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William Lubell

William Lubell

Professor, Department of Chemistry, Université de Montréal

Address
Department of Chemistry
Université de Montréal
P.O.Box 6128, Station Centre-Ville
Montreal, Quebec H3C 3J7

Tel.: 514-343-6111 ext. 7339
Fax: 514-343-7586
lubell [at] chimie [dot] umontreal [dot] ca (Email)

Expertise: Peptide Mimicry; Combinatorial chemistry; Biologically Active Peptides; Amino Acids; Ligands for Neuroscience; Solid-Phase Chemistry

Summary of research activities
I have been actively investigating solution-phase and solid-phase synthesis of heterocycles, amino acids, peptides, peptide mimics and the preparation of their libraries by combinatorial science. My interests lie both in developing new methodology for effectively synthesizing these novel structures for drug discovery, as well as in their use to explore protein folding, molecular recognition and bioorganic catalysis.

Recent Publications
Iden HS, Lubell WD . 1,3,5-Trisubstituted 1,4-Diazepin-2-ones. J Org Chem. 2007 Oct 10; [Epub ahead of print]

Luo J, Pardin C, Zhu XX, Lubell WD . Preparation, characterization, and application of poly(vinyl alcohol)-graft-poly(ethylene glycol) resins: novel polymer matrices for solid-phase synthesis. J Comb Chem. 2007 Jul-Aug;9(4):582-91. Epub 2007 Jun 23.

Luo J, Pardin C, Lubell WD . Zhu XX. Poly(vinyl alcohol)-graft-poly(ethylene glycol) resins and their use in solid-phase synthesis and supported TEMPO catalysis. Chem Commun (Camb). 2007 Jun 7;(21):2136-8. Epub 2007 Feb 2

Boeglin D, Hamdan FF, Melendez RE, Cluzeau J, Laperriere A, Heroux M, Bouvier M, Lubell WD . Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor. J Med Chem. 2007 Mar 22;50(6):1401-8. Epub 2007 Feb 24.

Rao MH, Pinyol E, Lubell WD . Rigid dipeptide mimics: synthesis of enantiopure C6-functionalized pyrrolizidinone amino acids. J Org Chem. 2007 Feb 2; 72(3):736-43.

Dorr A, Lubell WD . Synthesis of a new pi-defficient phenylalanine derivative from a common 1,4-Diketone Intermediate and study of the influence of aromatic density on prolyl amide isomer population. Biopolymers. 2007; 88(2):290-9.

Jolicoeur B, Lubell WD . 4-alkoxy- and 4-amino-2,2'-bipyrrole synthesis. Org Lett. 2006 Dec 21;8(26):6107-10.

Iden HS, Lubell WD . 1,4-Diazepinone and pyrrolodiazepinone syntheses via homoallylic ketones from cascade addition of vinyl Grignard reagent to alpha-aminoacyl-beta-amino esters. Org Lett. 2006 Aug 3;8(16):3425-8.

Surprenant S, Lubell WD . From macrocycle dipeptide lactams to azabicyclo [X.Y.0] alkanone amino acids: a transannular cyclization route for peptide mimic synthesis. Org Lett. 2006 Jun 22;8(13):2851-4

Surprenant S, Lubell WD .9-(4-Bromophenyl)-9-fluorenyl as a safety-catch nitrogen protecting group. J Org Chem. 2006 Jan 20;71(2):848-51.

Brouillette Y, Rombouts FJ, Lubell WD . Solid-phase synthesis of 3- aminopyrrole -2,5-dicarboxylate analogues. J Comb Chem. 2006 Jan-Feb;8(1):117-26.