Symposium, 2004

Fourth Annual Québec Molecular Parasitology Symposium

INRS- Institut Armand-Frappier
June 21-22, 2004


Monday, June 21

9:00 - 9:15 am Welcome: Dr. Albert Descoteaux,
INRS- Institut Armand-Frappier
Dr Terry Spithill,
Director Centre for Host-Parasite Interactions

Session 1 Chair: Dr. Kris Chadee

9:15 - 9:30 Srinivas Kammanadiminti (McGill, University, K. Chadee's lab)
Immune cell signals play an important role in colonic epithelial cell responses towards Entamoeba histolytica
9:30 - 9:45 Catherine Ivory (McGill University, K. Chadee's lab)
Vaccination with Entamoeba histolytica Gal-lectin and CpG ODN induces protective immunity
9:45 - 10:45

Dr. Bill Petri

(University of Virginia, USA)
Host and Parasite Contributions to the Pathogenesis of Amebiasis

10:45 – 11:00

Coffee Break

11:00 - 11:15 Ana Pilar (McGill University, A. Jardim's lab)
The Interplay between LdPEX5 and LdPEX7 in Targeting Nascent Proteins to the Glycosome
11:15 - 11:30 Kleber P. Madrid (McGill University, A. Jardim's lab)
Analysis of the Leishmania donovani PEX5 Molecular Dynamics involved in the Import of Proteins into the Glycosome
11:30 - 11:45 Dr. Wen-Wei Zhang (McGill University, G. Matlashewski's lab)
In vivo selection for Leishmania donovani miniexon genes that increase virulence in Leishmania major
11:45 - 12:00 Dr. Anirban Ghosh (McGill University, G. Matlashewski's lab)
Developing a better adjuvant for Leishmania vaccines

12:00 - 13:30,

Lunch and Break

Session 2 Chair: Dr. Albert Descoteaux

13:30 - 14:30

Dr. Salvatore Turco

(University of Kentucky, USA)
The phosphoglycan family of Leishmania
14:30 – 14:45 Dr Robert Lodge (INRS- Institut Armand-Frappier, A. Descoteaux's lab)
Inhibition of phagosome maturation by Leishmania donovani promastigotes: regulation and impact
14:45 – 15:00 Jean-Frédéric Flandin (INRS- Institut Armand-Frappier, A. Descoteaux's lab)
Role of TLRs in the recognition of Leishmania donovani promastigotes by macrophages
15:00 - 15:30 Marianne Godbout (McGill University, M. Olivier's lab)
Role of TLRs in Leishmania-induced chemokine genes expression
15:30 - 15:45 François McNicoll (Université Laval, B. Papadopoulou's lab)
Stage-specific regulation of gene expression in the intracellular form of the parasitic protozoan Leishmania

15:45 - 16:00

Coffee Break

16:00 - 16:15 Cesar Miranda (McGill University, B. Ward's lab)
Immune modulation and the treatment of cutaneous leishmaniasis
16:15 – 16:45 Dr. Zhong Su (McGill University, M. Stevenson's lab)
Modulation of protective immunity against blood-stage malaria by concurrent nematode infection
16:45 – 17:00 Dr. Lena Serghides (University of Toronto, K. Kain's lab)
Chondroitin-sulphate-A binding malaria parasites evade non-opsonic phagocytic clearance: A potential contributor to malaria-associated morbidity during pregnancy
17:00 - 17:15 Samir Patel (University of Toronto, K. Kain's lab) Clearance of Plasmodium chabaudi chabaudi AS infection in mice is mediated by a CD36-dependent mechanism
17:15 - 17:30 Julie Baillargeon (Université de Montréal, G. Fecteau's lab)
Study on the contamination of bovine colostrum by Cryptosporidium parvum oocysts

17:30 - 21:00

Drinks, Buffet Dinner, Poster session

Tuesday June 22

Session 3 Chair: Dr. Marc Ouellette

9:00 - 9:15 Benjamin Gourbal (Université Laval, M. Ouellette's lab)
Functional cloning and isolation of the trivalent antimony importer in Leishmania
9:15 - 9:30 Dr. Marc Ouellette (Université Laval)
Novel aspects on folate transport and metabolism in Leishmania
9:30 - 10:30

Dr. Tom Seebeck

(University of Bern, Switzerland)
Cyclic AMP signalling in trypanosomatids

10:30 – 10:45

Coffee Break

10:45 - 11:00 Guillaume Chatain (McGill University, S. Bohle's lab)
Coupled or uncoupled heme processing and hemoglobing digestion in P. falciparum?
11:00- 11:15

Dr Michael Grigg

(University of British Columbia, BC)
Sex and living by the 'wild' clades of Toxoplasma: the Sea Otter story
11:15 - 11:30 J. Nabhan (McGill University, P. Ribeiro's lab)
A structural/functional analysis of an essential proteasome subunit, RPN11, in Schistosoma mansoni and human cells
11:30 - 11:45 F. El-Shahabi (McGill University, P. Ribeiro's lab)
Characterization of a histamine-responsive receptor (SmGPCR) in Schistosoma mansoni
11:45 - 13:45 Shufeng Zhou (McGill University, Robin Beech's lab)
The Role of the HG1 and HcGluCla genes on larval movement of H. contortus

12:00 - 13:30

Lunch and Break

13:00 - 13:30

Trainees Meeting:

Designation of a student/postdoc representative on theCHPI Steering Committee

Session 4 Chair: Dr. Roger Prichard

13:45 - 14:45

Dr. John Gilleard

(University of Glasgow, UK)
Functional genomics in parasitic nematodes: Distant dream or imminent reality?
14:45 – 15:15 Dr. Joe Dent (McGill University)
The Genetics of Ivermectin Sensitivity in C. elegans

14:45 – 15:00

Coffee Break

15:00 - 15:30 Catherine Bourguinat (McGill University, R. Prichard's lab)
Ivermectin selection on beta-tubulin in Onchocerca volvulus
15:30 - 15:45 Dr. Alain Roulet (McGill University, R. Prichard's lab)
Expression analysis of six P-glycoproteins between macrocyclic lactones sensitive and resistant H. contortus strains
15:45 - 16:00 Dr. Adam Rainczuk (McGill University, B. Ward's lab)
SELDI ToF MS and protozoa: novel diagnostic approach & insights into parasite biology
16:00 - 16:30

Dr. Terry Spithill,

Director, Institute of Parasitology

Closing ceremony and remarks

Poster session Monday evening June 21

  1. Issa Abu Dayyeh (McGill University)
    Modulation of host phosphotyrosine phosphatases by Leishmania donovani infantum promastigotes and amastigotes
  2. Maria Adelaida Gomez (McGill University)
    Leishmania-induced macrophage phosphotyrosine phosphatases: Role of metal in PTPs activities regulation
  3. Mariela Segura, Zhong Su, and Mary M. Stevenson (McGill University)
    Nematode excretory-secretory products impair the maturation and cytokine production of bone marrow-derived dendritic cells
  4. Rebecca Ing and Mary M. Stevenson (McGill University)
    Dendritic cells interact with NK cells to promote Th1 immune responses to blood-stage malaria infection.
  5. Indranil Dey, Kathy Keller, Scott Bhole and Kris Chadee (McGill University)
    Molecular characterization of a Cox-like enzyme from Entamoeba histolytica
  6. Celia Caballero, Karen Madsen and Kris Chadee (McGill University)
    Probiotics secreted products stimulate mucin secretion from colonic epithelial cells
  7. Darcy Moncada, Kathy Keller and Kris Chadee (McGill University)
    Degradation of the N- and C-terminal domains of colonic mucin by Entamoeba histolytica cysteine proteases
  8. Isabelle Pelletier (Université Laval)
    Seeing strangers or announcing "danger": Roles of galectins in innate immune responses in leishmaniasis
  9. Patocka, K. Bangs and P. Ribeiro (McGill University)
    Cloning and RNA interference studies of a serotonin transporter (SERT) in Schistosoma mansoni
  10. S. Dernovitch and P. Ribeiro (McGill University)
    Properties of a serotonin 5HT2 receptor in Caenarnabditis elegans: Knockout studies
  11. Anne Schwab, Roger Prichard (McGill University)
    Examination of SNPs associated with anthelmintic resistance in the filarial parasite, Wuchereria bancrofti
  12. Annie-Claude Bourgeois, Kris Koski, Tao Tu and Marilyn Scott (McGill University)
    Impact of boron deficiency and boron excess on gastrointestinal nematodes
  13. Leslie Payne, Marilyn Scott, Eduardo Ortega & Kris Koski (McGill University)
    Ascaris Infection and Re-Infection Rates in Vitamin-A Supplemented and Unsupplemented Panamanian Children
  14. Cristina Gheorghiu and Marilyn Scott (McGill University)
    Impact of Waterborne Zinc on Gyrodactylus (Mongenea) Infections on the Skin of Guppies
  15. Tao Tu, Marilyn Scott and Kris Koski (McGill University)
    Protein refeeding rapidly restores functional protection against Heligmosomoides polygyrus (Nematoda)
  16. Gundula Min-Oo, Anny Fortin, Mifong Tam, Mary M. Stevenson, and Philippe Gros (McGill University)
    Identification of an additional minor locus controlling resistance to malaria in the AcB55 recombinant congenic mouse strain.
  17. Karima El Fadili, Nadine Messier, Chantal Guimond, Nathalie Trudel, Gaétan Roy, Danielle Légaré, and Marc Ouellette (Université Laval)
    Role of the ABC transporter PGPA in antimony resistance in Leishmania infantum amastigotes.
  18. Hamid Mahmoudzadeh-niknam (Université Laval)
    Leishmania tropica induces partial protection against Leishmania major in BALB/c mice
  19. Maxime Laverdière (Université Laval)
    The effect of stress on global mRNA translation in Leishmania
  20. Annie Rochette (Université Laval)
    Structural characterization and expression analysis of the developmentally regulated amastin gene family in Leishmania spp.
  21. Conan Chow (Université Laval)
    Characterization of translation initiation factors in Leishmania
  22. Fabio Vasquez, Terry Spithill, Claribel Garcia-Socarras, Brian Ward, Momar Ndao (McGill University)
    Fasciola diagnostics: comparison of 'gold standard' EIA to recombinant cathepsin D assay
  23. Milli Nath-Chowdhoury, Momar Ndao, James McKerrow, Michael Arrowood, Brian Ward (McGill University)
    Protease inhibitors for C. parvum infection
  24. Natalie Clairoux, Momar Ndao, Brian Ward and Terry Spithill (McGill University)
    Detection of biomarkers associated with Fasciola infection in sheep using the SELDI ProteinChip® Mass Spectrometry
  25. Cynthia Santamaria, Robin Beech and Terry Spithill (McGill University)
    Mining the Plasmodium falciparum genome for new merozoite surface proteins
  26. Tatiana Scorza, Kimberley Grubb, Peter Smooker, David Proll and Terry Spithill (McGill University)
    Induction of strain-transcending immunity against Plasmodium chabaudi malaria with a multiepitope DNA vaccine
  27. Rya Boscariol, Jill Pleasance, David Piedrafita, Herman Raadsma, Tatiana Scorza and Terry Spithill (McGill University)
    Characterisation of two alleles of ovine CD4 sequence
  28. Modulation of Protein Tyrosine Phosphatase Activity in RAW 264.7 Macrophages Expressing the Nramp-1 Gene: Implications in Host Resistance to Leishmania donovani infection
  29. Silvana Jananji and Albert Descoteaux (INRS- Institut Armand-Frappier)
    Role of phosphatidylinositol 3-kinase in the phagocytosis of Leishmania donovani promastigotes by RAW 264.7 macrophages
  30. Aaron Kosar (McGill University, S. Bohle's lab)
    New soluble models for the chloroquine drug target in malaria
  31. Aurelie Girard, Aws Abdul-Wahid, and Gaetan Faubert (McGill University) Mucosal immune responses stimulated by gene gun administration of DNA transmission blocking vaccine expressing PRO CWP2 of Giardia duodenalis.
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