Systems and Behavioural Neuroscience Laboratory


Carriot J, Jamali M, Cullen KE, Chacron MJ.
Envelope statistics of self-motion signals experienced by human subjects during everyday activities: Implications for vestibular processing.
PLoS One. 2017 Jun 2;12(6):e0178664. doi: 10.1371/journal.pone.0178664. eCollection 2017.

Mitchell DE, Della Santina CC, Cullen KE.
Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance.
Sci Rep. 2017 Apr 12;7(1):853. doi: 10.1038/s41598-017-00956-5.

Carriot J, Jamali M, Chacron MJ, Cullen KE.
The statistics of the vestibular input experienced during natural self-motion differ between rodents and primates.
J Physiol. 2017 Apr 15;595(8):2751-2766. doi: 10.1113/JP273734. Epub 2017 Feb 22.

Jamali M, Chacron MJ, Cullen KE.
Self-motion evokes precise spike timing in the primate vestibular system.
Nat Commun. 2016 Oct 27;7:13229. doi: 10.1038/ncomms13229.

Cullen KE.
Physiology of central pathways.
Handb Clin Neurol. 2016;137:17-40. doi: 10.1016/B978-0-444-63437-5.00002-9. Review.

Jayabal S, Chang HH, Cullen KE, Watt AJ.
4-aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6.
Sci Rep. 2016 Jul 6;6:29489. doi: 10.1038/srep29489.

Mitchell DE, Della Santina CC, Cullen KE.
Plasticity within non-cerebellar pathways rapidly shapes motor performance in vivo.
Nat Commun. 2016 May 9;7:11238. doi: 10.1038/ncomms11238.

Straka H, Zwergal A, Cullen KE.
Vestibular animal models: contributions to understanding physiology and disease.
J Neurol. 2016 Apr;263 Suppl 1:S10-23. doi: 10.1007/s00415-015-7909-y. Epub 2016 Apr 15. Review.

Brooks JX, Carriot J, Cullen KE.
Learning to expect the unexpected: rapid updating in primate cerebellum during voluntary self-motion.
Nat Neurosci. 2015 Sep;18(9):1310-7. 

Carriot J, Jamali M, Cullen KE.
Rapid adaptation of multisensory integration in vestibular pathways.
Front Syst Neurosci. 2015 Apr 16;9:59.

Schneider AD, Jamali M, Carriot J, Chacron MJ, Cullen KE.
The increased sensitivity of irregular peripheral canal and otolith vestibular afferents optimizes their encoding of natural stimuli.
J Neurosci. 2015 Apr 8;35(14):5522-36. 

Metzen MG, Jamali M, Carriot J, Ávila-Ǻkerberg O, Cullen KE, Chacron MJ.
Coding of envelopes by correlated but not single-neuron activity requires neural variability.
Proc Natl Acad Sci U S A. 2015 Mar 30.

Sun DQ, Lehar M, Dai C, Swarthout L, Lauer AM, Carey JP, Mitchell DE, Cullen KE, Santina CC.
Histopathologic Changes of the Inner ear in Rhesus Monkeys After Intratympanic Gentamicin Injection and Vestibular Prosthesis Electrode Array Implantation.
J Assoc Res Otolaryngol. 2015 Mar 20.

Dale A, Cullen KE.
Local Population Synchrony and the Encoding of Eye Position in the Primate Neural Integrator.
J Neurosci. 2015 Mar 11;35(10):4287-95.

Carriot J, Jamali M, Brooks JX, Cullen KE.
Integration of Canal and Otolith Inputs by Central Vestibular Neurons Is Subadditive for Both Active and Passive Self-Motion: Implication for Perception.
J Neurosci. 2015 Feb 25;35(8):3555-65.

Cullen KE.
Neural circuits that drive binocular eye movements: implications for understanding and correcting strabismus.
Invest Ophthalmol Vis Sci. 2015 Jan 2;56(1):20. 

Baumann O, Borra RJ, Bower JM, Cullen KE, Habas C, Ivry RB, Leggio M, Mattingley JB, Molinari M, Moulton EA, Paulin MG, Pavlova MA, Schmahmann JD, Sokolov AA.
Consensus Paper: The Role of the Cerebellum in Perceptual Processes.
Cerebellum. 2014 Dec 6. 

Mijovic T, Carriot J, Zeitouni A, Cullen KE.
Head movements in patients with vestibular lesion: a novel approach to functional assessment in daily life setting.
Otol Neurotol. 2014 Dec;35(10):e348-57. 

Cullen KE, Brooks JX.
Neural Correlates of Sensory Prediction Errors in Monkeys: Evidence for Internal Models of Voluntary Self-Motion in the Cerebellum.
Cerebellum. 2014 Oct 8.

Luebke AE, Holt JC, Jordan PM, Wong YS, Caldwell JS, Cullen KE.
Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces the Efficacy of the Vestibulo-ocular Reflex (VOR).
J Neurosci. 2014 Jul 30;34(31):10453-8.

Carriot J, Jamali M, Chacron MJ, Cullen KE.
Statistics of the vestibular input experienced during natural self-motion: implications for neural processing.
J Neurosci. 2014 Jun 11;34(24):8347-57.

Oman CM, Cullen KE. 
Brainstem processing of vestibular sensory exafference: implications for motion sickness etiology.
Exp Brain Res. 2014 Aug;232(8):2483-92.

Brooks JX, Cullen KE.
Early vestibular processing does not discriminate active from passive self-motion if there is a discrepancy between predicted and actual proprioceptive feedback.
J Neurophysiol. 2014 Jun 15;111(12):2465-78.

Cullen KE, Brooks JX.
Consulting the vestibular system is simply a must if you want to optimize gaze shifts.
Brain. 2014 Apr;137(Pt 4):978-80.

Jamali M, Mitchell DE, Dale ACarriot JSadeghi SG, Cullen KE   
Neuronal detection thresholds during vestibular compensation: contributions of response variability and sensory substitution.
J Physiol. 2014 Feb 3.

Kathleen E. Cullen 
The neural encoding of self-generated and externally applied movement: implications for the perception of self-motion and spatial memory.
Front Integr Neurosci. 2013; 7: 108. Published on 13 January 2014.

Jerome Carriot, Jessica X. Brooks, Kathleen E. Cullen 
Multimodal Integration of Self-Motion Cues in the Vestibular System: Active versus Passive Translations.
J Neurosci. 2013 Dec 11;33(50):19555-66.

Diana E. Mitchell, Chenkai Dai, Mehdi A. Rahman, Joong Ho Ahn, Charles C. Della Santina, Kathleen E. Cullen
Head movements evoked in alert rhesus monkey by vestibular prosthesis stimulation: implications for postural and gaze stabilization.
PLoS One. 2013 Oct 17;8(10):e78767.

Ioana Medrea, Kathleen E. Cullen
Multisensory integration in early vestibular processing in mice: the encoding of passive vs. active motion.
J Neurophysiol. 2013 Dec;110(12):2704-17.

Marion R. Van Horn, David M. Waitzman, Kathleen E. Cullen 
Vergence Neurons Identified in the Rostral Superior Colliculus Code Smooth Eye Movements in 3D Space.
The Journal of Neuroscience, 24 April 2013, 33(17): 7274-7284;

Brooks JX, Cullen KE
The primate cerebellum selectively encodes unexpected self-motion.
Curr Biol. 2013 Jun 3;23(11):947-55.

Jamali M, Carriot J, Chacron MJ, Cullen KE
Strong Correlations between Sensitivity and Variability Give Rise to Constant Discrimination Thresholds across the Otolith Afferent Population.J Neurosci. 2013 Jul 3;33(27):11302-13

Dale A, Cullen KE
The nucleus prepositus predominantly outputs eye movement-related information during passive
and active self-motion. J Neurophysiol. 2013 Apr;109(7):1900-11

Sadeghi SG, Minor LB, Cullen KE.
Neural Correlates of Sensory Substitution in Vestibular Pathways following Complete Vestibular Loss.
J Neurosci. 2012 Oct 17;32(42):14685-95.

Massot C, Schneider AD, Chacron MJ, Cullen KE.
The vestibular system implements a linear-nonlinear transformation in order to encode self-motion.
PLoS Biol. 2012 Jul;10(7):e1001365.

Van Horn MR, Cullen KE.
Coding of microsaccades in three-dimensional space by premotor saccadic neurons.
J Neurosci. 2012 Feb 8;32(6):1974-80.

Cullen KE.
The vestibular system: multimodal integration and encoding of self-motion for motor control.
Trends Neurosci. 2012 Mar;35(3):185-96

Schneider AD, Cullen KE, Chacron MJ.
In vivo conditions induce faithful encoding of stimuli by reducing nonlinear synchronization in vestibular sensory neurons.
PLoS Comput Biol. 2011 Jul;7(7):e1002120.

Cullen KE.
The neural encoding of self-motion.
Curr Opin Neurobiol. 2011 Aug;21(4):587-95.

Cullen KE, Van Horn MR.
The neural control of fast vs. slow vergence eye movements.
Eur J Neurosci. 2011 Jun;33(11):2147-54.

Cullen KE, Yates BJ.
Vestibular neurophysiology: a collection of papers in honor of the career of Jay Goldberg.
Exp Brain Res. 2011 May;210(3-4):327-9.

Goldberg JM, Cullen KE.
Vestibular control of the head: possible functions of the vestibulocollic reflex.
Exp Brain Res. 2011 May;210(3-4):331-45. 

Dai C, Fridman GY, Chiang B, Davidovics NS, Melvin TA, Cullen KE, Della Santina CC.
Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesis.
Exp Brain Res. 2011 May;210(3-4):595-606.

Massot C, Chacron MJ, Cullen KE.
Information Transmission and Detection Thresholds in the Vestibular Nuclei: Single Neurons versus Population Encoding. J Neurophysiol.
2011 Feb 9

Cullen KE, Brooks JX, Jamali M, Carriot J, Massot C.
Internal models of self-motion: computations that suppress vestibular reafference in early vestibular processing. Exp Brain Res.
2011 Feb 1

Sadeghi SG, Minor LB, Cullen KE.
Multimodal integration after unilateral labyrinthine lesion: single vestibular nuclei neuron responses and implications for postural compensation.
J Neurophysiol.
2011 Feb;105(2):661-73.

Van Horn MR, Mitchell DE, Massot C, Cullen KE.
Local neural processing and the generation of dynamic motor commands within the saccadic premotor network. J Neurosci.
2010 Aug 11;30(32):10905-17.

Sadeghi SG, Minor LB, Cullen KE.
Neural correlates of motor learning in the vestibulo-ocular reflex: dynamic regulation of multimodal integration in the macaque vestibular system. J Neurosci.
2010 Jul 28;30(30):10158-68.

Sadeghi SG, Goldberg JM, Minor LB, Cullen KE
Effects of canal plugging on the vestibuloocular reflex and vestibular nerve discharge during passive and active head rotations. J Neurophysiol.
2009 Nov;102(5):2693-703.

Brooks JX, Cullen KE.
Multimodal Integration in Rostral Fastigial Nucleus Provides an Estimate of Body Movement. J Neurosci.
2009 Aug 26.

Cullen KE, Brooks JX, Sadeghi,SG.
How actions alter sensory processing: reafference in the vestibular system. Ann N Y Acad Sci.
2009 May;1164:29-36.

Van Horn MR, Cullen KE.
Dynamic characterization of agonist and antagonist oculomotoneurons during conjugate and disconjugate eye movements. J Neurophysiol.
2009 Apr 29.

Sadeghi SG, Mitchell DE, Cullen KE.
Different neural strategies for multimodal integration: comparison of two macaque monkey species. Exp Brain Res.
2009 May;195(1):45-57.

Sadeghi SG, Goldberg JM, Minor LB, Cullen KE.
Efferent-mediated responses in vestibular nerve afferents of the alert macaque. J Neurophysiol.
2009 Feb;101(2):988-1001.

Jamali M, Sadeghi SG, Cullen KE
Response of vestibular nerve afferents innervating utricle and saccule during passive and active translations. J Neurophysiol.
2009 Jan;101(1):141-9.

Waitzman DM, Van Horn MR, Cullen KE.
Neuronal evidence for individual eye control in the primate cMRF. Prog Brain Res.

Van Horn MR, Cullen KE.
Dynamic coding of vertical facilitated vergence by premotor saccadic burst neurons. J Neurophysiol.
2008 Oct;100(4):1967-82.

Cherif S, Cullen KE, Galiana HL
An improved method for the estimation of firing rate dynamics using an optimal digital filter. J Neurosci Methods
2008 Aug 15;173(1):165-81.

Beraneck M, McKee JL, Aleisa M, Cullen KE
Asymmetric recovery in cerebellar-deficient mice following unilateral labyrinthectomy. J Neurophysiol.
2008 Aug;100(2):945-58.

Angelaki DE, Cullen KE.
Vestibular system: the many facets of a multimodal sense. Annu Rev Neurosci.

Van Horn MR, Sylvestre PA, Cullen KE.
The brain stem saccadic burst generator encodes gaze in three-dimensional space. J Neurophysiol.
2008 May;99(5):2602-16.

Aleisa M, Zeitouni AG, Cullen KE.
Vestibular compensation after unilateral labyrinthectomy: normal versus cerebellar dysfunctional mice. J Otolaryngol
2007 Dec;36(6):315-21.

Beraneck M, Cullen KE.
Activity of vestibular nuclei neurons during vestibular and optokinetic stimulation in the alert mouse. J Neurophysiol.
2007 Sep;98(3):1549-65.

Sadeghi SG, Chacron MJ, Taylor MC, Cullen KE
Neural variability, detection thresholds, and information transmission in the vestibular system. J Neurosci.
2007 Jan 24;27(4):771-81.

McCluskey MK, Cullen KE.
Eye, Head, and Body Coordination during Large Gaze Shifts in Rhesus Monkeys: Movement Kinematics and the Influence of Posture. J Neurophysiol.
2007 Jan 17.

Sadeghi SG, Minor LB, Cullen KE.
Response of vestibular-nerve afferents to active and passive rotations under normal conditions and after unilateral labyrinthectomy. J Neurophysiol.
2007 Feb;97(2):1503-14.

Sadeghi SG, Minor LB, Cullen KE.
Dynamics of the horizontal vestibuloocular reflex after unilateral labyrinthectomy: response to high frequency, high acceleration, and high velocity rotations. Exp Brain Res.
2006 Nov;175(3):471-84

Pierre A. Sylvestre and Kathleen E. Cullen
Premotor Correlates of Integrated Feedback Control for Eye–Head Gaze Shifts. J. Neurosci.
May 2006; 26: 4922-4929

Pathmanathan JS, Presnell R, Cromer JA, Cullen KE, Waitzman DM.
Spatial characteristics of neurons in the central mesencephalic reticular formation (cMRF) of head-unrestrained monkeys. Exp Brain Res.
2006 Nov 15;:1-16

Pathmanathan JS, Cromer JA, Cullen KE, Waitzman DM.
Temporal characteristics of neurons in the central mesencephalic reticular formation of head unrestrained monkeys. Exp Brain Res.
2006 Nov 15;:1-22

Cullen KE.
Sensory signals during active versus passive movement. Curr Opin Neurobiol.
2004 Dec;14(6):698-706.

Cullen K.E., Huterer M., Braidwood D.A., and Sylvestre P.A.
Time course of vestibulo-ocular reflex suppression during gaze shifts. J. Neurophysiol.
92(6):3408-22, 2004.

Vidal P-P., Degallaix L., Josset P., Gasc J.P., Cullen K. E
Postural and locomotor control in normal and vestibularly deficient mice. J Physiol.
Sep 1;559(Pt2):625-38, 2004.

McClung J. R., Cullen K. E., Shall M. S., Dimitrova D. M., and Goldberg S. J.
Effects of Electrode Penetrations Into the Abducens Nucleus of the Monkey: Eye Movement Recordings and Histopathological Evaluation of the Nuclei and Lateral Rectus Muscles. Exp Brain Res.
158(2):180-8, 2004.

Cullen K.E and Roy J. E.
Signal Processing in the Vestibular System during Active versus Passive Head Movements. J. Neurophysiol.
91(5):1919-33, 2004.

Roy J. E. and Cullen K.E.
Dissociating Self-Generated from Passively Applied Head Motion: Neural Mechanisms in the Vestibular Nuclei. J. Neuroscience, 24(9):2102-11

Roy J. E. and Cullen K.E.
Brain stem pursuit pathways: dissociating visual, vestibular, and proprioceptive inputs during combined eye-head gaze tracking. J. Neurophysiol, 90:271-90,

Sylvestre P.A., Choi J.T.L., and Cullen K.E
Discharge Dynamics of Oculomotor Neural Integrator Neurons During Conjugate and Disjunctive Saccades and Fixation, J. Neurophysiol , 90:739-54

Sylvestre P.A. and Cullen K.E.
Dynamics of abducens nucleus neuron discharges during disjunctive saccades. J. Neurophysiol, 88:3452-68,

Huterer M. and Cullen K.E.
Vestibuloocular Reflex Dynamics during High Frequency and High Acceleration Rotations of the Head-on-Body in Rhesus Monkey. J. Neurophysiol, 88:13-28

Cullen K.E. and Minor L.B.
Semicircular Canal Afferents Similarly Encode Active and Passive Head-on-Body Rotations: Implications for the Role of Vestibular Efference. J. Neuroscience, 22(RC226):1-7

Roy J.E. and Cullen K.E.
Modulation of Vestibulo-Ocular Reflex Signals during Voluntary versus Passive Head Movements. J. Neurophysiol, 87(5):2337-57

Dubrovsky A.S. and Cullen K.E.
Gaze-, Eye-, and Head-Movement Dynamics During Closed- and Open-Loop Gaze Pursuit. J. Neurophysiol, 87(2):859-75,

Sylvestre P.A., Galiana H.I. and Cullen K.E.
Conjugate and vergence oscillations during saccades and gaze shifts: implications for integrated control of binocular movement. J. Neurophysiol, 87(1):257-72

Sylvestre P.A., Roy J.E. and Cullen K.E.
Do Extraocular Motoneurons Encode Head Velocity During Head-Restrained versus Head-Unrestrained Saccadic and Smooth Pursuit Movements? New York Academy of Sciences, 942:497-500

Roy J.E. and Cullen K.E.
Passive Activation of Neck Proprioceptive Inputs Does Not Influence the Discharge Patterns of Vestibular Nuclei Neurons. New York Academy of Sciences, 942:486-9,

Cullen K.E., Roy J.E. and Sylvestre P.A.
Signal Processing in the Vestibular Nuclei is Dependent on the Current Behavioral Goal. New York Academy of Sciences 942:345-63,

Roy J.E. and Cullen K.E
Selective Processing of Vestibular Reafference during Self-Generated Motion. J. Neuroscience, 21:2131-2142,

Wellenius G.A. and Cullen K.E
A Comparison of Head-Unrestrained versus Head-Restrained Pursuit: Influence of Eye Position and Target Velocity on Latency. Exp. Brain Res, 133:139-155,

Cullen K.E., Galiana H.I. and Sylvestre P.A.
Comparing Extraocular Motoneuron Discharges during Head-Restrained Saccades and Head-Unrestrained Gaze Shifts. J. Neurophysiol, 83:630-637,

Cullen K.E.,Rey C.G., Guitton D. and Galiana H.L.  
The Use of System Identification Techniques in the Analysis of Oculomotor Burst Neuron Spike Train Dynamics. Journal of Computational Neuroscience 3, 347-368 (1996)    


Book Chapters

Sylvestre P.A. and Cullen K.E. 
The Encyclopedia of Neuroscience, “Gaze, Control and Plasticity”, Eds. George Adelman and Barry H. Smith, 2003.

Cullen K.E., Roy J.E. and Sylvestre P.A. 
Signal Processing in Vestibular Nuclei: Dissociating Sensory, Motor and Cognitive Influences. In: Levels of Perception, L. Harris and M. Jenkin (eds.) Oxford Univ. Press, (in press) 

Cullen K.E., Rey C.G. and Guitton D. 
Dynamic Models of Primate and Cat Burst Neuron Activity during Head-fixed Saccades and Head-free Gaze Shifts. Contemporary Ocular Motor and Vestibular Research: A Tribute to David A. Robinson. U. Buttner, A.F. Fuchs, T.H. Brandt, and D.S. Zee (eds.) Thieme Verlag Stuttgart Press, 1994. 

McCrea R.A. and Cullen K.E. 
A Mechanism for Voluntary Cancellation of the Vestibulo-Ocular Reflex in Squirrel Monkeys Not Related to Smooth Pursuit. In: The Head-Neck Sensory Motor System. A. Bertoz, P.P. Vidal, W. Graf (eds.) Oxford University Press, 1991.