Mario A. Jardon
Faculty Lecturer
Ph.D. University of British Columbia, Canada
M.Sc. Université Laval, Canada
B.Sc.A. Université Laval, Canada
- Implementation of Process Analytical Technology (PAT) and Quality by Design (QbD) approaches to the manufacturing of therapeutic biologics (nucleic acid and protein-based products, vaccines, gene and cell therapies)
- Bioprocess integration, acceleration, intensification and technology transfer
- High cell concentration bioprocesses, continuous bioprocessing
- Technology and strategy development for epidemic prevention and preparedness
- Application of Statistics and Data Science techniques to accelerating process development, Design Space characterization and Control Space determination for the manufacturing of biologics
- Engineering and modeling cell metabolism and cellular stress responses to increase bioprocess performance
Inhibition of glutamine-dependent autophagy increases t-PA production in CHO cell fed-batch processes. Jardon MA, Sattha B, Braasch K, Leung AO, Côté HCF, Butler M, Gorski SM, Piret JM. 2012. Biotechnology and Bioengineering, 109(5): 1228-1238.
Raman spectroscopy of live cells under autophagy-inducing conditions. Konorov SO*, Jardon MA*, Piret JM, Blades MW, Turner RFB. 2012. Analyst, 137: 4662-4668. *Equal contributions.
Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production. Kim DY, Chaudhry MA, Kennard ML, Jardon MA, Braasch K, Dionne B, Butler M, Piret JM. 2013. Biotechnol Progress, 29(1): 165-175.
Autophagy: from structure to metabolism to therapeutic regulation. Jardon MA, Rothe K, Bortnik S, Vezenkov L, Jiang X, Young RN, Lum JJ, Gorski SM. 2013. Autophagy, 9(12).
pH, pCO2, and temperature effect on R-adenovirus production. Jardon M, Garnier A. 2003. Biotechnology Progress, 19(1): 202-208.