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moshe szyf

Chronic pain alters DNA marking in the brain

Pioneering study reveals association of chronic pain and broad epigenetic changes.
Thu, 2013-02-14 10:25
Injuries that result in chronic pain, such as limb injuries, and those unrelated to the brain are associated with epigenetic changes in the brain which persist months after the injury, according to researchers at McGill University. Epigenetics explores how the environment – including diet, exposure to contaminants and social conditions such as poverty – can have a long-term impact on the activity of our genes.

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Contact: Cynthia Lee
Organization: Media Relations, McGill University
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Office Phone: 514-398-6754
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Source Site: /newsroom

Early life adversity affects broad regions of brain DNA

Study provides strong evidence of a biological process that embeds social experience in DNA that affects not just a few genes but entire networks of genes.
Wed, 2012-10-10 12:41

Early life experience results in a broad change in the way our DNA is “epigenetically” chemically marked in the brain by a coat of small chemicals called methyl groups, according to researchers at McGill University. A group of researchers led by Prof. Moshe Szyf, a professor of Pharmacology and Therapeutics in the Faculty of Medicine, and research scientists at the Douglas Institute have discovered a remarkable similarity in the way the DNA in human brains and the DNA in animal brains respond to early life adversity. The finding suggests an evolutionary conserved mechanism of response to early life adversity affecting a large number of genes in the genome. 

Contact Information

Contact: Cynthia Lee
Organization: Media Relations, McGill University
Email:
Office Phone: 514-398-6754
Category:
Source Site: /newsroom