Since its earliest days, vaccination has been attended by hesitation, resistance and controversy. Why did an innovation that promised to rid the world of the terrible scourge of smallpox inspire such enduring fear? When Jenner spearheaded the promotion of vaccination at the turn of the nineteenth century, he predicted the end of a disease that had taken 60 million lives in the eighteenth century alone. He was right, but it took until 1980 before the World Health Organization could proclaim “smallpox zero”.
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