Biochemistry Seminar Dr. Daniel Figeys

Dr. Daniel Figeys
Director, The Ottawa Institute of Systems Biology
Canada Research Chair in Proteomics and Systems Biology
Professor of Biochemistry, BMI Department, Faculty of Medicine, University of Ottawa

“Proteomics and lipidomics of human diseases ”

We are interested in using proteomics and lipidomics to better understand biological processes associated with diseases, in particular neurodegenerative and cardiovascular diseases.  These diseases pose some interesting technical challenges.  For example, the amount of sample is a limiting factor when studying specific regions of the brain.  Although, proteomics can routinely identify and quantify 1000’s of proteins, this is generally done using  a large amount of material.  Here, we will present technologies to study minute amounts of specific regions of the brain using proteomics and lipidomics.  We are also studying the role of the regulation of LDL and VLDL in liver cells.  This requires studying biological processes from the ER, Golgi, endosome, and plasma membrane.  We will present some of our approach to study the proteome and the lipidome at the sub-cellular level.