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DTSTAMP:20260406T044410Z
DESCRIPTION:Peripheral nerve injury leads to long-lasting pain hypersensiti
 vity. Damaged primary afferents release chemokines\, signaling molecules\,
  and proteases to activate spinal cord microglia\, which in turn\, enhance
  the excitability of spinal nociceptive circuits. Microglia release an arr
 ay of bioactive substances that bind to cell surface receptors to increase
  neuronal activity via modulation of intracellular processes. However\, ho
 w these substances specifically sensitize pain-processing circuits without
  affecting other modalities\, including itch and proprioception\, is not w
 ell understood. Studies of mechanisms by which microglia affect neuronal f
 unctions in the spinal cord have focused on intracellular mechanisms of ac
 tion rather than modulation of the extracellular matrix. The extracellular
  matrix in the central nervous system (CNS) not only provides structural s
 upport but is also involved in the regulation of neuronal excitability and
  synaptic plasticity. Perineuronal nets (PNNs) are the most prominent extr
 acellular matrix structures in the CNS\, composed of a proteoglycan core p
 rotein decorated by chondroitin sulfate sugar chains. In this talk\, I wil
 l present evidence showing that PNNs are found around and affect the activ
 ity of spinal cord neurons involved in the processing of nociceptive infor
 mation. I will also describe studies demonstrating the heterogeneity of sp
 inal cord microglia\, which exhibit time- and sex-specific transcriptional
  responses to peripheral nerve injury.\n\nThis seminar will take place bot
 h in-person and online. Details in attached poster\n
DTSTART:20230224T160000Z
DTEND:20230224T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: New roles of microglia and extracellular matrix
  in pain
URL:https://www.mcgill.ca/channels/channels/event/physiology-seminar-new-ro
 les-microglia-and-extracellular-matrix-pain-345997
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