Derek M. McKay

Professor


Department of Physiology and Pharmacology

   
Lab: (403) 210-8999   
Fax:  (403) 210-8119
dmckay [at] ucalgary.ca (Email)

 

Research

 

  •  Immune interactions in the regulation of intestinal physiology (e.g. epithelial function).  Use of animal models and cell culture to determine if, and then how immune cells (i.e. T cells or monocytes/macrophages) and immune mediators affect epithelial function, particularly active ion transport, barrier properties and cytokine/chemokine production.
  • Analysis of direct signal transduction events mobilized in  human gut epithelia in response to cytokines, principally interferon-γ(IFNγ) and transforming a growth factor-β (TGFβ) and how the mobilized pathways cross talk to regulate epithelial function.
  • Assessment of the impact of pathogenic and non-pathogenic (i.e. commensal or non-noxious) bacteria and bacterial products (e.g. superantigens, CpG-rich DNA) on epithelial physiology, and the role of these agents in modifying gut form and function in rodents.
  • Use of animal models of colitis to examine neuronal control of epithelial ion transport.
  • Parasitisms as models of gut dysfunction.  Examination of how the tapeworm, Hymenolepis diminuta, can prevent or treat a chemically-induced colitis in non-permissive hosts (i.e. helminth is spontaneously expelled) and the permissive rat host where the worm establishes and lives to maturity.

 

Publications - Derek M. McKay