Terry Spithill

Professor and Director
E: T.Spithill [at] latrobe.edu.au

Research Interests


- Identify and characterize surface-exposed tegument proteins expressed in F hepatica and recognised by sera from vaccinated cattle
- Population genetics of triclabendazole resistance in liver fluke parasites


Selected Publications

Norbury LJ, Hung A, Beckham S, Pike RN, Spithill TW, Craik CS, Choe Y, Fecondo JV, Smooker PM.
Analysis of Fasciola cathepsin L5 by S(2) subsite substitutions and determination of the P(1)-P(4) specificity reveals an unusual preference. Biochimie. 2012 Jan 20. [Epub ahead of print]

Wilson RA, Wright JM, de Castro-Borges W, Parker-Manuel SJ, Dowle AA, Ashton PD, Young ND, Gasser RB, Spithill TW.
Exploring the Fasciola hepatica tegument proteome. Int J Parasitol. 2011 Nov;41(13-14):1347-59. Epub 2011 Oct 5.

Young ND, Jex AR, Cantacessi C, Hall RS, Campbell BE, Spithill TW, Tangkawattana S, Tangkawattana P, Laha T, Gasser RB.
A portrait of the transcriptome of the neglected trematode, Fasciola gigantica--biological and biotechnological implications. PLoS Negl Trop Dis. 2011 Feb 1;5(2):e1004.

Norbury LJ, Beckham S, Pike RN, Grams R, Spithill TW, Fecondo JV, Smooker PM.
Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles. Biochimie. 2011 Mar;93(3):604-11. Epub 2010 Dec 16.

Ndao M, Rainczuk A, Rioux MC, Spithill TW, Ward BJ.
Is SELDI-TOF a valid tool for diagnostic biomarkers? Trends Parasitol. 2010 Dec;26(12):561-7. Epub 2010 Aug 12.

Piedrafita D, Spithill TW, Smith RE, Raadsma HW.
Improving animal and human health through understanding liver fluke immunology. Parasite Immunol. 2010 Aug;32(8):572-81. Review.

 Smooker PM, Jayaraj R, Pike RN, Spithill TW.
Cathepsin B proteases of flukes: the key to facilitating parasite control? Trends Parasitol. 2010 Oct;26(10):506-14. Epub 2010 Jun 30. Review.

Publications - Terry Spithill

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