McGill Centre for Bioinformatics presents Dr. Henri Orland, "Dominant Pathways in Protein Folding"

Protein folding can be described by the Langevin dynamics. This dynamics can in turn  be represented by a “path integral”, which is a weighted sum over all paths joining the denatured state with the native state of the protein. We show how one can compute the dominant paths (paths with largest weight) and how one can calculate dynamical quantities such as rates or transition path times from these paths. The method is illustrated on various simple examples.