Head of Parasitology Laboratory
Institut national de santé publique du Québec (INSPQ) - Laboratoire de santé publique du Québec (LSPQ) [Québec Public Health Laboratory]
20045 Chemin Sainte-Marie
Sainte-Anne-de-Bellevue, QC, Canada, H9X 3R5
Email: karine.thivierge [at] inspq.qc.ca
The Parasitology Laboratory is part of the LSPQ, which acts as the provincial reference laboratory in microbiology and quality assurance. The laboratory offers a wide range of analytical services for the detection and identification of enteric parasites and medically important arthropods. It is also in charge of the provincial blacklegged tick and Lyme disease surveillance program. As a center of excellence in parasitology, it provides several training programs in the diagnostic of intestinal and blood parasites to healthcare professionals.
In line with the mission of the Parasitology Laboratory, my research interests focus on the development of new molecular-based diagnostic tests for detection of intestinal parasites and on surveillance of emerging vector-borne diseases. As part of my function as scientific advisor on the Groupe scientifique sur l’eau of the Institut national de santé publique du Québec, I also have a strong interest in waterborne parasitic diseases such as Cryptosporidiosis and giardiasis. Prior to this position, my research activities were centered on the understanding of the biology and biochemistry of helminth parasites (Schistosoma mansoni and Fasciola hepatica), and on the interplay between parasites and their hosts.
Keywords: intestinal parasites, Giardia lamblia, Cryptosporidium sp., Entamoeba histolytica, Lyme disease, Ixodes scapularis, emerging vector-borne diseases, microsporidia, Babesia microti
Thivierge, K., Cotton, S., Schaefer, D., Riggs, M. W., To, J., Lund, M. E., Robinson, M. W., Dalton, J. P., Donnelly, S. 2013. Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of cytotoxic, antimicrobial and anti-protozoan activities imply a specific adaptation to immune modulation. PLOSNTD 7, e2307.
Cotton, S., Donnelly, S., Robinson, M. W., Dalton, J. P., Thivierge, K. 2012. Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules? Front Immunol. 3, 1-7.
Thivierge, K., Mathews, R. T., Nsangou, D. M. M., Da Silva, F., Cotton, S., Skinner-Adams, T. S., Trenholme, K. R., Brown, C., L., Gardiner, D. L., Dalton, J. P. 2012. Anti-malaria drug development targeting the M1 alanyl aminopeptidases and M17 leucyl aminopeptidases. ARKIVOC 4, 330-346.
Nanguo, D. M. M., Thivierge, K., Mathews, R., Gardiner, D., Dalton, J. P. Malaria M17 Leucine Aminopeptidase. 2012. The Handbook of Proteolytic Enzymes (eds. Neil D. Rawlings and Guy Salvesen) Elsevier Ltd, Oxford, UK, 4094 p.
Skinner-Adams, T., Peatey, C., Anderson, K., Trenholme, K., Krige, D., Brown, C., Stack, C., Nsangou, D., Mathews, R., Thivierge, K., Dalton, J. P., Gardiner, D. 2012. The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria. Antimicrob. Agents Chemother. 56, 3244-3249.
Thivierge, K., Prado, A., Driscoll, B. T., Bonneil, E., Thibault, P., Bede, J. 2010. Caterpillar- and salivary-specific modification of plant proteins. J. Proteome Res. 9, 5887-5895.
Cotton, S., Grangeon, R., Thivierge, K., Mathieu, I., Ide, C., Weit, T., Wang, A., Laliberté, J.-F. 2009. Turnip mosaic virus RNA replication complex vesicles are mobile, align with microfilaments and are each derived from a single viral genome. J. Virol. 83, 10460-10471.
Thivierge, K., Cotton, S., Dufresne, P. J., Mathieu, I., Beauchemin, C., Ide, C., Fortin, M. G., Laliberté, J.-F. 2008. Eukaryotic elongation factor 1A interacts with Turnip mosaic virus RNA-dependent RNA polymerase and VPg-Pro in virus-induced vesicles. Virology 377, 216-225.
Dufresne, P. J., Thivierge, K., Cotton, S., Beauchemin, C., Ide, C., Ubalijoro, E., Fortin, M. G., Laliberté, J.-F. 2008. Heat shock 70 protein interaction with Turnip mosaic virus RNA-dependent RNA polymerase within virus-induced membrane vesicles. Virology 374, 217-227.
Cotton, S., Dufresne, P. J., Thivierge, K., Fortin, M. G. 2006. The VPgPro protein of Turnip mosaic virus: In vitro inhibition of translation from a ribonuclease activity. Virology 351, 92-100.
Thivierge, K., Nicaise, V., Dufresne, P. J., Cotton, S., Laliberté, J.-F., Le Gall, O., Fortin, M. G. 2005. Plant virus RNAs: Coordinated recruitment of conserved host functions by (+) ssRNA viruses during early infection events. Plant Physiol. 138, 1822-1827.