Title: “Mechanotransduction through integrins: basic mechanisms and roles in vascular disease”
Martin Schwartz, PhD
Professor of Medicine (Cardiology)
Professor of Biomedical Engineering and of Cell Biology
Hosted by: Dr. Dieter Reinhardt
Wednesday, Oct 7, 2020 at 11:30 am
Meeting ID: 954 2425 5919
Cells sense the biochemical and biophysical properties of their extracellular matrix environment through integrin-mediated adhesions. The resultant signals play major roles in guiding development, physiology, and normal tissue remodeling required for homeostasis. Conversely, altered integrin-dependent signals contribute to pathological tissue remodeling in cancer, fibrosis, atherosclerosis, and aneurysms. I will present our recent work toward understanding fundamental, biophysical mechanisms of force transmission and mechanotransduction through integrins, and the roles of matrix remodeling and integrin signaling in vascular disease.