Seminar - Pain neurons control cancer immunosurveillance


McIntyre Medical Building Room 1034, 3655 promenade Sir William Osler, Montreal, QC, H3G 1Y6, CA

Under the mentorship of Dr Rejean Couture, Dr Talbot obtained is PhD in Physiology from the Université de Montreal (2012). His thesis focused on the role of CNS immune cells in priming diabetic pain neuropathy. Next, he joined Dr. Clifford Woolf’s lab at the Neurobiology center of Harvard Medical School to study the crosstalk between pain neurons and adaptive immune cells in the context of allergic inflammation. Since 2017, Dr Talbot joined the UdeM pharmacology and physiology dept. to start is independent work. His group combines techniques of molecular and cell biology, optogenetics, tissue clearance and imaging, electrophysiology, neuroanatomy, behavior, and genetics. They aim at defining a framework of the neuro-immune interplay at the system level, to decipher how and which sub-population of sensory neurons controls innate and adaptive responses, and to develop new targeted therapies for resolution of chronic inflammatory diseases. His work is supported by a CFI, CRC-2, CIHR, NSERC and Brain Canada. Specifically, our investigation focus on the role of nociceptor neurons in the control of cancer immunosurveillance. Our hope is that by blocking tumor innervating neurons, we will safeguard the host immune system anti-tumor immunity.