Scientists demonstrate flaws in protein detection tools, and outline a solution

A new study points to the need for better antibody validation, and outlines a process that other labs can use to make sure the antibodies they work with function properly.

Antibodies are used in laboratories and clinics to study proteins, which are the biomolecules that translate information from an organism’s genes into the structure, function, and regulation of its tissues and organs. Genetic mutations can cause protein imbalances or malfunctions, leading to human disease.

Classified as: ALS, Peter McPherson, antibodies, proteins, genetics, reproducibility, amyotrophic lateral sclerosis, genes
Published on: 15 Oct 2019

Cancer scientists overestimate the extent to which high-profile preclinical studies can be successfully replicated, new research from McGill University suggests.

Classified as: reproducibility, preclinical studies, Cancer, Reproducibility Project: Cancer Biology, Jonathan Kimmelman
Published on: 29 Jun 2017

Badly designed studies may lead to the efficacy of drugs being overestimated and money being wasted on trials that prove fruitless, according to a new study from McGill University in Canada.

Classified as: Research, animal research, mice, Clinical trials, drug trial, sunitinib, preclinical research, animal study, animal models, cancer drug, randomization, blinding, Jonathan Kimmelman, reproducibility, study design, guinea pig
Published on: 14 Oct 2015
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