Kris Chadee


Microbiology and Infectious Diseases
CRC Chair in Gastrointestinal Inflammation

University of Calgary
Health Research Innovation Centre
3330 Hospital Drive NW
Calgary Alberta T2N 4N1 CANADA 

Tel.: 403-210-3975
Fax: 403-270-2772
kchadee [at] (Email)

Research interests

Mucosal immunology: biochemical and molecular interactions of colonic mucins in host defense against intestinal protozoan parasites; cell-mediated immune dysfunction and regulatory mechanisms in Entamoeba histolytica infections; immunoregulation of macrophage inflammatory and effector functions.

Selected Publications

Allen-Vercoe E, Strauss J, Chadee K.
Fusobacterium nucleatum: An emerging gut pathogen? Gut Microbes. 2011 Sep 1;2(5). [Epub ahead of print]

Dharmani P, Leung P, Chadee K.
Tumor necrosis factor-α and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. PLoS One. 2011;6(9):e25058. Epub 2011 Sep 19.

Lejeune M, Moreau F, Chadee K.
Prostaglandin E2 produced by Entamoeba histolytica signals via EP4 receptor and alters claudin-4 to increase ion permeability of tight junctions. Am J Pathol. 2011 Aug;179(2):807-18. Epub 2011 May 31.

Kissoon-Singh V, Mortimer L, Chadee K.
Entamoeba histolytica cathepsin-like enzymes : interactions with the host gut. Adv Exp Med Biol. 2011;712:62-83. Review.

Dharmani P, Strauss J, Ambrose C, Allen-Vercoe E, Chadee K.
Fusobacterium nucleatum infection of colonic cells stimulates MUC2 mucin and tumor necrosis factor alpha. Infect Immun. 2011 Jul;79(7):2597-607. Epub 2011 May 2.

Wallace JL, Vong L, Dharmani P, Srivastava V, Chadee K.
Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair. Am J Pathol. 2011 Mar;178(3):1126-33.

Lourenssen S, Houpt ER, Chadee K, Blennerhassett MG.
Entamoeba histolytica infection and secreted proteins proteolytically damage enteric neurons. Infect Immun. 2010 Dec;78(12):5332-40. Epub 2010 Sep 20.

Publications - Kris Chadee

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