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DESCRIPTION:JOINT CORE/EBOH EPI Seminar Series Fall 2025\n\nThe Seminars in
  Epidemiology organized by the Department of Epidemiology\, Biostatistics 
 and Occupational Health at the McGill School of Population and Global Heal
 th is a self-approved Group Learning Activity (Section 1) as defined by th
 e maintenance of certification program of the Royal College of Physicians 
 and Surgeons of Canada. Physicians requiring accreditation\, please comple
 te the Evaluation Form and send to admincoord.eboh [at] mcgill.ca.\n\nDr. 
 Karen Brown\n\nProfessor of Medicine\n	Dept of Anesthesia\, Div of Pediatri
 c Anesthesia\n	Montreal Children's Hospital | McGill University Health Cent
 er\n\nWHEN: Monday\, November 24\, 2025\, from 3:30-4:30pm\n	WHERE: Hybrid 
 | 2001 McGill College\, Rm 1140 &\n	Onsite at 5252 boul. de Maisonneuve - 3
 rd floor\, 3B Kitchen | Zoom\n	Note: Karen Brown will be presenting in-pers
 on at CORE\n\nAbstract\n\nObstructive sleep-disordered breathing (oSDB) is
  pro-inflammatory and thus may modulate pain. We conducted a prospective c
 ohort study of children (2-12y) undergoing adenotonsillectomy. EXPOSURE va
 riable (severity of oSDB) = STBUR questionnaire score. OUTCOME variable(s)
  Parents’ Postoperative Pain Measure for 14 postoperative days (PODs). Res
 ults Complete PPPM data (2\,480 scores) for 10 PODs were recorded from 124
 /245 (51%) patients. Imputed values were derived for 941 missing PPPM scor
 es. Group-based trajectory models identified 3 pain trajectory groups. Chi
 ldren with higher mSTBUR scores were significantly less likely to be in th
 e low or moderate pain trajectory groups. When compared with Trajectory1\,
  children in Trajectory2 and Trajectory3 had respectively\, 4-fold and 11-
 fold higher odds for unscheduled revisits to hospital.\n\nSpeaker Bio\n\nD
 r Brown graduated Medicine at the University of Toronto. In 1990 she was r
 ecruited to Montreal Children’s Hospital Department of Pediatric Anesthesi
 a. Sleep apnea was emerging as a major indication for tonsillectomy in chi
 ldren and in collaboration with the MCH sleep lab\, directed by Dr Robert 
 Brouillette\, she published several papers on perioperative respiratory co
 mplications following tonsillectomy.\n\nIn collaboration with Dr Immanuell
 a Moss\, Respiratory Medicine\, she reported a heightened respiratory opio
 id sensitivity in children with severe recurrent nocturnal hypoxemia.\n\nI
 n 2017\, following reports of important post-tonsillectomy pain Dr Brown a
 nd colleagues conducted a prospective study asking parents to report their
  experience at home. The analysis of these data led to a collaboration wit
 h the BCU and is the subject of this talk.\n\nLearning Objectives\n\nAt th
 e completion of this talk\, attendees will be able to:\n\n\n	Describe the c
 hallenges presented by Real-World data obtained from the home environment\
 ;\n	Discuss our analysis Methods: Missingness\, MICE & the Fitting of Traje
 ctory Models\;\n	Discuss the evaluation of the performance of this analysis
  and the interpretation of our results\;\n	Highlight the challenges of publ
 ishing in clinical journals.\n\n
DTSTART:20251124T203000Z
DTEND:20251124T213000Z
SUMMARY:A Trajectory Analysis of Pain Following Tonsillectomy
URL:https://www.mcgill.ca/channels/channels/event/trajectory-analysis-pain-
 following-tonsillectomy-368895
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