Associate Professor, Departments of Neurology & Neurosurgery and Medicine, McGill University
Montreal Neurological Institute
3801 University Street
Montreal, Quebec H3A 2B4
josephine.nalbantoglu [at] mcgill.ca (Email)
Dr. Nalbantoglu's Web Page
Expertise: Adenovirus-mediated gene therapy of experimental gliomas and medullablastomas using tumour suppressor and "suicide" genes
Summary of Research Activities
There are three broad areas of research in the lab – gene therapy of brain tumours, gene therapy of muscle diseases and functional studies on CAR (coxsackie and adenovirus receptor).
We use adenovirus and adeno-associated virus vectors for suicide gene therapy and anti-angiogenic therapy in xenograft models of brain tumours. We are optimizing vascular delivery of viral vectors to disseminated tumours as well as developing gene transfer methods to target cancer stem cells.
The study of the physiological function of CAR is a major focus of the laboratory. We have shown CAR to be a suppressor of tumour growth and invasion for gliomas. We are identifying the proteins and pathways which mediate this effect of CAR. As the highest expression of CAR is in the developing nervous system, we are using a variety of approaches to study the role of CAR neuronal function (primary cultures, conditional knockouts, behavioral analysis).
Deol JR, Danialou G, Larochelle N, Bourget M, Moon JS, Liu AB, Gilbert R, Petrof BJ, Nalbantoglu J, Karpati G. Successful Compensation for Dystrophin Deficiency by a Helper-dependent Adenovirus Expressing Full-length Utrophin. Mol Ther. 2007 Oct;15(10):1767-74. Epub 2007 Jul 31.
Huang KC, Yasruel Z, Guerin C, Holland PC, Nalbantoglu J. Interaction of the Coxsackie and adenovirus receptor (CAR) with the cytoskeleton: binding to actin. FEBS Lett. 2007 Jun 12;581(14):2702-8. Epub 2007 May 21.
Kimmelman J, Nalbantoglu J. Faithful companions: a proposal for neurooncology trials in pet dogs. Cancer Res. 2007 May 15;67(10):4541-4.
Durocher Y, Pham PL, St-Laurent G, Jacob D, Cass B, Chahal P, Lau CJ, Nalbantoglu J, Kamen A. Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells. J Virol Methods. 2007 Apr 27; [Epub ahead of print]
Bourbeau D, Lau CJ, Jaime J, Koty Z, Zehntner SP, Lavoie G, Mes-Masson AM, Nalbantoglu J, Massie B. Improvement of antitumor activity by gene amplification with a replicating but nondisseminating adenovirus. Cancer Res. 2007 Apr 1;67(7):3387-95.
Fok PT, Huang KC, Holland PC, Nalbantoglu J. The Coxsackie and adenovirus receptor binds microtubules and plays a role in cell migration. J Biol Chem. 2007 Mar 9;282(10):7512-21. Epub 2007 Jan 7.
Shaw CA, Larochelle N, Dudley RW, Lochmuller H, Danialou G, Petrof BJ, Karpati G, Holland PC, Nalbantoglu J. Simultaneous dystrophin and dysferlin deficiencies associated with high-level expression of the coxsackie and adenovirus receptor in transgenic mice. Am J Pathol. 2006 Dec;169(6):2148-60.
Batulan Z, Taylor DM, Aarons RJ, Minotti S, Doroudchi MM, Nalbantoglu J, Durham HD. Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis. Neurobiol Dis. 2006 Nov;24(2):213-25. Epub 2006 Sep 6.
Hollmann CA, Owens T, Nalbantoglu J, Hudson TJ, Sladek R. Constitutive activation of extracellular signal-regulated kinase predisposes diffuse large B-cell lymphoma cell lines to CD40-mediated cell death. Cancer Res. 2006 Apr 1;66(7):3550-7.