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DESCRIPTION:Title: Doubly-Robust Bayesian Estimation of Individualized Trea
 tment Rules Using Network Meta-Analysis.\n\nAbstract\n\n \n\nAn optimal In
 dividualized Treatment Rule (ITR) is a function that takes a patient's cha
 racteristics\, such as demographics\, biomarkers\, and treatment history\,
  and outputs a treatment that is expected to give the best outcome for tha
 t patient. When estimating ITRs from individual studies\, power to detect 
 important treatment-covariate interactions is often low. Additionally\, al
 l treatments of interest may not be compared head-to-head in a single stud
 y. Network Meta-Analysis (NMA) is a method of synthesizing data from multi
 ple studies to estimate the relative effects of a set of treatments. Two-s
 tage ITR NMA is an emerging technique for the estimation of ITRs that can 
 improve power and simultaneously consider all relevant treatment options w
 hile protecting sensitive data. In the first stage\, study-specific ITRs a
 re estimated\, and in the second stage\, the study-specific ITRs are poole
 d using an NMA model. In this talk\, we propose a doubly-robust and fully 
 Bayesian approach to estimating study-level ITRs. We also show how missing
 -at-random outcomes can be accounted for in this approach. We then propose
  a Bayesian NMA model for pooling the study-level ITRs that leverages the 
 full covariance matrix of the estimates. Finally\, we use the methods to e
 stimate an optimal ITR for major depressive disorder using data from three
  adaptive trials.\n\n \n\nSpeaker bio\n\n \n\nAugustine Wigle currently ho
 lds an NSERC Postdoctoral Fellowship at McGill University supervised by Pr
 of. Erica Moodie in the Department of Epidemiology\, Biostatistics and Occ
 upational Health. She is interested in Bayesian methods\, network meta-ana
 lysis\, and precision medicine. For more information\, please visit:\n\nht
 tps://sites.google.com/view/augustinewigle\n
DTSTART:20260114T203000Z
DTEND:20260114T213000Z
LOCATION:Room 1140\, McGill College 2001\, CA\, QC\, Montreal\, H3A 1G1\, 2
 001\, avenue McGill College
SUMMARY:Augustine Wigle (McGill )
URL:https://www.mcgill.ca/channels/channels/event/augustine-wigle-mcgill-37
 0232
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