Orlowski Lab publishes paper in Nature Communications


Published: 9Jun2021

Congrats to the Orlowski Lab on their recent paper published in Nature Communications entitled "Structure and mechanism of the human NHE1-CHP1 complex."

The paper was done in collaboration with a structural research group in China headed by Dr. Yan Zhao on the cryo-electron microscopy (cryo-EM) structure of the Human Na+/H+ exchanger NHE1 isoform in a complex with one of its interacting partners, the calcineurin B-homologous protein 1 (CHP1). This is the first high resolution structure of a human Na+/H+ exchanger, an ion transporter the Orlowski Lab has been studying for the last 30 years. Great work, team!

To access the paper online, follow this link: https://rdcu.be/cmdba

Photo (above): Members of the Orlowski Lab - Dr. John Orlowski, Annie Boucher and Alina Ilie. Dr. DuSik Kim from Dr. Hanahan’s lab also contributed to this study (image not available).

Photo (right): Co-senior author/collaborator - Dr. Yan Zhao from the National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academic Sciences, Beijing, China

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