Dr. Nathan Siemers, Dissecting Kinase Inhibitor Activities by Genome-Wide Dose Response Analysis

Dose response curves are a standard way to measure the effect of drug treatment.  I'll describe methods to implement this methodology to measure drug activities genome-wide via transcriptional profiling tools and appropriately designed experiments.  Several new analytical methods as well as visualization tools have been devised to address the computational challenges and assist with interpretation of results.  The methods offer potential advantages in terms of characterizing candidate drugs and dissecting poly-pharmacology in areas of drug development such as kinase inhibitor research, where design of selective compounds can be highly challenging.