Associate Professor
Graduate Program Director (Biological and Biomedical Engineering)
Canada Research Chair in Computational and Systems Biology
Ph.D. Stanford University
B.S. Peking University
McConnell Engineering Building, Room 360
514.398.5026
brandon.xia [at] mcgill.ca (e-mail)
website
Research Interests
- Construction of genome-scale computer models of biomolecular networks with high spatial and temporal resolutions.
- Use of genome-scale models to probe the biophysical and engineering principles of biological networks.
- Use of genome-scale models to study the systems biology of diseases
- Computational Structural Biology. Prediction and analysis of protein structure and function; evolutionary and design principles of proteins
- Computational Systems Biology. Prediction and analysis of protein networks; evolutionary and design principles of protein networks.
- Bioinformatics. Development and application of bioinformatics algorithms to analyze biological sequence, structural and functional data.
Courses
- BIEN 310 Introduction to Biomolecular Engineering (3 credits)
- BIEN 410 Computational Methods in Biomolecular Engineering (3 Credits)
Selected Publications
Structural principles within the human-virus protein-protein interaction network.
Franzosa EA, Xia Y.
Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).
Structural determinants of protein evolution are context-sensitive at the residue level.
Franzosa EA, Xia Y.
Mol. Biol. Evol. 26: 2387-2395 (2009).
Relating three-dimensional structures to protein networks provides evolutionary insights.
Kim PM, Lu LJ, Xia Y, Gerstein MB.
Science 314: 1938-1941 (2006).
Visit MEDLINE indexed publications and the following list for more.