Biocompatible and toughened multilayered bone graft
A new type of bone graft for the treatment of large bone defects has been developed at McGill University.
Typical bone graft materials have been primarily effective for non-structural bony defects or extremely small and simple segmental defects. This is because the common reinforcing materials are strong, but not sufficiently resistant to catastrophic failure through cracking. This can be partially fixed by implanting composite matrixes, although they are designed to be temporary place fillers for regrowth of bone voids.
The invention is a new type of toughened, multilayered bone graft made of calcium phosphates and collagen/gelatin interfaces for the treatment of larger segmental bone defects or defects that have a complex geometry. The ingredients are biocompatible/biodegradable in the human body, and all are FDA-approved. The multilayered structure of the material gives high strength and toughness, so the implant can carry mechanical loads once in place. Moreover, the layer-by-layer fabrication enables implants of complex, patient-specific, 3D shapes.
- Multilayered bone grafts for the treatment of large segmental bone defects with a complex geometry
- Ingredients are biocompatible and FDA-approved
- Implant can carry mechanical loads
Issued US, Filed CA