Yu (Brandon) Xia

Associate Professor
Graduate Program Director (Biological and Biomedical Engineering)
Canada Research Chair in Computational and Systems Biology

Ph.D. Stanford University
B.S. Peking University

McConnell Engineering Building, Room 360

514.398.5026
brandon.xia [at] mcgill.ca (e-mail)
website


Research Interests

  • Construction of genome-scale computer models of biomolecular networks with high spatial and temporal resolutions.
  • Use of genome-scale models to probe the biophysical and engineering principles of biological networks.
  • Use of genome-scale models to study the systems biology of diseases
  • Computational Structural Biology. Prediction and analysis of protein structure and function; evolutionary and design principles of proteins
  • Computational Systems Biology. Prediction and analysis of protein networks; evolutionary and design principles of protein networks.
  • Bioinformatics. Development and application of bioinformatics algorithms to analyze biological sequence, structural and functional data.

Courses

  • BIEN 310 Introduction to Biomolecular Engineering (3 credits)
  • BIEN 410 Computational Methods in Biomolecular Engineering (3 Credits)

Selected Publications

Structural principles within the human-virus protein-protein interaction network.
Franzosa EA, Xia Y. 
Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).

Structural determinants of protein evolution are context-sensitive at the residue level.
Franzosa EA, Xia Y. 
Mol. Biol. Evol. 26: 2387-2395 (2009).

Relating three-dimensional structures to protein networks provides evolutionary insights. 
Kim PM, Lu LJ, Xia Y, Gerstein MB. 
Science 314: 1938-1941 (2006).

Visit MEDLINE indexed publications and the following list for more.