH)
Field trial of mebendazole plus iron versus placebo plus iron in second trimester pregnant women in a hookworm-endemic area of Peru 13
4:15 – 4:45 Marilyn Scott, Leslie Payne and Kris Koski (Institute ofParasitology and School of Dietetics and Human Nutrition, McGill)
Vitamin A Supplementation Reduces Reinfection Rates with Ascaris lumbricoides in Panamanian Preschool Children
4:45 – 4:50 Ndao M1, Rainczuk A1 , Caffrey R2, Li H2, Smith P2, McCaffrey J2, Spithill TW & Ward BJ1 (1National Reference Centre for Parasitology/McGill University, 2Ciphergen Biosystems Inc., Fremont, California)
Use of SELDI-TOF To Detect Blood-Borne Protozoan Infections
5:00 – 5:15 Lejon V, Ward B, Rainczuk A, Büscher P, Mumba D, Ndao M (NRCP, McGill, Montreal; ITM, Antwerp, Belgium; INRB, Kinshasa, Congo)
New perspectives for diagnosis and staging of human African trypanosomiasis using SELDI-TOF MS
5:15—5:30 Wen-Wei Zhang1, Cesar Miranda Verastegui1,2,3, Alejandro Lianos- Cuentas2, Brian Ward3 and Greg Matlashewski1 (1 Dept. of Microbiology and Immunology, McGill 3Department of Tropical Medicine, Montreal General Hospital Research Institute, McGill. 2 Instituto de Medicina Tropical ‘Alexander von Humboldt’, Lima, Peru)
Adapting multi-locus enzyme electrophoresis analysis into a genetic assay to distinguish between Leishmania (Viannia) braziliensis and L. (v) peruviana infections

5:15 – 7:30

Mixer and Dinner,
Livingston Hall Lounge, Room L6-500
Poster Viewing

Tuesday 14 June, 2005

Immunity Chair: Tatiana Scorza

9:00 AM – 12:30 PM

9:00 – 9:30 Ciriaco A. Piccirillo, Belkaid Y., K, Yurchenko, and M. Tritt. (Dept. of Microbiology and Immunology, McGill) CCR5 dependent control of L.major infection mediated by naturally-occurring CD4+CD25+ regulatory T cells.
9:30 – 9:45 Jean-Frédéric Flandin, Frédéric Chano and Albert Descoteaux (INRS-Institut Armand-Frappier)
Role of TLR3 in the recognition of Leishmania donovani promastigotes by IFN-g-primed macrophages
9:45 – 10:00 Sachiko Sato and I. Pelletier (Research Centre for Infectious Diseases, Laval University)
Galectin and innate immune response to Leishmania infection
10:00 – 10:15 Neeta Thawani, Mifong Tam, Mary M. Stevenson (Centre for the Study of Host Resisistance, McGill)
CpG-Induced Anemia: Mechanisms of Suppression of Erythropoiesis
0:15 – 10:30 Aws Abdul-Wahid, Peter Lee, and Gaetan Faubert (Institute of Parasitology, McGill University)
Studies on the local immune response to recombinant cyst wall protein 2 (rCWP2) in Giardia muris-infected BALB/c mice

10:30 – 11:00

Coffee, Livingston Hall Lounge,
Room L6-500

Chair: Terry Spithill

11:00 – 12:30 PM

11:00 – 12:00 Marshall Lightowlers (University of Melbourne, Australia) Vaccines against Taenia and Echinococcus: new tools to control cysticercosis and hydatid disease
12:00 – 12:15 Kimberley Grubb, Tatiana Scorza*, Marie-Claire Rioux, Terry Spithill (Institute of Parasitology, McGill; *UQ de Montreal)
Characterization of Protective ORFs from a P. c. adami DS Expression Library
12:15 – 12:30 Peter Lee and Gaetan Faubert (Institute of Parasitology, McGill)
Engineering Lactococcis lactis to express a Giardia lamblia cyst wall protein

12:30 – 2:00

Lunch and Poster Viewing,
Livingston Hall Lounge, Room L6-500

Global Health Session
Chair: Erwin Schurr

(Sponsored by the Centre for the Study of Host Resistance, McGill University and the CIHR Strategic Training Program Grant in Integrated Biology of Infectious Diseases and Autoimmunity)

2:00 – 5:30 PM

2:00 – 3:00 Alan Sher
(NIH/NIAID, Bethesda, MD)
TLR11 recognition of Toxoplasma gondii
3:00 – 3:15 Mariela Segura, Zhong Su and Mary Stevenson
Impairment of Dendritic Cell Functions by Nematode Excretory-Secretory Products: A Potential Mechanism for Immuno-suppression
3:15 – 3:30 David Gregory, Geneviève Forget and Martin Olivier
Modulation of the macrophage transcription factors STAT1α and NF- κΒ by Leishmania sp.

3:30 – 4:00

Coffee, Livingston Hall Lounge, Room L6-500

4:00 – 4:30 Philippe Gros
Genetic control of susceptibility to malaria
4:30 – 4:45 Vanessa Sancho and Danielle Malo
Candidate Gene Analysis of Ncf2 in Salmonella Susceptibility of wild-derived mice
4:45 – 5:00 Agnieszka Kielczewska and Silvia Vidal
Epistasis between mouse MHC class I and NK cell receptor loci is associated with a novel mechanism of NK cell mediated innate resistance to cytomegalovirus infection
5:00 - 5:15 Andrea Alter, A. Alcaïs, M. Giard, A. Verville, N. Van Thuc, M.O. Moraes, T. J. Hudson, L. Abel , and Erwin Schurr
High resolution linkage disequilibrium mapping of chromosomal regions linked to leprosy susceptibility
5:15 – 5:30 Serge Mostowy and Marcel Behr
Comparative genomics of the Mycobacterium tuberculosis complex

5:30 - 6:30

Terry Spithill
CHPI Student Award Presentations and Closing Reception.
Livingston Hall Lounge, Room L6-500

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