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UID:20260404T034844EDT-50753japtU@132.216.98.100
DTSTAMP:20260404T074844Z
DESCRIPTION:Abstract:\n\nPhenols are important components of animal\, plant
  and fungal tissues\, where they perform a variety of biological functions
  including bioadhesion\, pigmentation\, chemical defense\, redox and antio
 xidant properties. One of the most important classes of phenols are catech
 ols (ortho-dihydroxyphenyls)\, whose occurrence in humans is largely limit
 ed to dopamine and related neurotransmitters\, and 3\,4-dihydroxy-L-alanin
 e (DOPA)\, the main building block of melanin. Although catechols are rare
 ly found in structural proteins in mammals\, they are key components of st
 ructural tissues in some marine invertebrates. Celebrated examples are the
  proteins of the byssus\, the attachment organ of the mussel. Several byss
 al proteins contain high levels of DOPA\, which is believed to contribute 
 to both the interfacial and bulk mechanical performance of the tissue. Ful
 filling such diverse roles is possible because catechols participate in a 
 remarkably broad and complex range of chemical interactions that include n
 oncovalent coordination interactions with metals/metal oxides\, strong hyd
 rogen bond\, cation-pi and pi-pi interactions\, redox activity\, and coval
 ent coupling with nucleophilic organic species.\n\nIn the first part of th
 is talk I will review the many functions of catechols in the mussel byssus
 \, including results of ongoing studies aimed at shedding new light on the
  molecular mechanics of DOPA at solid-liquid interfaces. In the second par
 t of the talk I will provide a few selected examples of how we seek to exp
 loit catechols as building blocks of synthetic bioinspired adhesives\, hyd
 rogels and coatings. Finally\, I will conclude with a few comments on plan
 t polyphenols\, which are biologically sourced\, renewable\, and have simi
 lar physicochemical properties that make them attractive as building block
 s for functional materials.\n\nBio:\n\nPhillip B. Messersmith is the Class
  of 1941 Professor in the Departments of Bioengineering and Materials Scie
 nce and Engineering at UC-Berkeley. He earned his B.S. degree in life scie
 nces from the University of Illinois at Urbana\, M.S degree in bioengineer
 ing from Clemson University\, and his Ph.D. degree in materials science an
 d engineering from the University of Illinois at Urbana. Previously\, Dr. 
 Messersmith was a postdoctoral fellow at Cornell University (1993-1994)\, 
 and a faculty member at the University of Illinois at Chicago (1994-1997) 
 and Northwestern University (1997-2014). Dr. Messersmith has published ove
 r 200 papers and has 43 patents. His awards and honors include a MERIT awa
 rd from the National Institutes of Health\, the Langmuir Lecture Award fro
 m the American Chemical Society\, and the 2013 Clemson Award for Basic Res
 earch from the Society for Biomaterials. Dr. Messersmith is a fellow of th
 e American Institute for Medical and Biological Engineering\, the Royal So
 ciety of Chemistry\, and the International Union of Societies of Biomateri
 als Science and Engineering. The Messersmith research group is interested 
 in understanding structure-processing-property relationships of materials 
 in biological systems\, and in using this information to inform the design
  and synthesis of biologically inspired synthetic materials for a variety 
 of practical applications.\n
DTSTART:20200114T180000Z
DTEND:20200114T193000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:The 2020 Clifford B. Purves Lecture: Phil Messersmith -
URL:https://www.mcgill.ca/chemistry/channels/event/2020-clifford-b-purves-l
 ecture-phil-messersmith-303017
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