CFTRc seminar


Dr. Alice Prince

John M. and Yvonne T. Driscoll Professor of Pediatrics ; Chief, Division of Pediatric Infectious Diseases ; Columbia University ; New York


Talk title: ‘’Metabolic susceptibility to infection’’


Abstract: Exactly what defines host susceptibility to specific bacteria is not well understood. In response to infection, CF immune cells release abundant amounts of succinate and itaconate, metabolites that are substrates for Pseudomonas aeruginosa proliferation and stimulate the oxidant stress that promotes biofilm formation. The availability of a preferred carbon source helps to explain why P. aeruginosa, as opposed to many other opportunists, predominate in CF.

Supported by:


McGill University is situated on the traditional territory of the Kanien’kehà:ka, a place which has long served as a site of meeting and exchange amongst nations. We recognize and respect the Kanien’kehà:ka as the traditional custodians of these lands and waters.



Back to top