Janet Yee

Assistant Professor

ext. 7048/7148
Fax: 705-748-1625
Email: jyee [at] trentu.ca
Lab website: www.jyee.ca

Research interests

Molecular Biology
Biochemistry

The protozoan parasite, Giardia lamblia, is responsible for "beaver fever," the most common form of infectious diarrhea in humans, domestic animals, and wildlife. This organism is found in freshwater lakes and streams worldwide, and ingestion of contaminated water by the host initiates the infection cycle. Our laboratory is involved in the molecular and biochemical study of this waterborne parasite. Our current research is to study the changes in gene expression throughout the Giardia cell cycle, and the regulation of the core histone genes. Techniques utilized in my laboratory include gene cloning, cell transfections, luciferase assays, gel mobility shift assays, real-time PCR, microarray, and column chromatography.

Selected publications

Roy SW, Hudson AJ, Joseph J, Yee J, Russell AG.

Lustig DB, Kempt C, Alam S, Clancy J, Yee J, Rafferty SP.
Mutation of conserved tryptophan residues at the dimer interface of Staphylococcus aureus nitric oxide synthase. Arch Biochem Biophys. 2011 Feb 15;506(2):165-72. Epub 2010 Dec 11.

Boyd AL, Salleh A, Humber B, Yee J, Tomes L, Kerr LR.
Neonatal experiences differentially influence mammary gland morphology, estrogen receptor {α} protein levels, and carcinogenesis in BALB/c mice. Cancer Prev Res (Phila). 2010 Nov;3(11):1398-408. Epub 2010 Nov 7.

Achá D, Hintelmann H, Yee J.
Importance of sulfate reducing bacteria in mercury methylation and demethylation in periphyton from Bolivian Amazon region. Chemosphere. 2011 Feb;82(6):911-6. Epub 2010 Nov 11.

Woodcroft MW, Ellis DA, Rafferty SP, Burns DC, March RE, Stock NL, Trumpour KS, Yee J, Munro K.
Experimental characterization of the mechanism of perfluorocarboxylic acids' liver protein bioaccumulation: the key role of the neutral species. Environ Toxicol Chem. 2010 Aug;29(8):1669-77.

Rafferty S, Luu B, March RE, Yee J.
Giardia lamblia encodes a functional flavohemoglobin. Biochem Biophys Res Commun. 2010 Aug 27;399(3):347-51. Epub 2010 Jul 22.

Yee J, Tang A, Lau WL, Ritter H, Delport D, Page M, Adam RD, Müller M, Wu G.
Core histone genes of Giardia intestinalis: genomic organization, promoter structure, and expression. BMC Mol Biol. 2007 Apr 10;8:26.

Beaudette PC, Chlup M, Yee J, Emery RJ.
Relationships of root conductivity and aquaporin gene expression in Pisum sativum: diurnal patterns and the response to HgCl2 and ABA. J Exp Bot. 2007;58(6):1291-300. Epub 2007 Mar 7.

Publications - Janet Yee

 

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