Associate Professor, Department of Pathology and Cell Biology, Université de Montréal
Canada Research Chair in Molecular Biology of the Cell Nucleus
Université de Montréal
P.O. Box 6128, Station Centre-ville
Montreal, Quebec H3C 3J7
katherine [dot] borden [at] umontreal [dot] ca (Email)
Dr. Borden's Web Page
Expertise: Structure and Function of the Cell Nucleus
Summary of Research Activities
A key issue in cancer biology is the way in which cells become cancerous. Our research team has found that disruption of certain nuclear processes in the cell contribute to the transformation of a healthy cell into a cancerous one. One protein in particular–the eukaryotic translation initiation factor eIF4E–when deregulated, contributes to this transformation process. Using cell and molecular biological, biophysical and atomic resolution structural studies, our team aims to elucidate the molecular underpinnings of the biochemical events which lead to cells becoming cancerous.
Culjkovic B, Topisirovic I, Borden KL. Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E. Cell Cycle. 2007 Jan;6(1):65-9. Epub 2007 Jan 11.
Poyurovsky MV, Priest C, Kentsis A, Borden KL, Pan ZQ, Pavletich N, Prives C. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J. 2007 Jan 10;26(1):90-101. Epub 2006 Dec 14.
Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden KL. eIF4E is a central node of an RNA regulon that governs cellular proliferation. J Cell Biol. 2006 Nov 6;175(3):415-26. Epub 2006 Oct 30.
Volpon L, Osborne MJ, Topisirovic I, Siddiqui N, Borden KL. Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands. EMBO J. 2006 Nov 1;25(21):5138-49. Epub 2006 Oct 12.
Laine A, Topisirovic I, Zhai D, Reed JC, Borden KL, Ronai Z. Regulation of p53 localization and activity by Ubc13. Mol Cell Biol. 2006 Dec;26(23):8901-13. Epub 2006 Sep 25
Volpon L, Osborne MJ, Borden KL. NMR assignment of human eukaryotic translation initiation factor 4E (eIF4E) in its cap-free form. J Biomol NMR. 2006 Dec;36 Suppl 5:65. Epub 2006 Jul 27.
Garcia CC, Djavani M, Topisirovic I, Borden KL, Salvato MS, Damonte EB. Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds. J Gen Virol. 2006 May;87(Pt 5):1217-28